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Study · Animal study (in vivo) · wistar rat · 2017

11 results

Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress.

Fomenko EV, Bobyntsev II, Kryukov AA, Ivanov AV, Andreeva LA, Myasoedov NF

Bulletin of experimental biology and medicine29 Aug 2017Cited by 1 (Europe PMC)

PMID28853100 (opens in a new tab)DOI10.1007/s10517-017-3817-8 (opens in a new tab)PepBankPUB-28853100
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats under acute restraint stress, Selank at 100 and 300 μg/kg decreased catalase activity in liver homogenate.

    In plain wordsIn stressed rats, Selank lowered catalase activity in the liver.

    Peptide
    Selank
    Outcome
    DecreaseLiver catalase activity under acute restraint stress
    Study

    Wistar ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    100 and 300 μg/kg · intraperitonealAs given in this study (Wistar rat).

    Source sentences

    Summary
    Under conditions of acute restraint stress, Selank in doses of 100 and 300 μg/kg decreased catalase and superoxide dismutase activities and malondialdehyde concentration and increased total antioxidant activity in the liver homogenate.
    1 context sentence
    Summary · context
    We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats under acute restraint stress, Selank at 100 and 300 μg/kg decreased superoxide dismutase activity in liver homogenate.

    In plain wordsIn stressed rats, Selank lowered superoxide dismutase activity in the liver.

    Peptide
    Selank
    Outcome
    DecreaseLiver superoxide dismutase activity under acute restraint stress
    Study

    Wistar ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    100 and 300 μg/kg · intraperitonealAs given in this study (Wistar rat).

    Source sentences

    Summary
    Under conditions of acute restraint stress, Selank in doses of 100 and 300 μg/kg decreased catalase and superoxide dismutase activities and malondialdehyde concentration and increased total antioxidant activity in the liver homogenate.
    1 context sentence
    Summary · context
    We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats under acute restraint stress, Selank at 100 and 300 μg/kg decreased malondialdehyde concentration in liver homogenate.

    In plain wordsIn stressed rats, Selank lowered malondialdehyde, a marker of oxidative damage, in the liver.

    Peptide
    Selank
    Outcome
    DecreaseLiver malondialdehyde under acute restraint stress
    Study

    Wistar ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    100 and 300 μg/kg · intraperitonealAs given in this study (Wistar rat).

    Source sentences

    Summary
    Under conditions of acute restraint stress, Selank in doses of 100 and 300 μg/kg decreased catalase and superoxide dismutase activities and malondialdehyde concentration and increased total antioxidant activity in the liver homogenate.
    1 context sentence
    Summary · context
    We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats under acute restraint stress, Selank at 100 and 300 μg/kg increased total antioxidant activity in liver homogenate.

    In plain wordsIn stressed rats, Selank raised total antioxidant activity in the liver.

    Peptide
    Selank
    Outcome
    IncreaseLiver total antioxidant activity under acute restraint stress
    Study

    Wistar ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    100 and 300 μg/kg · intraperitonealAs given in this study (Wistar rat).

    Source sentences

    Summary
    Under conditions of acute restraint stress, Selank in doses of 100 and 300 μg/kg decreased catalase and superoxide dismutase activities and malondialdehyde concentration and increased total antioxidant activity in the liver homogenate.
    1 context sentence
    Summary · context
    We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats under acute restraint stress, Selank at 1000 μg/kg reduced the content of aminotransferases in blood serum.

    In plain wordsIn stressed rats, Selank at the highest dose lowered liver enzymes in the blood.

    Peptide
    Selank
    Outcome
    DecreaseSerum aminotransferases under acute restraint stress
    Study

    Wistar ratn: not reported in source

    Restraint stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    1000 μg/kg · intraperitonealAs given in this study (Wistar rat).

