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Study · Animal study (in vivo) · mouse · 2018

4 results

Comparative in Vivo Investigation of Intrathecal and Intracerebroventricular Administration with Melanocortin Ligands MTII and AGRP into Mice.

Adank DN, Lunzer MM, Lensing CJ, Wilber SL, Gancarz AM, Haskell-Luevano C

ACS chemical neuroscience19 Oct 2017Cited by 17 (Europe PMC)

PMID28968061 (opens in a new tab)PMCIDPMC5821609 (opens in a new tab)DOI10.1021/acschemneuro.7b00330 (opens in a new tab)PepBankPUB-28968061
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intrathecal MTII decreased food intake.

    In plain wordsIn mice, MTII given into the spinal canal reduced food intake.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake
    Study

    mousen: not reported in source

    age-matched mice in TSE metabolic cages, nocturnal satiated paradigm
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intrathecalAs given in this study (mouse).

    Source sentences

    Summary
    MTII IT administration caused a decrease in food and water intake
    1 context sentence
    Summary · context
    Herein, we investigate comparative IT and ICV administration of two melanocortin ligands, the synthetic MTII (Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2) MC4R agonist and agouti-related peptide [AGRP(87-132)] MC4R inverse agonist/antagonist, on the same batch of age-matched mice in TSE metabo…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intrathecal MTII decreased water intake.

    In plain wordsIn mice, MTII given into the spinal canal reduced water intake.

    Peptide
    Melanotan II
    Outcome
    DecreaseWater intake
    Study

    mousen: not reported in source

    age-matched mice in TSE metabolic cages, nocturnal satiated paradigm
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intrathecalAs given in this study (mouse).

    Source sentences

    Summary
    MTII IT administration caused a decrease in food and water intake
    1 context sentence
    Summary · context
    Herein, we investigate comparative IT and ICV administration of two melanocortin ligands, the synthetic MTII (Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2) MC4R agonist and agouti-related peptide [AGRP(87-132)] MC4R inverse agonist/antagonist, on the same batch of age-matched mice in TSE metabo…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intrathecal MTII produced an overall negative energy balance.

    In plain wordsIn mice, MTII given into the spinal canal led to a negative energy balance.

    Peptide
    Melanotan II
    Outcome
    DecreaseEnergy balance
    Study

    mousen: not reported in source

    age-matched mice in TSE metabolic cages, nocturnal satiated paradigm
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · intrathecalAs given in this study (mouse).

    Source sentences

    Summary
    an overall negative energy balance
    1 context sentence
    Summary · context
    Herein, we investigate comparative IT and ICV administration of two melanocortin ligands, the synthetic MTII (Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2) MC4R agonist and agouti-related peptide [AGRP(87-132)] MC4R inverse agonist/antagonist, on the same batch of age-matched mice in TSE metabo…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intrathecal MTII did not affect activity.

    In plain wordsIn mice, MTII given into the spinal canal did not change activity.

    Peptide
    Melanotan II
    Outcome
    No significant changeActivity
    Study

    mousen: not reported in source

    age-matched mice in TSE metabolic cages, nocturnal satiated paradigm
    Outcome group
    Exercise and physical function · Metabolic and weight
    Studied dose
    Dose not stated · intrathecalAs given in this study (mouse).

    Source sentences

    Summary
    without affecting activity.
    1 context sentence
    Summary · context
    Herein, we investigate comparative IT and ICV administration of two melanocortin ligands, the synthetic MTII (Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2) MC4R agonist and agouti-related peptide [AGRP(87-132)] MC4R inverse agonist/antagonist, on the same batch of age-matched mice in TSE metabo…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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