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Study · Randomized controlled trial · n = 86 · 2017

5 results

Sex-dependent neural effect of oxytocin during subliminal processing of negative emotion faces.

Luo L, Becker B, Geng Y, Zhao Z, Gao S, Zhao W, Yao S, Zheng X, Ma X, Gao Z, Hu J, Kendrick KM

NeuroImage4 Sept 2017Cited by 75 (Europe PMC)

PMID28877512 (opens in a new tab)DOI10.1016/j.neuroimage.2017.08.079 (opens in a new tab)PepBankPUB-28877512
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialMechanism

    Oxytocin produced sex-dependent effects on amygdala, anterior cingulate and inferior frontal gyrus functional connectivity versus placebo.

    In plain wordsOxytocin changed brain network connections differently in men and women, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    MixedFunctional connectivity of amygdala, anterior cingulate and inferior frontal gyrus
    Study

    n = 86

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    On the network level, sex-dependent effects were observed on amygdala, anterior cingulate and inferior frontal gyrus functional connectivity that were mainly driven by reduced coupling in women following OXT.
    1 context sentence
    Summary · context
    To explore whether sex-dependent effects already occur during early, subliminal, processing stages the present pharmacological fMRI-study combined the intranasal-application of either OXT or placebo (n = 86-43 males) with a backward-masking emotional face paradigm.
  2. 02HumanRandomized controlled trialMechanism

    In men, oxytocin suppressed inferior frontal gyrus, dorsal anterior cingulate and anterior insula responses to threatening face stimuli, versus placebo.

    In plain wordsIn men, oxytocin lowered brain responses to threatening faces in three regions, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseNeural responses to threatening faces (IFG, dACC, anterior insula) in men
    Study

    n = 43

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Results showed that while OXT suppressed inferior frontal gyrus, dorsal anterior cingulate and anterior insula responses to threatening face stimuli in men it increased them in women.
    1 context sentence
    Summary · context
    To explore whether sex-dependent effects already occur during early, subliminal, processing stages the present pharmacological fMRI-study combined the intranasal-application of either OXT or placebo (n = 86-43 males) with a backward-masking emotional face paradigm.
  3. 03HumanRandomized controlled trialMechanism

    In women, oxytocin increased inferior frontal gyrus, dorsal anterior cingulate and anterior insula responses to threatening face stimuli, versus placebo.

    In plain wordsIn women, oxytocin raised brain responses to threatening faces in three regions, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseNeural responses to threatening faces (IFG, dACC, anterior insula) in women
    Study

    n = 43

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Results showed that while OXT suppressed inferior frontal gyrus, dorsal anterior cingulate and anterior insula responses to threatening face stimuli in men it increased them in women.
    1 context sentence
    Summary · context
    To explore whether sex-dependent effects already occur during early, subliminal, processing stages the present pharmacological fMRI-study combined the intranasal-application of either OXT or placebo (n = 86-43 males) with a backward-masking emotional face paradigm.
  4. 04HumanRandomized controlled trialMechanism

    In women, the oxytocin-increased anterior cingulate reactivity during subliminal threat processing was positively associated with trait anxiety.

    In plain wordsIn women, a larger brain response to hidden threat faces under oxytocin was linked to higher trait anxiety.

    Peptide
    Oxytocin
    Outcome
    Not applicableAssociation of anterior cingulate reactivity with trait anxiety in women
    Study

    n = 43

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    In women increased anterior cingulate reactivity during subliminal threat processing was also positively associated with trait anxiety.
    1 context sentence
    Summary · context
    To explore whether sex-dependent effects already occur during early, subliminal, processing stages the present pharmacological fMRI-study combined the intranasal-application of either OXT or placebo (n = 86-43 males) with a backward-masking emotional face paradigm.
  5. 05HumanRandomized controlled trialMechanism

    In women, the sex-dependent connectivity effects were mainly driven by reduced coupling following oxytocin.

    In plain wordsIn women, oxytocin mainly reduced the coupling between brain regions, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseFunctional connectivity coupling in women
    Study

    n = 43

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    On the network level, sex-dependent effects were observed on amygdala, anterior cingulate and inferior frontal gyrus functional connectivity that were mainly driven by reduced coupling in women following OXT.
    1 context sentence
    Summary · context
    To explore whether sex-dependent effects already occur during early, subliminal, processing stages the present pharmacological fMRI-study combined the intranasal-application of either OXT or placebo (n = 86-43 males) with a backward-masking emotional face paradigm.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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