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Study · Animal study (in vivo) · rat · 2018

12 results

Parathyroid hormone-(1-34) ameliorated knee osteoarthritis in rats via autophagy.

Chen CH, Ho ML, Chang LH, Kang L, Lin YS, Lin SY, Wu SC, Chang JK

Journal of applied physiology (Bethesda, Md. : 1985)4 Jan 2018Cited by 40 (Europe PMC)

PMID29357491 (opens in a new tab)DOI10.1152/japplphysiol.00871.2017 (opens in a new tab)PepBankPUB-29357491
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ACLT-induced osteoarthritis, PTH-(1-34) improved weight bearing versus untreated osteoarthritis.

    In plain wordsIn rats with knee osteoarthritis, PTH improved weight bearing compared with untreated osteoarthritis.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseWeight bearing
    Study

    ratsn: not reported in source

    ACL transection-induced osteoarthritis
    Comparator
    Untreated ACLT-induced osteoarthritis
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articularAs given in this study (rats).

    Source sentences

    Summary
    Additionally, PTH-(1-34) treatment significantly improved weight bearing and treadmill endurance, preserved GAG and collagen type II, and reduced the OARSI score and terminal differentiation markers.
    1 context sentence
    Summary · context
    Thirty-six rats were randomized into three groups: control group, ACLT-induced OA (OA) group, and OA with intra-articular PTH-(1-34) treatment (OA+PTH) group.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ACLT-induced osteoarthritis, PTH-(1-34) improved treadmill endurance versus untreated osteoarthritis.

    In plain wordsIn rats with knee osteoarthritis, PTH improved running endurance compared with untreated osteoarthritis.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTreadmill endurance
    Study

    ratsn: not reported in source

    ACL transection-induced osteoarthritis
    Comparator
    Untreated ACLT-induced osteoarthritis
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articularAs given in this study (rats).

    Source sentences

    Summary
    Additionally, PTH-(1-34) treatment significantly improved weight bearing and treadmill endurance, preserved GAG and collagen type II, and reduced the OARSI score and terminal differentiation markers.
    1 context sentence
    Summary · context
    Thirty-six rats were randomized into three groups: control group, ACLT-induced OA (OA) group, and OA with intra-articular PTH-(1-34) treatment (OA+PTH) group.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ACLT-induced osteoarthritis, PTH-(1-34) preserved cartilage glycosaminoglycan versus untreated osteoarthritis.

    In plain wordsIn rats with knee osteoarthritis, PTH preserved cartilage glycosaminoglycan compared with untreated osteoarthritis.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCartilage glycosaminoglycan
    Study

    ratsn: not reported in source

    ACL transection-induced osteoarthritis
    Comparator
    Untreated ACLT-induced osteoarthritis
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articularAs given in this study (rats).

    Source sentences

    Summary
    Additionally, PTH-(1-34) treatment significantly improved weight bearing and treadmill endurance, preserved GAG and collagen type II, and reduced the OARSI score and terminal differentiation markers.
    1 context sentence
    Summary · context
    Thirty-six rats were randomized into three groups: control group, ACLT-induced OA (OA) group, and OA with intra-articular PTH-(1-34) treatment (OA+PTH) group.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ACLT-induced osteoarthritis, PTH-(1-34) preserved collagen type II versus untreated osteoarthritis.

    In plain wordsIn rats with knee osteoarthritis, PTH preserved cartilage collagen compared with untreated osteoarthritis.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCartilage collagen type II
    Study

    ratsn: not reported in source

    ACL transection-induced osteoarthritis
    Comparator
    Untreated ACLT-induced osteoarthritis
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articularAs given in this study (rats).

    Source sentences

    Summary
    Additionally, PTH-(1-34) treatment significantly improved weight bearing and treadmill endurance, preserved GAG and collagen type II, and reduced the OARSI score and terminal differentiation markers.
    1 context sentence
    Summary · context
    Thirty-six rats were randomized into three groups: control group, ACLT-induced OA (OA) group, and OA with intra-articular PTH-(1-34) treatment (OA+PTH) group.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ACLT-induced osteoarthritis, PTH-(1-34) reduced OARSI scores versus untreated osteoarthritis.

