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Study · Animal study (in vivo) · rat · 2018

2 results

Prospective, randomized, blinded, and placebo-controlled study of Cerebrolysin dose-response effects on long-term functional outcomes in a rat model of mild traumatic brain injury.

Zhang Y, Chopp M, Gang Zhang Z, Zhang Y, Zhang L, Lu M, Zhang T, Winter S, Brandstätter H, Mahmood A, Xiong Y

Journal of neurosurgery5 Jan 2018Cited by 9 (Europe PMC)

PMID29303438 (opens in a new tab)DOI10.3171/2017.6.jns171007 (opens in a new tab)PepBankPUB-29303438
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with mild closed head injury, Cerebrolysin improved long-term functional outcomes in a placebo-controlled study.

    In plain wordsIn rats with mild head injury, Cerebrolysin improved long-term function in a placebo-controlled study.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseLong-term functional outcomes
    Study

    ratn: not reported in source

    Mild closed head injury
    Comparator
    Placebo
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.8-7.5 ml/kg · 10 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    Using a prospective, randomized, blinded, placebo-controlled protocol, the authors demonstrated that Cerebrolysin at doses of 0.8-7.5 ml/kg, administered 4 hours after injury and then once daily for a total of 10 consecutive days, improves long-term functional outcomes in a rat model of mild closed…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with mild closed head injury, the study identified 2.5 ml/kg Cerebrolysin as the optimal dose.

    In plain wordsIn rats with mild head injury, the study identified 2.5 ml/kg Cerebrolysin as the optimal dose.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableOptimal functional outcome dose
    Study

    ratn: not reported in source

    Mild closed head injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · 10 consecutive daysAs given in this study (rat).

    Measurements

    Optimal dose
    2.5 ml/kg
    Cerebrolysin

    Source sentences

    Summary
    Using a prospective, randomized, blinded, placebo-controlled protocol, the authors demonstrated that Cerebrolysin at doses of 0.8-7.5 ml/kg, administered 4 hours after injury and then once daily for a total of 10 consecutive days, improves long-term functional outcomes in a rat model of mild closed…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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