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Study · Animal study (in vivo) · rat · 2017

11 results

Effects of cerebrolysin on nerve growth factor system in the aging rat brain.

Stepanichev M, Onufriev M, Aniol V, Freiman S, Brandstaetter H, Winter S, Lazareva N, Guekht A, Gulyaeva N

Restorative neurology and neuroscience1 Jan 2017Cited by 18 (Europe PMC)

PMID29172008 (opens in a new tab)PMCIDPMC5701766 (opens in a new tab)DOI10.3233/rnn-170724 (opens in a new tab)PepBankPUB-29172008
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In rats, CBL did not change general status compared with untreated rats.

    In plain wordsIn rats, CBL did not change general status compared with untreated rats.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeGeneral status
    Study

    ratn: not reported in source

    Old and young male Wistar rats
    Comparator
    Untreated rats
    Outcome group
    Adverse events · Whole body
    Studied dose
    2.5 ml/kg · i.p.As given in this study (rat).

    Source sentences

    Summary
    CBL treatment did not affect general status, age-related weight changes, general locomotor activity as well as general brain histology.
    2 context sentences
    Summary · context
    Old (23-24 months) and young (2-3 months) male Wistar rats were used for the study.
    Summary · context
    A half of animals were subjected to CBL course (2.5 ml/kg, 20 i.p. injections).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, CBL did not change age-related weight changes compared with untreated rats.

    In plain wordsIn rats, CBL did not change age-related weight changes compared with untreated rats.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeAge-related weight changes
    Study

    ratn: not reported in source

    Old and young male Wistar rats
    Comparator
    Untreated rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    2.5 ml/kg · i.p.As given in this study (rat).

    Source sentences

    Summary
    CBL treatment did not affect general status, age-related weight changes, general locomotor activity as well as general brain histology.
    2 context sentences
    Summary · context
    Old (23-24 months) and young (2-3 months) male Wistar rats were used for the study.
    Summary · context
    A half of animals were subjected to CBL course (2.5 ml/kg, 20 i.p. injections).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, CBL did not change locomotor activity compared with untreated rats.

    In plain wordsIn rats, CBL did not change locomotor activity compared with untreated rats.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeGeneral locomotor activity
    Study

    ratn: not reported in source

    Old and young male Wistar rats
    Comparator
    Untreated rats
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    2.5 ml/kg · i.p.As given in this study (rat).

    Source sentences

    Summary
    CBL treatment did not affect general status, age-related weight changes, general locomotor activity as well as general brain histology.
    2 context sentences
    Summary · context
    Old (23-24 months) and young (2-3 months) male Wistar rats were used for the study.
    Summary · context
    A half of animals were subjected to CBL course (2.5 ml/kg, 20 i.p. injections).
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In rats, CBL did not change brain tissue structure compared with untreated rats.

    In plain wordsIn rats, CBL did not change brain tissue structure compared with untreated rats.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeGeneral brain histology
    Study

    ratn: not reported in source

    Old and young male Wistar rats
    Comparator
    Untreated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · i.p.As given in this study (rat).

    Source sentences

    Summary
    CBL treatment did not affect general status, age-related weight changes, general locomotor activity as well as general brain histology.
    2 context sentences
    Summary · context
    Old (23-24 months) and young (2-3 months) male Wistar rats were used for the study.
    Summary · context
    A half of animals were subjected to CBL course (2.5 ml/kg, 20 i.p. injections).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In old rats, CBL had a minor effect at the start of water maze training compared with untreated rats.

    In plain wordsIn old rats, CBL had a minor effect at the start of water maze training compared with untreated rats.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedWater maze training start
    Study

    ratn: not reported in source

    Old male Wistar rats
    Comparator
    Untreated rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg · i.p.As given in this study (rat).

    Source sentences

    Summary
    In a water maze task, a minor effect of CBL was observed in old rats at the start of training and no effect on memory retention was found.
    2 context sentences
    Summary · context
    Old (23-24 months) and young (2-3 months) male Wistar rats were used for the study.
    Summary · context
    A half of animals were subjected to CBL course (2.5 ml/kg, 20 i.p. injections).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, CBL did not change water maze memory retention compared with untreated rats.

    In plain wordsIn rats, CBL did not change water maze memory retention compared with untreated rats.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeMemory retention
    Study

    ratn: not reported in source

    Old and young male Wistar rats
    Comparator
    Untreated rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg · i.p.As given in this study (rat).

