In male rats, Cerebrolysin prolonged morphine tolerance development to 10 days.
In plain wordsIn male rats, Cerebrolysin prolonged morphine tolerance development to 10 days.
- Peptide
- Cerebrolysin
- Outcome
- IncreaseTime to tolerance development
- Study
ratn: not reported in source
Morphine-induced tolerance and dependence in male Wistar rats- Outcome group
- Pain · Nervous system and cognition
- Studied dose
- 80 mg/kg · ipAs given in this study (rat).
Measurements
- Tolerance development
- 10 days
- 80 mg/kg
Source sentences
Results showed that administration of Cerebrolysin could prolonged development (10 and 14 days in administration of 80 mg/kg and 160 mg/kg Cerebrolysin) and completion (4, 10 and 14 days in administration of 40, 80 and 160 mg/kg Cerebrolysin, respectively) of tolerance.
2 context sentences(design, population, supporting numbers)
Male Wistar rats were selected randomly and divided into different groups (n=8) including: a control group, groups received additive doses of morphine (5-25 mg/kg, ip, at an interval of 12 h until tolerance completion), and groups pretreated with Cerebrolysin (40, 80 and 160 mg/kg, ip, before morphine administration).
Development of tolerance was assessed by tail-flick test and the attenuation effect of Cerebrolysin on morphine-induced dependence was evaluated after injection of naloxone (4 mg/kg, ip, 12 h after the morning dose of morphine).