    In plain wordsIn rats with knee osteoarthritis, PTH reduced cartilage damage scores compared with untreated osteoarthritis.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseOARSI score
    Study

    ratsn: not reported in source

    ACL transection-induced osteoarthritis
    Comparator
    Untreated ACLT-induced osteoarthritis
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articularAs given in this study (rats).

    Source sentences

    Summary
    Additionally, PTH-(1-34) treatment significantly improved weight bearing and treadmill endurance, preserved GAG and collagen type II, and reduced the OARSI score and terminal differentiation markers.
    1 context sentence
    Summary · context
    Thirty-six rats were randomized into three groups: control group, ACLT-induced OA (OA) group, and OA with intra-articular PTH-(1-34) treatment (OA+PTH) group.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ACLT-induced osteoarthritis, PTH-(1-34) reduced the collagen type X terminal differentiation marker versus untreated osteoarthritis.

    In plain wordsIn rats with knee osteoarthritis, PTH reduced collagen type X compared with untreated osteoarthritis.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseCollagen type X terminal differentiation marker
    Study

    ratsn: not reported in source

    ACL transection-induced osteoarthritis
    Comparator
    Untreated ACLT-induced osteoarthritis
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articularAs given in this study (rats).

    Source sentences

    Summary
    Additionally, PTH-(1-34) treatment significantly improved weight bearing and treadmill endurance, preserved GAG and collagen type II, and reduced the OARSI score and terminal differentiation markers.
    2 context sentences
    Summary · context
    terminal differentiation markers (collagen type X and Indian hedgehog)
    Summary · context
    Thirty-six rats were randomized into three groups: control group, ACLT-induced OA (OA) group, and OA with intra-articular PTH-(1-34) treatment (OA+PTH) group.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ACLT-induced osteoarthritis, PTH-(1-34) reduced chondrocyte apoptosis versus untreated osteoarthritis.

    In plain wordsIn rats with knee osteoarthritis, PTH reduced cartilage cell death compared with untreated osteoarthritis.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseChondrocyte apoptosis
    Study

    ratsn: not reported in source

    ACL transection-induced osteoarthritis
    Comparator
    Untreated ACLT-induced osteoarthritis
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articularAs given in this study (rats).

    Source sentences

    Summary
    Finally, PTH-(1-34) ameliorated chondrocyte apoptosis by regulating the expression of autophagy-related proteins, through reducing mechanistic target of rapamycin (mTOR) and p62 and enhancing microtubule-associated protein-1 light chain 3 (LC3) and beclin-1.
    1 context sentence
    Summary · context
    Thirty-six rats were randomized into three groups: control group, ACLT-induced OA (OA) group, and OA with intra-articular PTH-(1-34) treatment (OA+PTH) group.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats with ACLT-induced osteoarthritis, PTH-(1-34) reduced mTOR expression versus untreated osteoarthritis.

    In plain wordsIn rats with knee osteoarthritis, PTH reduced mTOR compared with untreated osteoarthritis.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreasemTOR expression
    Study

    ratsn: not reported in source

    ACL transection-induced osteoarthritis
    Comparator
    Untreated ACLT-induced osteoarthritis
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articularAs given in this study (rats).

    Source sentences

    Summary
    Finally, PTH-(1-34) ameliorated chondrocyte apoptosis by regulating the expression of autophagy-related proteins, through reducing mechanistic target of rapamycin (mTOR) and p62 and enhancing microtubule-associated protein-1 light chain 3 (LC3) and beclin-1.
    1 context sentence
    Summary · context
    Thirty-six rats were randomized into three groups: control group, ACLT-induced OA (OA) group, and OA with intra-articular PTH-(1-34) treatment (OA+PTH) group.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats with ACLT-induced osteoarthritis, PTH-(1-34) reduced p62 expression versus untreated osteoarthritis.

