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Study · Not a test of the peptide alone · 2018

13 results

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.

Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ

Biochemical pharmacology15 Nov 2017Cited by 77 (Europe PMC)

PMID29155147 (opens in a new tab)PMCIDPMC5826726 (opens in a new tab)DOI10.1016/j.bcp.2017.11.007 (opens in a new tab)PepBankPUB-29155147
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone13

In this study, 5-amino-1MQ was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking 5-amino-1MQ.

  1. 01AnimalNot a test of 5-amino-1MQ aloneAnimal study (in vivo)Efficacy outcome

    In obese mice, an unnamed potent NNMT inhibitor significantly reduced body weight.

    In plain wordsIn obese mice, an unnamed potent NNMT inhibitor significantly reduced body weight.

    Peptide
    5-amino-1MQ
    Outcome
    DecreaseBody weight
    Study

    mousen: not reported in source

    diet-induced obese mice
    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    Treatment of diet-induced obese mice systemically with a potent NNMT inhibitor significantly reduced body weight and white adipose mass, decreased adipocyte size, and lowered plasma total cholesterol levels.

    In this study, 5-amino-1MQ was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking 5-amino-1MQ.

  2. 02AnimalNot a test of 5-amino-1MQ aloneAnimal study (in vivo)Efficacy outcome

    In obese mice, an unnamed potent NNMT inhibitor significantly reduced white adipose mass.

    In plain wordsIn obese mice, an unnamed potent NNMT inhibitor significantly reduced white fat mass.

    Peptide
    5-amino-1MQ
    Outcome
    DecreaseWhite adipose mass
    Study

    mousen: not reported in source

    diet-induced obese mice
    Outcome group
    Body composition · Metabolic and weight

    Source sentences

    Summary
    Treatment of diet-induced obese mice systemically with a potent NNMT inhibitor significantly reduced body weight and white adipose mass, decreased adipocyte size, and lowered plasma total cholesterol levels.

    In this study, 5-amino-1MQ was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking 5-amino-1MQ.

  3. 03AnimalNot a test of 5-amino-1MQ aloneAnimal study (in vivo)Efficacy outcome

    In obese mice, an unnamed potent NNMT inhibitor decreased adipocyte size.

    In plain wordsIn obese mice, an unnamed potent NNMT inhibitor decreased fat cell size.

    Peptide
    5-amino-1MQ
    Outcome
    DecreaseAdipocyte size
    Study

    mousen: not reported in source

    diet-induced obese mice
    Outcome group
    Body composition · Metabolic and weight

    Source sentences

    Summary
    Treatment of diet-induced obese mice systemically with a potent NNMT inhibitor significantly reduced body weight and white adipose mass, decreased adipocyte size, and lowered plasma total cholesterol levels.

    In this study, 5-amino-1MQ was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking 5-amino-1MQ.

  4. 04AnimalNot a test of 5-amino-1MQ aloneAnimal study (in vivo)Efficacy outcome

    In obese mice, an unnamed potent NNMT inhibitor lowered plasma total cholesterol.

    In plain wordsIn obese mice, an unnamed potent NNMT inhibitor lowered plasma total cholesterol.

    Peptide
    5-amino-1MQ
    Outcome
    DecreasePlasma total cholesterol
    Study

    mousen: not reported in source

    diet-induced obese mice
    Outcome group
    Lipids · Metabolic and weight

    Source sentences

    Summary
    Treatment of diet-induced obese mice systemically with a potent NNMT inhibitor significantly reduced body weight and white adipose mass, decreased adipocyte size, and lowered plasma total cholesterol levels.

    In this study, 5-amino-1MQ was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking 5-amino-1MQ.

  5. 05AnimalNot a test of 5-amino-1MQ aloneAnimal study (in vivo)Efficacy outcome

    In obese mice, NNMT inhibitor administration did not affect total food intake.

    In plain wordsIn obese mice, NNMT inhibitor administration did not affect total food intake.

    Peptide
    5-amino-1MQ
    Outcome
    No significant changeTotal food intake
    Study

    mousen: not reported in source

    diet-induced obese mice
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    Notably, administration of NNMT inhibitors did not impact total food intake nor produce any observable adverse effects.
    1 context sentence
    Summary · context
    Effects of a potent NNMT inhibitor on obesity measures and plasma lipid were assessed in diet-induced obese mice fed a high-fat diet.

    In this study, 5-amino-1MQ was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking 5-amino-1MQ.

  6. 06AnimalNot a test of 5-amino-1MQ aloneAnimal study (in vivo)Safety outcome

    In obese mice, NNMT inhibitor administration produced no observable adverse effects.

    In plain wordsIn obese mice, NNMT inhibitor administration produced no observable adverse effects.

    Peptide
    5-amino-1MQ
    Outcome
    No significant changeObservable adverse effects
    Study

    mousen: not reported in source

    diet-induced obese mice
    Outcome group
    Adverse events · Whole body

    Source sentences

    Summary
    Notably, administration of NNMT inhibitors did not impact total food intake nor produce any observable adverse effects.
    1 context sentence
    Summary · context
    Effects of a potent NNMT inhibitor on obesity measures and plasma lipid were assessed in diet-induced obese mice fed a high-fat diet.

