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Study · In vitro (cells) · 2017

5 results

MGF E peptide pretreatment improves the proliferation and osteogenic differentiation of BMSCs via MEK-ERK1/2 and PI3K-Akt pathway under severe hypoxia.

Sha Y, Lv Y, Xu Z, Yang L, Hao X, Afandi R

Life sciences18 Sept 2017Cited by 22 (Europe PMC)

PMID28927682 (opens in a new tab)DOI10.1016/j.lfs.2017.09.017 (opens in a new tab)PepBankPUB-28927682
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In BMSCs under simulated severe hypoxia, MGF E peptide inhibited HIF-1α expression and its transfer into the nucleus.

    In plain wordsIn cells, MGF E peptide lowered a low-oxygen stress protein in bone marrow stem cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseHIF-1α expression and nuclear translocation under hypoxia
    Study

    n: not reported in source

    BMSCs
    Comparator
    Hypoxia without peptide
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Fortunately, MGF E peptide inhibited HIF-1α expression and transferring into the nucleus.
    1 context sentence
    Summary · context
    CoCl2 was utilized to simulate severe hypoxia.
  2. 02LabIn vitro (cells)Efficacy outcome

    In BMSCs under simulated severe hypoxia, MGF E peptide pretreatment recovered cell proliferation.

    In plain wordsIn cells, MGF E peptide pretreatment restored growth of bone marrow stem cells under low-oxygen stress.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseBMSC proliferation under hypoxia
    Study

    n: not reported in source

    BMSCs
    Comparator
    Hypoxia without peptide
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cell proliferation and osteogenic differentiation of BMSCs
    2 context sentences
    Summary · context
    could be recovered by MGF E peptide pretreatment.
    Summary · context
    CoCl2 was utilized to simulate severe hypoxia.
  3. 03LabIn vitro (cells)Efficacy outcome

    In BMSCs under simulated severe hypoxia, MGF E peptide pretreatment recovered osteogenic differentiation.

    In plain wordsIn cells, MGF E peptide pretreatment restored bone-forming development of stem cells under low-oxygen stress.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseBMSC osteogenic differentiation under hypoxia
    Study

    n: not reported in source

    BMSCs
    Comparator
    Hypoxia without peptide
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cell proliferation and osteogenic differentiation of BMSCs could be recovered by MGF E peptide pretreatment.
    1 context sentence
    Summary · context
    CoCl2 was utilized to simulate severe hypoxia.
  4. 04LabIn vitro (cells)Mechanism

    In BMSCs under simulated severe hypoxia, the MEK-ERK1/2 and PI3K-Akt signaling pathways were involved in the effects of MGF E peptide.

    In plain wordsIn cells, two signal pathways took part in the effects of MGF E peptide on stem cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableMEK-ERK1/2 and PI3K-Akt pathway involvement
    Study

    n: not reported in source

    BMSCs
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MEK-ERK1/2 and PI3K-Akt signaling pathway were confirmed to be involved in MGF E peptide regulating the abovementioned indexes of BMSCs.
    1 context sentence
    Summary · context
    CoCl2 was utilized to simulate severe hypoxia.
  5. 05LabIn vitro (cells)Efficacy outcome

    In BMSCs, short-time treatment with MGF E peptide alone also promoted osteogenic differentiation.

    In plain wordsIn cells, a short treatment with MGF E peptide alone also promoted bone-forming development of stem cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseBMSC osteogenic differentiation with peptide alone
    Study

    n: not reported in source

    BMSCs
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    What's more, short-time treatment with MGF E peptide alone promoted the osteogenic differentiation of BMSCs as well.
    1 context sentence
    Summary · context
    CoCl2 was utilized to simulate severe hypoxia.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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