    Source sentences

    Summary
    Administration of Selank in a dose of 1000 μg/kg reduced the content of aminotransferases in blood serum, decreased superoxide dismutase activity in the liver, and increased total antioxidant activity.
    1 context sentence
    Summary · context
    We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, Selank at 1000 μg/kg decreased superoxide dismutase activity in the liver.

    In plain wordsIn rats, Selank at the highest dose lowered superoxide dismutase activity in the liver.

    Peptide
    Selank
    Outcome
    DecreaseLiver superoxide dismutase activity (1000 μg/kg)
    Study

    Wistar ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    1000 μg/kg · intraperitonealAs given in this study (Wistar rat).

    Source sentences

    Summary
    Administration of Selank in a dose of 1000 μg/kg reduced the content of aminotransferases in blood serum, decreased superoxide dismutase activity in the liver, and increased total antioxidant activity.
    1 context sentence
    Summary · context
    We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats, Selank at 1000 μg/kg increased total antioxidant activity in the liver.

    In plain wordsIn rats, Selank at the highest dose raised total antioxidant activity in the liver.

    Peptide
    Selank
    Outcome
    IncreaseLiver total antioxidant activity (1000 μg/kg)
    Study

    Wistar ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    1000 μg/kg · intraperitonealAs given in this study (Wistar rat).

    Source sentences

    Summary
    Administration of Selank in a dose of 1000 μg/kg reduced the content of aminotransferases in blood serum, decreased superoxide dismutase activity in the liver, and increased total antioxidant activity.
    1 context sentence
    Summary · context
    We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats under chronic stress, Selank at all doses reduced superoxide dismutase activity in liver tissue.

    In plain wordsIn rats under long-term stress, Selank at all doses lowered superoxide dismutase activity in the liver.

    Peptide
    Selank
    Outcome
    DecreaseLiver superoxide dismutase activity under chronic stress
    Study

    Wistar ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    100, 300 and 1000 μg/kg · intraperitonealAs given in this study (Wistar rat).

    Source sentences

    Summary
    Under conditions of chronic stress, Selank in all doses produced similar effects: reduced superoxide dismutase activity and malondialdehyde concentration in the liver tissue and AST activity in the serum.
    1 context sentence
    Summary · context
    We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats under chronic stress, Selank at all doses reduced malondialdehyde concentration in liver tissue.

    In plain wordsIn rats under long-term stress, Selank at all doses lowered malondialdehyde, a marker of oxidative damage, in the liver.

    Peptide
    Selank
    Outcome
    DecreaseLiver malondialdehyde under chronic stress
    Study

    Wistar ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    100, 300 and 1000 μg/kg · intraperitonealAs given in this study (Wistar rat).

    Source sentences

    Summary
    Under conditions of chronic stress, Selank in all doses produced similar effects: reduced superoxide dismutase activity and malondialdehyde concentration in the liver tissue and AST activity in the serum.
    1 context sentence
    Summary · context
    We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats under chronic stress, Selank at all doses reduced AST activity in serum.

    In plain wordsIn rats under long-term stress, Selank at all doses lowered the liver enzyme AST in the blood.

    Peptide
    Selank
    Outcome
    DecreaseSerum AST activity under chronic stress
    Study

    Wistar ratn: not reported in source

    Restraint stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    100, 300 and 1000 μg/kg · intraperitonealAs given in this study (Wistar rat).

    Source sentences

    Summary
    Under conditions of chronic stress, Selank in all doses produced similar effects: reduced superoxide dismutase activity and malondialdehyde concentration in the liver tissue and AST activity in the serum.
    1 context sentence
    Summary · context
    We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In rats under restraint stress, the other measured parameters remained unchanged with Selank.

    In plain wordsIn stressed rats, the other measured parameters did not change with Selank.

    Peptide
    Selank
    Outcome
    No significant changeOther measured parameters
    Study

    Wistar ratn: not reported in source

    Restraint stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    Dose not stated · intraperitonealAs given in this study (Wistar rat).

    Source sentences

    Summary
    The other parameters remained unchanged.
    1 context sentence
    Summary · context
    We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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