Effects of Intranasal Oxytocin on the Blood Oxygenation Level-Dependent Signal in Food Motivation and Cognitive Control Pathways in Overweight and Obese Men.

Plessow F, Marengi DA, Perry SK, Felicione JM, Franklin R, Holmes TM, Holsen LM, Makris N, Deckersbach T, Lawson EA

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20 Sept 2017Cited by 52 (Europe PMC)

PMID28930284PMCIDPMC5770767DOI10.1038/npp.2017.226PepBankPUB-28930284

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanRandomized controlled trialMechanism
In overweight or obese men, intranasal oxytocin reduced activation in hedonic food motivation regions (orbitofrontal cortex, insula, globus pallidus, putamen, hippocampus, amygdala) compared with placebo.
In plain wordsIn overweight or obese men, intranasal oxytocin lowered activity in several brain reward regions linked to food, compared with placebo.
Peptide
Oxytocin
Outcome
DecreaseHedonic food motivation regions BOLD signal
Study
n = 10
Comparator
Placebo
Analysis
Exploratory
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
24 IU · intranasalAs given in this study (human).
Source sentences
Summary
A secondary exploratory whole-brain analysis revealed hypoactivation in additional hedonic (orbitofrontal cortex, insula, globus pallidus, putamen, hippocampus, and amygdala) and homeostatic (hypothalamus) food motivation and hyperactivation in cognitive control (anterior cingulate and frontopolar c…
1 context sentence(design, population, supporting numbers)
Summary · context
We performed a randomized, double-blind, placebo-controlled crossover study with single-dose intranasal oxytocin (24 IU) in ten overweight or obese, otherwise healthy men.
Report a problemFND-2893028402
02HumanRandomized controlled trialMechanism
In overweight or obese men, intranasal oxytocin reduced hypothalamic activation in the homeostatic food motivation pathway compared with placebo.
In plain wordsIn overweight or obese men, intranasal oxytocin lowered activity in the hypothalamus, a brain region that controls hunger, compared with placebo.
Peptide
Oxytocin
Outcome
DecreaseHypothalamus (homeostatic) BOLD signal
Study
n = 10
Comparator
Placebo
Analysis
Exploratory
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
24 IU · intranasalAs given in this study (human).
Source sentences
Summary
A secondary exploratory whole-brain analysis revealed hypoactivation in additional hedonic (orbitofrontal cortex, insula, globus pallidus, putamen, hippocampus, and amygdala) and homeostatic (hypothalamus) food motivation and hyperactivation in cognitive control (anterior cingulate and frontopolar c…
1 context sentence(design, population, supporting numbers)
Summary · context
We performed a randomized, double-blind, placebo-controlled crossover study with single-dose intranasal oxytocin (24 IU) in ten overweight or obese, otherwise healthy men.
Report a problemFND-2893028403
03HumanRandomized controlled trialMechanism
In overweight or obese men, intranasal oxytocin increased activation in cognitive control regions (anterior cingulate and frontopolar cortex) compared with placebo.
In plain wordsIn overweight or obese men, intranasal oxytocin raised activity in brain regions for self-control, compared with placebo.
Peptide
Oxytocin
Outcome
IncreaseCognitive control regions BOLD signal
Study
n = 10
Comparator
Placebo
Analysis
Exploratory
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
24 IU · intranasalAs given in this study (human).
Source sentences
Summary
A secondary exploratory whole-brain analysis revealed hypoactivation in additional hedonic (orbitofrontal cortex, insula, globus pallidus, putamen, hippocampus, and amygdala) and homeostatic (hypothalamus) food motivation and hyperactivation in cognitive control (anterior cingulate and frontopolar c…
1 context sentence(design, population, supporting numbers)
Summary · context
We performed a randomized, double-blind, placebo-controlled crossover study with single-dose intranasal oxytocin (24 IU) in ten overweight or obese, otherwise healthy men.
Report a problemFND-2893028404
04HumanRandomized controlled trialMechanism
In overweight or obese men, intranasal oxytocin reduced bilateral ventral tegmental area activation to high-calorie food stimuli compared with placebo.
In plain wordsIn overweight or obese men, intranasal oxytocin lowered activity in a brain reward area when they saw high-calorie food, compared with placebo.
Peptide
Oxytocin
Outcome
DecreaseVentral tegmental area BOLD signal to high-calorie food stimuli
Study
n = 10
Comparator
Placebo
Outcome group
Brain and neuronal activity · Nervous system and cognition
Studied dose
24 IU · intranasalAs given in this study (human).
Source sentences
Summary
Following oxytocin administration, compared to placebo, participants showed bilateral VTA hypoactivation to high-calorie food stimuli.
1 context sentence(design, population, supporting numbers)
Summary · context
We performed a randomized, double-blind, placebo-controlled crossover study with single-dose intranasal oxytocin (24 IU) in ten overweight or obese, otherwise healthy men.
Report a problemFND-2893028401

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Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 2NCT06945926

The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery

Zhejiang Universityn = 2271 Jun 2025 to 2 Jun 2026

Cervical Spinal Stenosis · Thoracic Spinal Stenosis · Lumbar Spinal Stenosis · Rotator Cuff Injury · Femoral Head Necrosis · Spinal Trauma · Knee Joint Injury

Trial page ClinicalTrials.govUpdated 20 Aug 2026

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:48 UTC
First added · source update from Europe PMC

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