    In plain wordsIn rats with knee osteoarthritis, PTH reduced p62 compared with untreated osteoarthritis.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Decreasep62 expression
    Study

    ratsn: not reported in source

    ACL transection-induced osteoarthritis
    Comparator
    Untreated ACLT-induced osteoarthritis
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articularAs given in this study (rats).

    Source sentences

    Summary
    Finally, PTH-(1-34) ameliorated chondrocyte apoptosis by regulating the expression of autophagy-related proteins, through reducing mechanistic target of rapamycin (mTOR) and p62 and enhancing microtubule-associated protein-1 light chain 3 (LC3) and beclin-1.
    1 context sentence
    Summary · context
    Thirty-six rats were randomized into three groups: control group, ACLT-induced OA (OA) group, and OA with intra-articular PTH-(1-34) treatment (OA+PTH) group.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In rats with ACLT-induced osteoarthritis, PTH-(1-34) enhanced LC3 expression versus untreated osteoarthritis.

    In plain wordsIn rats with knee osteoarthritis, PTH increased LC3 compared with untreated osteoarthritis.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseLC3 expression
    Study

    ratsn: not reported in source

    ACL transection-induced osteoarthritis
    Comparator
    Untreated ACLT-induced osteoarthritis
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articularAs given in this study (rats).

    Source sentences

    Summary
    Finally, PTH-(1-34) ameliorated chondrocyte apoptosis by regulating the expression of autophagy-related proteins, through reducing mechanistic target of rapamycin (mTOR) and p62 and enhancing microtubule-associated protein-1 light chain 3 (LC3) and beclin-1.
    1 context sentence
    Summary · context
    Thirty-six rats were randomized into three groups: control group, ACLT-induced OA (OA) group, and OA with intra-articular PTH-(1-34) treatment (OA+PTH) group.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In rats with ACLT-induced osteoarthritis, PTH-(1-34) enhanced beclin-1 expression versus untreated osteoarthritis.

    In plain wordsIn rats with knee osteoarthritis, PTH increased beclin-1 compared with untreated osteoarthritis.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBeclin-1 expression
    Study

    ratsn: not reported in source

    ACL transection-induced osteoarthritis
    Comparator
    Untreated ACLT-induced osteoarthritis
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articularAs given in this study (rats).

    Source sentences

    Summary
    Finally, PTH-(1-34) ameliorated chondrocyte apoptosis by regulating the expression of autophagy-related proteins, through reducing mechanistic target of rapamycin (mTOR) and p62 and enhancing microtubule-associated protein-1 light chain 3 (LC3) and beclin-1.
    1 context sentence
    Summary · context
    Thirty-six rats were randomized into three groups: control group, ACLT-induced OA (OA) group, and OA with intra-articular PTH-(1-34) treatment (OA+PTH) group.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ACLT-induced osteoarthritis, PTH-(1-34) reduced the Indian hedgehog terminal differentiation marker versus untreated osteoarthritis.

    In plain wordsIn rats with knee osteoarthritis, PTH reduced Indian hedgehog compared with untreated osteoarthritis.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseIndian hedgehog terminal differentiation marker
    Study

    ratsn: not reported in source

    ACL transection-induced osteoarthritis
    Comparator
    Untreated ACLT-induced osteoarthritis
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · intra-articularAs given in this study (rats).

    Source sentences

    Summary
    Additionally, PTH-(1-34) treatment significantly improved weight bearing and treadmill endurance, preserved GAG and collagen type II, and reduced the OARSI score and terminal differentiation markers.
    2 context sentences
    Summary · context
    The histological results indicated that GAG, collagen type II, and chondrocyte autophagy had decreased but that the OARSI score, terminal differentiation markers (collagen type X and Indian hedgehog), and chondrocyte apoptosis had increased in the OA group.
    Summary · context
    Thirty-six rats were randomized into three groups: control group, ACLT-induced OA (OA) group, and OA with intra-articular PTH-(1-34) treatment (OA+PTH) group.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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