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Study · In vitro (cells) · 2018

5 results

Mechano growth factor E peptide inhibits invasion of melanoma cells and up-regulates CHOP expression via endoplasmic reticulum stress.

He J, Dong L, Xu K, Xu K, Qian Y, Wang C, Sha Y, Zhong JL, Liu W, Lv Y, Song Y, Yang L

Biotechnology letters6 Oct 2017Cited by 1 (Europe PMC)

PMID28986701 (opens in a new tab)DOI10.1007/s10529-017-2448-5 (opens in a new tab)PepBankPUB-28986701
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In GLL19 melanoma cells, MGF E peptide decreased invasive capability.

    In plain wordsIn melanoma cells in a dish, MGF E peptide reduced their ability to invade.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMelanoma cell invasion
    Study

    n: not reported in source

    GLL19 melanoma cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10, 20 and 30 ng/ml · 24 hAs given in this study.

    Source sentences

    Summary
    MGF decreased the invasive capabilities of melanoma cells and induced changes in cytoskeleton distribution.
    2 context sentences
    Summary · context
    Melanoma cells (GLL19) were treated with 10, 20 and 30 ng MGF/ml for 24 h.
    Summary · context
    Their invasive properties were investigated by transwell assay.
  2. 02LabIn vitro (cells)Mechanism

    In GLL19 melanoma cells, MGF E peptide induced changes in cytoskeleton distribution.

    In plain wordsIn melanoma cells in a dish, MGF E peptide changed how the cell skeleton was arranged.

    Peptide
    MGF / PEG-MGF
    Outcome
    Direction not reportedCytoskeleton distribution
    Study

    n: not reported in source

    GLL19 melanoma cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10, 20 and 30 ng/ml · 24 hAs given in this study.

    Source sentences

    Summary
    MGF decreased the invasive capabilities of melanoma cells and induced changes in cytoskeleton distribution.
    1 context sentence
    Summary · context
    Melanoma cells (GLL19) were treated with 10, 20 and 30 ng MGF/ml for 24 h.
  3. 03LabIn vitro (cells)Mechanism

    In GLL19 melanoma cells, MGF E peptide down-regulated the expression of matrix metalloproteinases.

    In plain wordsIn melanoma cells in a dish, MGF E peptide lowered levels of matrix metalloproteinases, enzymes linked to invasion.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMMP expression
    Study

    n: not reported in source

    GLL19 melanoma cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10, 20 and 30 ng/ml · 24 hAs given in this study.

    Source sentences

    Summary
    MGF also down-regulated the expression of MMPs and up-regulated the expression of the cell apoptosis-related protein CHOP by inducing ER stress.
    1 context sentence
    Summary · context
    Melanoma cells (GLL19) were treated with 10, 20 and 30 ng MGF/ml for 24 h.
  4. 04LabIn vitro (cells)Mechanism

    In GLL19 melanoma cells, MGF E peptide up-regulated the apoptosis-related protein CHOP.

    In plain wordsIn melanoma cells in a dish, MGF E peptide raised levels of CHOP, a cell death protein.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseCHOP expression
    Study

    n: not reported in source

    GLL19 melanoma cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10, 20 and 30 ng/ml · 24 hAs given in this study.

    Source sentences

    Summary
    MGF also down-regulated the expression of MMPs and up-regulated the expression of the cell apoptosis-related protein CHOP by inducing ER stress.
    1 context sentence
    Summary · context
    Melanoma cells (GLL19) were treated with 10, 20 and 30 ng MGF/ml for 24 h.
  5. 05LabIn vitro (cells)Mechanism

    In GLL19 melanoma cells, MGF E peptide induced endoplasmic reticulum stress.

    In plain wordsIn melanoma cells in a dish, MGF E peptide caused stress in the endoplasmic reticulum, a cell compartment.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseEndoplasmic reticulum stress
    Study

    n: not reported in source

    GLL19 melanoma cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    10, 20 and 30 ng/ml · 24 hAs given in this study.

    Source sentences

    Summary
    up-regulated the expression of the cell apoptosis-related protein CHOP by inducing ER stress.
    1 context sentence
    Summary · context
    Melanoma cells (GLL19) were treated with 10, 20 and 30 ng MGF/ml for 24 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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