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Study · Animal study (in vivo) · mouse · 2017

4 results

Transdermal Delivery of Luteinizing Hormone-releasing Hormone with Chitosan Microneedles: A Promising Tool for Androgen Deprivation Therapy.

Chen MY, Chen YY, Tsai HT, Tzai TS, Chen MC, Tsai YS

Anticancer research1 Dec 2017Cited by 15 (Europe PMC)

PMID29187457 (opens in a new tab)DOI10.21873/anticanres.12139 (opens in a new tab)PepBankPUB-29187457
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In mice, goserelin microneedles initially increased serum LH, which declined below baseline at day 7.

    In plain wordsIn mice, goserelin microneedles first raised LH, then lowered it below baseline at day 7.

    Peptide
    Goserelin
    Outcome
    MixedSerum LH
    Study

    mousen: not reported in source

    Mice receiving goserelin-containing chitosan microneedles
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · transdermalAs given in this study (mouse).

    Source sentences

    Summary
    After applying goserelin-containing microneedles to mice, serum LH levels increased initially and then declined below baseline at day 7.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In mice given goserelin microneedles, testosterone peaked at day 14 and declined to a castration level at day 21.

    In plain wordsIn mice given goserelin microneedles, testosterone peaked at day 14 and fell to a castration level at day 21.

    Peptide
    Goserelin
    Outcome
    MixedSerum testosterone
    Study

    mousen: not reported in source

    Mice receiving goserelin-containing chitosan microneedles
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · transdermalAs given in this study (mouse).

    Source sentences

    Summary
    In contrast, serum testosterone levels increased to reach a peak at day 14 and then declined to a castration level at day 21.
    1 context sentence
    Summary · context
    After applying goserelin-containing microneedles to mice, serum LH levels increased initially and then declined below baseline at day 7.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In mice given goserelin microneedles, castration-level testosterone persisted for 2 weeks.

    In plain wordsIn mice given goserelin microneedles, testosterone stayed at a castration level for 2 weeks.

    Peptide
    Goserelin
    Outcome
    Not applicableDuration of castration-level testosterone
    Study

    mousen: not reported in source

    Mice receiving goserelin-containing chitosan microneedles
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · transdermalAs given in this study (mouse).

    Source sentences

    Summary
    Additionally, such a castration level was maintained for 2 weeks.
    2 context sentences
    Summary · context
    In contrast, serum testosterone levels increased to reach a peak at day 14 and then declined to a castration level at day 21.
    Summary · context
    After applying goserelin-containing microneedles to mice, serum LH levels increased initially and then declined below baseline at day 7.

Studies that did not test the peptide alone1

In this study, Goserelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Goserelin.

  1. 04LabNot a test of Goserelin aloneIn vitro (cell-free)Other

    In laboratory tests, the goserelin-containing microneedle patch had an LHRHa loading amount of 73.3±2.8 μg per patch.

    In plain wordsIn lab tests, goserelin-containing microneedle patches held 73.3±2.8 μg of the hormone analogue per patch.

    Peptide
    Goserelin
    Outcome
    Not applicableMicroneedle patch peptide loading
    Study

    n: not reported in source

    Chitosan microneedle patch
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Measurements

    LHRHa loading amount
    73.3 μg per patch
    reported spread ±2.8 μg per patch

    Source sentences

    Summary
    The measured LHRHa loading amount was 73.3±2.8 μg per microneedle patch.
    1 context sentence
    Summary · context
    After applying goserelin-containing microneedles to mice, serum LH levels increased initially and then declined below baseline at day 7.

    In this study, Goserelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Goserelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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