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Study · Randomized controlled trial · n = 51 · 2017

5 results

Oxytocin improves facial emotion recognition in young adults with antisocial personality disorder.

Timmermann M, Jeung H, Schmitt R, Boll S, Freitag CM, Bertsch K, Herpertz SC

Psychoneuroendocrinology5 Aug 2017Cited by 23 (Europe PMC)

PMID28865940 (opens in a new tab)DOI10.1016/j.psyneuen.2017.07.483 (opens in a new tab)PepBankPUB-28865940
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In young adults with ASPD and healthy controls, significant group by substance by emotion interactions were found in correct classifications and reaction times.

    In plain wordsIn adults with antisocial personality disorder and healthy adults, oxytocin and placebo changed face recognition differently by group and emotion.

    Peptide
    Oxytocin
    Outcome
    Not applicableInteraction of group, substance and emotion on correct classifications and reaction times
    Study

    n = 51

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Significant group×substance×emotion interactions were found in correct classifications and reaction times.
    1 context sentence
    Summary · context
    In a double-blind, randomized, placebo-controlled crossover trial, 22 individuals with ASPD and 29 healthy control (HC) subjects (matched for age, sex, intelligence, and education) were intranasally administered either OT (24 IU) or a placebo 45min before participating in an emotion classification p…
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy control subjects, reaction times for angry faces were longer after placebo than after oxytocin.

    In plain wordsIn healthy adults, reaction times to angry faces were longer after placebo than after oxytocin.

    Peptide
    Oxytocin
    Outcome
    DecreaseReaction time for angry faces in healthy controls
    Study

    n = 29

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    This effect was mainly driven by longer reaction times in HC subjects after placebo administration compared to OT administration
    1 context sentence
    Summary · context
    In a double-blind, randomized, placebo-controlled crossover trial, 22 individuals with ASPD and 29 healthy control (HC) subjects (matched for age, sex, intelligence, and education) were intranasally administered either OT (24 IU) or a placebo 45min before participating in an emotion classification p…
  3. 03HumanRandomized controlled trialEfficacy outcome

    In young adults with ASPD, the deficit in recognising fearful faces seen against healthy controls was no longer observable under oxytocin.

    In plain wordsIn young adults with antisocial personality disorder, a deficit in recognising fearful faces was no longer seen after oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseRecognition of fearful faces in ASPD
    Study

    n = 22

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Compared to HC, individuals with ASPD showed deficits in recognizing fearful and happy faces; these group differences were no longer observable under OT.
    1 context sentence
    Summary · context
    In a double-blind, randomized, placebo-controlled crossover trial, 22 individuals with ASPD and 29 healthy control (HC) subjects (matched for age, sex, intelligence, and education) were intranasally administered either OT (24 IU) or a placebo 45min before participating in an emotion classification p…
  4. 04HumanRandomized controlled trialEfficacy outcome

    In young adults with ASPD, the deficit in recognising happy faces seen against healthy controls was no longer observable under oxytocin.

    In plain wordsIn young adults with antisocial personality disorder, a deficit in recognising happy faces was no longer seen after oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseRecognition of happy faces in ASPD
    Study

    n = 22

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Compared to HC, individuals with ASPD showed deficits in recognizing fearful and happy faces; these group differences were no longer observable under OT.
    1 context sentence
    Summary · context
    In a double-blind, randomized, placebo-controlled crossover trial, 22 individuals with ASPD and 29 healthy control (HC) subjects (matched for age, sex, intelligence, and education) were intranasally administered either OT (24 IU) or a placebo 45min before participating in an emotion classification p…
  5. 05HumanRandomized controlled trialEfficacy outcome

    In individuals with ASPD, the reaction-time pattern for angry faces after oxytocin was descriptively the contrary of that in healthy controls, without a reported significant effect.

    In plain wordsIn people with antisocial personality disorder, reaction times to angry faces after oxytocin showed the opposite pattern to healthy adults, descriptively only.

    Peptide
    Oxytocin
    Outcome
    No significant changeReaction time for angry faces in ASPD
    Study

    n = 22

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    while individuals with ASPD revealed descriptively the contrary response pattern.
    1 context sentence
    Summary · context
    In a double-blind, randomized, placebo-controlled crossover trial, 22 individuals with ASPD and 29 healthy control (HC) subjects (matched for age, sex, intelligence, and education) were intranasally administered either OT (24 IU) or a placebo 45min before participating in an emotion classification p…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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