    Source sentences

    Summary
    In a water maze task, a minor effect of CBL was observed in old rats at the start of training and no effect on memory retention was found.
    2 context sentences
    Summary · context
    Old (23-24 months) and young (2-3 months) male Wistar rats were used for the study.
    Summary · context
    A half of animals were subjected to CBL course (2.5 ml/kg, 20 i.p. injections).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats, CBL counteracted age-related decreases in neocortical TrkA receptors compared with untreated rats.

    In plain wordsIn rats, CBL counteracted age-related decreases in neocortical TrkA receptors compared with untreated rats.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeocortical TrkA receptors
    Study

    ratn: not reported in source

    Old and young male Wistar rats
    Comparator
    Untreated rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 ml/kg · i.p.As given in this study (rat).

    Source sentences

    Summary
    CBL counteracted effects of aging on neocortical TrkA and p75NTR receptors and decreased expression of proNGF without influencing overall NGF levels.
    3 context sentences
    Summary · context
    Aging induced a decrease in neurotrophin receptors TrkA, TrkB, and p75NTR in the neocortex.
    Summary · context
    Old (23-24 months) and young (2-3 months) male Wistar rats were used for the study.
    Summary · context
    A half of animals were subjected to CBL course (2.5 ml/kg, 20 i.p. injections).
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats, CBL counteracted age-related decreases in neocortical p75NTR receptors compared with untreated rats.

    In plain wordsIn rats, CBL counteracted age-related decreases in neocortical p75NTR receptors compared with untreated rats.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeocortical p75NTR receptors
    Study

    ratn: not reported in source

    Old and young male Wistar rats
    Comparator
    Untreated rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 ml/kg · i.p.As given in this study (rat).

    Source sentences

    Summary
    CBL counteracted effects of aging on neocortical TrkA and p75NTR receptors and decreased expression of proNGF without influencing overall NGF levels.
    3 context sentences
    Summary · context
    Aging induced a decrease in neurotrophin receptors TrkA, TrkB, and p75NTR in the neocortex.
    Summary · context
    Old (23-24 months) and young (2-3 months) male Wistar rats were used for the study.
    Summary · context
    A half of animals were subjected to CBL course (2.5 ml/kg, 20 i.p. injections).
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats, CBL reduced neocortical proNGF expression compared with untreated rats.

    In plain wordsIn rats, CBL reduced neocortical proNGF expression compared with untreated rats.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseproNGF expression
    Study

    ratn: not reported in source

    Old and young male Wistar rats
    Comparator
    Untreated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · i.p.As given in this study (rat).

    Source sentences

    Summary
    CBL counteracted effects of aging on neocortical TrkA and p75NTR receptors and decreased expression of proNGF without influencing overall NGF levels.
    2 context sentences
    Summary · context
    Old (23-24 months) and young (2-3 months) male Wistar rats were used for the study.
    Summary · context
    A half of animals were subjected to CBL course (2.5 ml/kg, 20 i.p. injections).
  10. 10AnimalAnimal study (in vivo)Mechanism

    In rats, CBL did not change overall neocortical NGF levels compared with untreated rats.

    In plain wordsIn rats, CBL did not change overall neocortical NGF levels compared with untreated rats.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeOverall NGF levels
    Study

    ratn: not reported in source

    Old and young male Wistar rats
    Comparator
    Untreated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · i.p.As given in this study (rat).

    Source sentences

    Summary
    CBL counteracted effects of aging on neocortical TrkA and p75NTR receptors and decreased expression of proNGF without influencing overall NGF levels.
    2 context sentences
    Summary · context
    Old (23-24 months) and young (2-3 months) male Wistar rats were used for the study.
    Summary · context
    A half of animals were subjected to CBL course (2.5 ml/kg, 20 i.p. injections).
  11. 11AnimalAnimal study (in vivo)Mechanism

    In rats, CBL did not significantly affect the BDNF system compared with untreated rats.

    In plain wordsIn rats, CBL did not significantly affect the BDNF system compared with untreated rats.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeBDNF system
    Study

    ratn: not reported in source

    Old and young male Wistar rats
    Comparator
    Untreated rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg · i.p.As given in this study (rat).

    Source sentences

    Summary
    BDNF system was not significantly affected by CBL.
    2 context sentences
    Summary · context
    Old (23-24 months) and young (2-3 months) male Wistar rats were used for the study.
    Summary · context
    A half of animals were subjected to CBL course (2.5 ml/kg, 20 i.p. injections).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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