Aerobic-Strength Exercise Improves Metabolism and Clinical State in Parkinson's Disease Patients.

Krumpolec P, Vallova S, Slobodova L, Tirpakova V, Vajda M, Schon M, Klepochova R, Janakova Z, Straka I, Sutovsky S, Turcani P, Cvecka J and 7 more

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Valkovic L, Tsai CL, Krssak M, Valkovic P, Sedliak M, Ukropcova B, Ukropec J

Frontiers in neurology22 Dec 2017Cited by 30 (Europe PMC)

PMID29312123PMCIDPMC5743754DOI10.3389/fneur.2017.00698PepBankPUB-29312123

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Summary

Regular exercise ameliorates motor symptoms in Parkinson's disease (PD). Here, we aimed to provide evidence that exercise brings additional benefits to the whole-body metabolism and skeletal muscle molecular and functional characteristics, which might help to explain exercise-induced improvements in the clinical state. 3-months supervised endurance/strength training was performed in early/mid-stage PD patients and age/gender-matched individuals (n = 11/11). The effects of exercise on resting energy expenditure (REE), glucose metabolism, adiposity, and muscle energy metabolism (³¹P-MRS) were evaluated and compared to non-exercising PD patients. Two muscle biopsies were taken to determine intervention-induced changes in fiber type, mitochondrial content, and expression of genes related to muscle energy metabolism, as well as proliferative and regenerative capacity. Exercise improved the clinical disability score (MDS-UPDRS), bradykinesia, balance, walking speed, REE, and glucose metabolism and increased muscle expression of energy sensors (AMPK). However, the exercise-induced increase in muscle mass/strength, mitochondrial content, type II fiber size, and postexercise phosphocreatine (PCr) recovery (³¹P-MRS) were found only in controls. Nevertheless, MDS-UPDRS was associated with muscle AMPK and mechano-growth factor (MGF) expression. Improvements in fasting glycemia were positively associated with muscle function and the expression of Sirt1 and Cox7a1, and the parameters of fitness/strength were positively associated with the expression of MyHC2, MyHC7, and MGF. Moreover, reduced bradykinesia was associated with better muscle metabolism (maximal oxidative capacity and postexercise PCr recovery; ³¹P-MRS). Exercise training improved the clinical state in early/mid-stage Parkinson's disease patients, including motor functions and whole-body metabolism. Although the adaptive response to exercise in PD was different from that of controls, exercise-induced improvements in the PD clinical state were associated with specific adaptive changes in muscle functional, metabolic, and molecular characteristics.Clinical trial registrationwww.ClinicalTrials.gov, identifier NCT02253732.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelNon-randomized trialMechanism
In patients with Parkinson's disease who did exercise training, the clinical disability score was associated with muscle expression of the body's own MGF.
In plain wordsIn people with Parkinson's disease, the disability score was linked to the body's own MGF levels in muscle.
Peptide
MGF / PEG-MGF
Outcome
Not applicableAssociation of MDS-UPDRS with muscle MGF expression
Study
n: not reported in source
Outcome group
Exercise and physical function · Musculoskeletal
Source sentences
Summary
MDS-UPDRS was associated with muscle AMPK and mechano-growth factor (MGF) expression.
1 context sentence(design, population, supporting numbers)
Summary · context
3-months supervised endurance/strength training was performed in early/mid-stage PD patients and age/gender-matched individuals (n = 11/11).
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-2931212301
02HumanEndogenous levelNon-randomized trialMechanism
In patients with Parkinson's disease who did exercise training, fitness and strength parameters were positively associated with muscle expression of the body's own MGF.
In plain wordsIn people with Parkinson's disease, better fitness and strength were linked to higher body's own MGF levels in muscle.
Peptide
MGF / PEG-MGF
Outcome
Not applicableAssociation of fitness and strength with muscle MGF expression
Study
n: not reported in source
Outcome group
Exercise and physical function · Musculoskeletal
Source sentences
Summary
the parameters of fitness/strength were positively associated with the expression of MyHC2, MyHC7, and MGF.
1 context sentence(design, population, supporting numbers)
Summary · context
3-months supervised endurance/strength training was performed in early/mid-stage PD patients and age/gender-matched individuals (n = 11/11).
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-2931212302

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

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Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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