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Study · Not a test of the peptide alone · 2017

3 results

Influences of Histidine-1 and Azaphenylalanine-4 on the Affinity, Anti-inflammatory, and Antiangiogenic Activities of Azapeptide Cluster of Differentiation 36 Receptor Modulators.

Chignen Possi K, Mulumba M, Omri S, Garcia-Ramos Y, Tahiri H, Chemtob S, Ong H, Lubell WD

Journal of medicinal chemistry1 Nov 2017Cited by 10 (Europe PMC)

PMID29028172 (opens in a new tab)DOI10.1021/acs.jmedchem.7b01209 (opens in a new tab)PepBankPUB-29028172
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01LabNot a test of GHRP-6 aloneIn vitro (cells)Activity measurement

    In macrophages, GHRP‑6 azapeptide analogues differed significantly in their ability to modulate nitric oxide production.

    In plain wordsIn cells, modified GHRP‑6 analogues differed in their effects on nitric oxide production.

    Peptide
    GHRP-6
    Outcome
    MixedMacrophage nitric oxide production
    Study

    n: not reported in source

    GHRP-6 azapeptide analogues
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    Although their binding affinities differed only by a factor of 17, the analogues exhibited significant differences in ability to modulate production of nitric oxide (NO) in macrophages and choroidal neovascularization.
    1 context sentence
    Summary · context
    The influences of the 1- and 4-position residues on the affinity, anti-inflammatory, and antiangiogenic activity of these azapeptides have now been studied in detail by the synthesis and analysis of a set of 25 analogues featuring Ala1 or His1 and a variety of aromatic side cha…

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02LabNot a test of GHRP-6 aloneIn vitro (cell-free)Activity measurement

    In lab tests, GHRP‑6 azapeptide analogues differed in binding affinity by a factor of 17.

    In plain wordsIn lab tests, modified GHRP‑6 analogues differed in binding affinity by a factor of 17.

    Peptide
    GHRP-6
    Outcome
    MixedCD36 binding affinity variation
    Study

    n: not reported in source

    GHRP-6 azapeptide analogues
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Measurements

    Affinity variation
    17 fold
    azapeptide analogues

    Source sentences

    Summary
    Although their binding affinities differed only by a factor of 17,
    1 context sentence
    Summary · context
    The influences of the 1- and 4-position residues on the affinity, anti-inflammatory, and antiangiogenic activity of these azapeptides have now been studied in detail by the synthesis and analysis of a set of 25 analogues featuring Ala1 or His1 and a variety of aromatic side cha…

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 03LabNot a test of GHRP-6 aloneOther designActivity measurement

    In choroidal assays, GHRP‑6 azapeptide analogues differed significantly in their ability to modulate neovascularization.

    In plain wordsIn lab tests, modified GHRP‑6 analogues differed in their effects on choroidal vessel growth.

    Peptide
    GHRP-6
    Outcome
    MixedChoroidal neovascularization modulation
    Study

    n: not reported in source

    GHRP-6 azapeptide analogues
    Outcome group
    Angiogenesis · Eye

    Source sentences

    Summary
    Although their binding affinities differed only by a factor of 17, the analogues exhibited significant differences in ability to modulate production of nitric oxide (NO) in macrophages and choroidal neovascularization.
    1 context sentence
    Summary · context
    The influences of the 1- and 4-position residues on the affinity, anti-inflammatory, and antiangiogenic activity of these azapeptides have now been studied in detail by the synthesis and analysis of a set of 25 analogues featuring Ala1 or His1 and a variety of aromatic side cha…

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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