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Study · Ex vivo tissue · mouse · 2017

4 results

Aging-Induced Modulation of Pituitary Adenylate Cyclase-Activating Peptide- and Vasoactive Intestinal Peptide-Induced Vasomotor Responses in the Arteries of Mice.

Ivic I, Solymar M, Fulop BD, Hashimoto H, Toth G, Tamas A, Juhasz T, Koller A, Reglodi D

Journal of vascular research9 Nov 2017Cited by 3 (Europe PMC)

PMID29131060 (opens in a new tab)DOI10.1159/000481781 (opens in a new tab)PepBankPUB-29131060
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In isolated carotid arteries of young wild-type mice, VIP induced relaxation.

    In plain wordsIn lab tests on mouse arteries, VIP relaxed the arteries of young normal mice.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseVIP-induced relaxation in young wild-type arteries
    Study

    mousen: not reported in source

    Isolated carotid arteries from wild-type and PACAP-KO mice
    Comparator
    Baseline tone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    All peptides induced relaxation in the arteries of young WT mice
    1 context sentence
    Summary · context
    Thus, we investigated the effects of exogenous VIP and PACAP peptides in isolated carotid arteries of 2- and 15-month-old wild-type (WT) and PACAP-KO mice.
  2. 02LabEx vivo tissueActivity measurement

    In isolated carotid arteries of young PACAP-KO mice, VIP induced relaxation.

    In plain wordsIn lab tests on mouse arteries, VIP relaxed the arteries of young mice that lack PACAP.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseVIP-induced relaxation in young PACAP-KO arteries
    Study

    mousen: not reported in source

    Isolated carotid arteries from wild-type and PACAP-KO mice
    Comparator
    Baseline tone
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    in young PACAP-KO mice PACAP1-27 and VIP, but not PACAP1-38, induced relaxation.
    1 context sentence
    Summary · context
    Thus, we investigated the effects of exogenous VIP and PACAP peptides in isolated carotid arteries of 2- and 15-month-old wild-type (WT) and PACAP-KO mice.
  3. 03LabEx vivo tissueActivity measurement

    In isolated carotid arteries of aging wild-type mice, the VIP-induced vasomotor response was not reduced, unlike the PACAP-induced responses.

    In plain wordsIn lab tests on mouse arteries, VIP responses did not weaken with age in normal mice, unlike PACAP responses.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeVIP-induced response in aging wild-type arteries
    Study

    mousen: not reported in source

    Isolated carotid arteries from wild-type and PACAP-KO mice
    Comparator
    Young wild-type arteries
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Unlike VIP, PACAP-induced vasomotor responses were reduced in aging WT mice.
    1 context sentence
    Summary · context
    Thus, we investigated the effects of exogenous VIP and PACAP peptides in isolated carotid arteries of 2- and 15-month-old wild-type (WT) and PACAP-KO mice.
  4. 04LabEx vivo tissueActivity measurement

    In isolated carotid arteries of aging PACAP-KO mice, the VIP-induced response was reduced compared with young PACAP-KO mice.

    In plain wordsIn lab tests on mouse arteries, VIP responses were weaker in older mice that lack PACAP than in younger ones.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseVIP-induced response in aging PACAP-KO arteries
    Study

    mousen: not reported in source

    Isolated carotid arteries from wild-type and PACAP-KO mice
    Comparator
    Young PACAP-KO arteries
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    in the arteries of aging PACAP-KO mice, PACAP1-27- and VIP-induced responses were reduced
    1 context sentence
    Summary · context
    Thus, we investigated the effects of exogenous VIP and PACAP peptides in isolated carotid arteries of 2- and 15-month-old wild-type (WT) and PACAP-KO mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:40 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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