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Study · Systematic review · 2018

4 results

Meta-analytic review of the effects of a single dose of intranasal oxytocin on threat processing in humans.

Leppanen J, Ng KW, Kim YR, Tchanturia K, Treasure J

Journal of affective disorders17 Aug 2017Cited by 40 (Europe PMC)

PMID28837950 (opens in a new tab)DOI10.1016/j.jad.2017.08.041 (opens in a new tab)PepBankPUB-28837950
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In healthy people, a single dose of intranasal oxytocin increased the physiological startle response to threat, with a small effect size.

    In plain wordsIn healthy people, one dose of intranasal oxytocin increased the body's startle response to a threat, with a small effect.

    Peptide
    Oxytocin
    Outcome
    IncreaseStartle response to threat
    Study

    n: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    single dose · intranasalAs given in this study (human).

    Source sentences

    Summary
    A single dose of intranasal oxytocin significantly increased the physiological startle response to threat in healthy people with a small effect size.
    2 context sentences
    Summary · context
    The review included 26 studies (N = 1173), nine of which included clinical populations (N = 234).
    Summary · context
    We examined the effects of a single dose of intranasal oxytocin on startle response, attentional responses, and behavioural responses to threat.
  2. 02HumanSystematic reviewEfficacy outcome

    A single dose of intranasal oxytocin had no significant effect on attentional bias towards social or disorder-specific threat.

    In plain wordsOne dose of intranasal oxytocin did not significantly change attention towards social or disorder-related threats.

    Peptide
    Oxytocin
    Outcome
    No significant changeAttentional bias towards social or disorder-specific threat
    Study

    n: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    single dose · intranasalAs given in this study (human).

    Source sentences

    Summary
    However, oxytocin did not have significant effects on attentional bias towards social or disorder-specific threat, fixation towards threatening stimuli among healthy or clinical populations, or on threat related behavioural approach or avoidance responses.
    2 context sentences
    Summary · context
    The review included 26 studies (N = 1173), nine of which included clinical populations (N = 234).
    Summary · context
    We examined the effects of a single dose of intranasal oxytocin on startle response, attentional responses, and behavioural responses to threat.
  3. 03HumanSystematic reviewEfficacy outcome

    In healthy and clinical populations, a single dose of intranasal oxytocin had no significant effect on fixation towards threatening stimuli.

    In plain wordsOne dose of intranasal oxytocin did not significantly change how long people looked at threatening images, in healthy or clinical groups.

    Peptide
    Oxytocin
    Outcome
    No significant changeFixation towards threatening stimuli
    Study

    n: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    single dose · intranasalAs given in this study (human).

    Source sentences

    Summary
    However, oxytocin did not have significant effects on attentional bias towards social or disorder-specific threat, fixation towards threatening stimuli among healthy or clinical populations, or on threat related behavioural approach or avoidance responses.
    2 context sentences
    Summary · context
    The review included 26 studies (N = 1173), nine of which included clinical populations (N = 234).
    Summary · context
    We examined the effects of a single dose of intranasal oxytocin on startle response, attentional responses, and behavioural responses to threat.
  4. 04HumanSystematic reviewEfficacy outcome

    A single dose of intranasal oxytocin had no significant effect on threat-related behavioural approach or avoidance responses.

    In plain wordsOne dose of intranasal oxytocin did not significantly change approach or avoidance behaviour towards threats.

    Peptide
    Oxytocin
    Outcome
    No significant changeThreat-related behavioural approach or avoidance
    Study

    n: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    single dose · intranasalAs given in this study (human).

    Source sentences

    Summary
    However, oxytocin did not have significant effects on attentional bias towards social or disorder-specific threat, fixation towards threatening stimuli among healthy or clinical populations, or on threat related behavioural approach or avoidance responses.
    2 context sentences
    Summary · context
    The review included 26 studies (N = 1173), nine of which included clinical populations (N = 234).
    Summary · context
    We examined the effects of a single dose of intranasal oxytocin on startle response, attentional responses, and behavioural responses to threat.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 stopped early · source ClinicalTrials.gov (opens in a new tab)

TerminatedPhase 1/2NCT03863288

Dose Response Relationship of Oxytocin on Irritability in Youths

University of Nebraskan = 6018 Feb 2022 to 27 Feb 2024

Irritable Mood

Trial pageClinicalTrials.govUpdated 14 Mar 2025

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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