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Study · Randomized controlled trial · 2018

5 results

Effects of oxytocin on cortisol reactivity and conflict resolution behaviors among couples with substance misuse.

Flanagan JC, Fischer MS, Nietert PJ, Back SE, Maria MM, Snead A, Brady KT

Psychiatry research6 Dec 2017Cited by 26 (Europe PMC)

PMID29232576 (opens in a new tab)PMCIDPMC5988859 (opens in a new tab)DOI10.1016/j.psychres.2017.12.003 (opens in a new tab)PepBankPUB-29232576
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In women in couples with substance misuse, oxytocin attenuated the cortisol response after the conflict task versus placebo.

    In plain wordsIn women in couples with substance misuse, oxytocin lowered the cortisol response after a conflict task compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseCortisol response following conflict task, women
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Endocrine and hormones
    Studied dose
    40 IUAs given in this study (human).

    Source sentences

    Summary
    Among women, oxytocin attenuated cortisol response following the task.
    2 context sentences
    Summary · context
    Participants (N = 33 couples or 66 total participants) were heterosexual couples in which one or both partners endorsed substance misuse.
    Summary · context
    Using a double-blind, placebo-controlled, repeated-measures design and an evidence-based behavioral coding system, we compared the impact of oxytocin (40 IU) vs. placebo on cortisol reactivity and conflict resolution behaviors.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women in couples with substance misuse, oxytocin was associated with increased Distress Maintaining Attributions versus placebo.

    In plain wordsIn women in couples with substance misuse, oxytocin was linked to more distress-maintaining thinking about the partner than placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseDistress Maintaining Attributions, women
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    40 IUAs given in this study (human).

    Source sentences

    Summary
    Among women, oxytocin attenuated cortisol response following the task. Oxytocin was also associated with increased Distress Maintaining Attributions and decreased Relationship Enhancing Attributions.
    2 context sentences
    Summary · context
    Participants (N = 33 couples or 66 total participants) were heterosexual couples in which one or both partners endorsed substance misuse.
    Summary · context
    Using a double-blind, placebo-controlled, repeated-measures design and an evidence-based behavioral coding system, we compared the impact of oxytocin (40 IU) vs. placebo on cortisol reactivity and conflict resolution behaviors.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In women in couples with substance misuse, oxytocin was associated with decreased Relationship Enhancing Attributions versus placebo.

    In plain wordsIn women in couples with substance misuse, oxytocin was linked to less relationship-enhancing thinking about the partner than placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseRelationship Enhancing Attributions, women
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    40 IUAs given in this study (human).

    Source sentences

    Summary
    Among women, oxytocin attenuated cortisol response following the task. Oxytocin was also associated with increased Distress Maintaining Attributions and decreased Relationship Enhancing Attributions.
    2 context sentences
    Summary · context
    Participants (N = 33 couples or 66 total participants) were heterosexual couples in which one or both partners endorsed substance misuse.
    Summary · context
    Using a double-blind, placebo-controlled, repeated-measures design and an evidence-based behavioral coding system, we compared the impact of oxytocin (40 IU) vs. placebo on cortisol reactivity and conflict resolution behaviors.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In men in couples with substance misuse, oxytocin was associated with decreased Distress Maintaining Attributions versus placebo.

    In plain wordsIn men in couples with substance misuse, oxytocin was linked to less distress-maintaining thinking about the partner than placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseDistress Maintaining Attributions, men
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    40 IUAs given in this study (human).

    Source sentences

    Summary
    Among men, oxytocin was associated with decreased Distress Maintaining Attributions
    2 context sentences
    Summary · context
    Participants (N = 33 couples or 66 total participants) were heterosexual couples in which one or both partners endorsed substance misuse.
    Summary · context
    Using a double-blind, placebo-controlled, repeated-measures design and an evidence-based behavioral coding system, we compared the impact of oxytocin (40 IU) vs. placebo on cortisol reactivity and conflict resolution behaviors.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In men in couples with substance misuse, Relationship Enhancing Attributions declined with both oxytocin and placebo, so the decline is not specific to oxytocin.

    In plain wordsIn men in couples with substance misuse, relationship-enhancing thinking fell with both oxytocin and placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeRelationship Enhancing Attributions, men
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    40 IUAs given in this study (human).

    Source sentences

    Summary
    both oxytocin and placebo yielded declines in Relationship Enhancing Attributions
    2 context sentences
    Summary · context
    Participants (N = 33 couples or 66 total participants) were heterosexual couples in which one or both partners endorsed substance misuse.
    Summary · context
    Using a double-blind, placebo-controlled, repeated-measures design and an evidence-based behavioral coding system, we compared the impact of oxytocin (40 IU) vs. placebo on cortisol reactivity and conflict resolution behaviors.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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