Studying the Toxic Effects of Some Biologically Active Peptides on the Model of Mouse Embryonic Stem Cells.

Kobylyanskii AG, Zolotarev YA, Andreeva LA, Grivennikov IA, Myasoedov NF

Bulletin of experimental biology and medicine24 Oct 2017

PMID29063333DOI10.1007/s10517-017-3891-yPepBankPUB-29063333

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In mouse embryonic stem cells, Selank had an insignificant effect on differentiation into mature neurons.
In plain wordsIn cells, Selank had no significant effect on how mouse stem cells developed into mature neurons.
Peptide
Selank
Outcome
No significant changeDifferentiation into mature neurons
Study
mousen: not reported in source
Mouse embryonic stem cells
Comparator
Control
Outcome group
Cell proliferation and differentiation · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
HLDF-6, Selank, and thyroliberin produced an insignificant effect on the differentiation of these cells into mature neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effects of peptide drugs (HLDF-6, PGP, RPGP, and PGLP) and peptide pharmaceutical products (Semax, Selank, and thyroliberin) on proliferation and survival of mouse embryonic stem cells and their derivatives.
Report a problemFND-2906333301
02LabIn vitro (cells)Activity measurement
In mouse embryonic stem cells, Selank decreased the ratio of GABA-positive neurons by 61% compared with control.
In plain wordsIn cells, Selank lowered the share of mouse stem cells that became GABA-positive neurons by 61% compared with control.
Peptide
Selank
Outcome
DecreaseRatio of GABA+ neurons from stem cell differentiation
Study
mousen: not reported in source
Mouse embryonic stem cells
Comparator
Control
Outcome group
Cell proliferation and differentiation · Nervous system and cognition
Studied dose
Dose not stated
Measurements
Reduction in GABA+ neuron ratio
61%
Selank versus control
Source sentences
Summary
Analysis of differentiation of embryonic stem cells into GABA⁺ neurons showed that Selank, thyroliberin (100 μM), and NGF (100 ng/ml) decrease the ratio of these cells by 61, 58, and 87%, respectively, in comparison with the control.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effects of peptide drugs (HLDF-6, PGP, RPGP, and PGLP) and peptide pharmaceutical products (Semax, Selank, and thyroliberin) on proliferation and survival of mouse embryonic stem cells and their derivatives.
Report a problemFND-2906333302
03LabIn vitro (cells)Efficacy outcome
In mouse embryonic stem cells under serum deprivation, Semax at 10 and 0.1 µM significantly increased the survival rate.
In plain wordsIn cells, Semax raised the survival of mouse embryonic stem cells deprived of serum.
Peptide
Semax
Outcome
IncreaseSurvival of embryonic stem cells under serum deprivation
Study
mousen: not reported in source
mouse embryonic stem cells
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
10 and 0.1 µMAs given in this study (mouse).
Source sentences
Summary
These peptides in concentrations of 10 and 0.1 μM, respectively, and Semax (10 and 0.1 μM) significantly increased the survival rate of mouse embryonic stem cells (serum deprivation).
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effects of peptide drugs (HLDF-6, PGP, RPGP, and PGLP) and peptide pharmaceutical products (Semax, Selank, and thyroliberin) on proliferation and survival of mouse embryonic stem cells and their derivatives.
Report a problemFND-2906333303

Studies that did not test the peptide alone1

In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Semax.

04LabNot a test of Semax aloneIn vitro (cells)Efficacy outcome
In mouse embryonic stem cells, the study peptides pooled (including Semax) had little effect on the formation of neuronal precursors.
In plain wordsIn cells, the tested peptides as a group had little effect on the formation of neuron precursors.
Peptide
Semax
Outcome
Direction not reportedFormation of neuronal precursors
Study
mousen: not reported in source
mouse embryonic stem cells
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Moreover, study peptides had little effect on the formation of neuronal precursors from mouse embryonic stem cells.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied the effects of peptide drugs (HLDF-6, PGP, RPGP, and PGLP) and peptide pharmaceutical products (Semax, Selank, and thyroliberin) on proliferation and survival of mouse embryonic stem cells and their derivatives.
In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.
Report a problemFND-2906333304

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 3 to 38Current
28 Oct 2026, 02:04 UTC
The same notice was added 36 times, first on 9 Oct 2026, 19:08 UTC. The status did not change between them.
Study results updated
Version 2
9 Oct 2026, 03:04 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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