    In this study, 5-amino-1MQ was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking 5-amino-1MQ.

  7. 07LabNot a test of 5-amino-1MQ aloneIn vitro (cells)Mechanism

    In adipocytes, NNMT inhibitor treatments reduced intracellular 1-MNA.

    In plain wordsIn cells, NNMT inhibitor treatments reduced intracellular 1-MNA in adipocytes.

    Peptide
    5-amino-1MQ
    Outcome
    DecreaseIntracellular 1-MNA
    Study

    n: not reported in source

    cultured adipocytes
    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    NNMT inhibitors reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5'-adenosyl)-l-methionine (SAM), and suppressed lipogenesis in adipocytes.

    In this study, 5-amino-1MQ was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking 5-amino-1MQ.

  8. 08LabNot a test of 5-amino-1MQ aloneIn vitro (cells)Mechanism

    In adipocytes, NNMT inhibitor treatments increased intracellular NAD.

    In plain wordsIn cells, NNMT inhibitor treatments increased intracellular NAD in adipocytes.

    Peptide
    5-amino-1MQ
    Outcome
    IncreaseIntracellular NAD
    Study

    n: not reported in source

    cultured adipocytes
    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    NNMT inhibitors reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5'-adenosyl)-l-methionine (SAM), and suppressed lipogenesis in adipocytes.

    In this study, 5-amino-1MQ was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking 5-amino-1MQ.

  9. 09LabNot a test of 5-amino-1MQ aloneIn vitro (cells)Mechanism

    In adipocytes, NNMT inhibitor treatments increased intracellular SAM.

    In plain wordsIn cells, NNMT inhibitor treatments increased intracellular SAM in adipocytes.

    Peptide
    5-amino-1MQ
    Outcome
    IncreaseIntracellular SAM
    Study

    n: not reported in source

    cultured adipocytes
    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    NNMT inhibitors reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5'-adenosyl)-l-methionine (SAM), and suppressed lipogenesis in adipocytes.

    In this study, 5-amino-1MQ was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking 5-amino-1MQ.

  10. 10LabNot a test of 5-amino-1MQ aloneIn vitro (cells)Efficacy outcome

    In adipocytes, NNMT inhibitor treatments suppressed lipogenesis.

    In plain wordsIn cells, NNMT inhibitor treatments suppressed fat production in adipocytes.

    Peptide
    5-amino-1MQ
    Outcome
    DecreaseLipogenesis
    Study

    n: not reported in source

    cultured adipocytes
    Outcome group
    Lipids · Metabolic and weight

    Source sentences

    Summary
    NNMT inhibitors reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5'-adenosyl)-l-methionine (SAM), and suppressed lipogenesis in adipocytes.

    In this study, 5-amino-1MQ was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking 5-amino-1MQ.

  11. 11LabNot a test of 5-amino-1MQ aloneIn vitro (cell-free)Activity measurement

    In lab tests, primary amine-substituted methylquinolinium scaffolds showed high membrane permeability through passive and active transport.

    In plain wordsIn lab tests, primary amine-substituted methylquinolinium scaffolds showed high membrane permeability through passive and active transport.

    Peptide
    5-amino-1MQ
    Outcome
    Not applicableMembrane permeability
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Methylquinolinium scaffolds with primary amine substitutions displayed high permeability from passive and active transport across membranes.
    1 context sentence
    Summary · context
    Membrane permeability of NNMT inhibitors was characterized using parallel artificial membrane permeability and Caco-2 cell assays.

    In this study, 5-amino-1MQ was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking 5-amino-1MQ.

  12. 12LabNot a test of 5-amino-1MQ aloneIn vitro (cell-free)Activity measurement

    In lab tests, methylquinolinium analogues did not inhibit related SAM-dependent methyltransferases.

    In plain wordsIn lab tests, methylquinolinium analogues did not inhibit related SAM-dependent methyltransferases.

    Peptide
    5-amino-1MQ
    Outcome
    No significant changeRelated methyltransferase inhibition
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Importantly, methylquinolinium analogues displayed high selectivity, not inhibiting related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway.

    In this study, 5-amino-1MQ was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking 5-amino-1MQ.

  13. 13LabNot a test of 5-amino-1MQ aloneIn vitro (cell-free)Activity measurement

    In lab tests, methylquinolinium analogues did not inhibit enzymes in the NAD salvage pathway.

    In plain wordsIn lab tests, methylquinolinium analogues did not inhibit enzymes in the NAD salvage pathway.

    Peptide
    5-amino-1MQ
    Outcome
    No significant changeNAD salvage enzyme inhibition
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Importantly, methylquinolinium analogues displayed high selectivity, not inhibiting related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway.

    In this study, 5-amino-1MQ was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking 5-amino-1MQ.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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