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Study · Randomized controlled trial · 2018

6 results

Oxytocin Modulates Attention Switching Between Interoceptive Signals and External Social Cues.

Yao S, Becker B, Zhao W, Zhao Z, Kou J, Ma X, Geng Y, Ren P, Kendrick KM

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology27 Sept 2017Cited by 81 (Europe PMC)

PMID28836577 (opens in a new tab)PMCIDPMC5729568 (opens in a new tab)DOI10.1038/npp.2017.189 (opens in a new tab)PepBankPUB-28836577
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults receiving intranasal oxytocin or placebo, oxytocin did not change interoceptive accuracy during a heartbeat detection task alone compared with placebo.

    In plain wordsIn people doing a heartbeat task alone, intranasal oxytocin did not change how accurately they sensed their heartbeat compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeInteroceptive accuracy, Experiment 1
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    In Experiment 1, OT had no significant influence on interoceptive accuracy or associated activity in the right anterior insula (AI) and dorsal anterior cingulate cortex.
    1 context sentence
    Summary · context
    In a randomized, double-blind, between-subject, design study 83 subjects received either intranasal OT or placebo.
  2. 02HumanRandomized controlled trialMechanism

    In subjects performing a heartbeat detection task alone, intranasal oxytocin did not change activity in the right anterior insula or dorsal anterior cingulate cortex compared with placebo.

    In plain wordsIn people doing a heartbeat task alone, intranasal oxytocin did not change activity in two brain regions compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeRight anterior insula and dorsal anterior cingulate activity, Experiment 1
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    In Experiment 1, OT had no significant influence on interoceptive accuracy or associated activity in the right anterior insula (AI) and dorsal anterior cingulate cortex.
    1 context sentence
    Summary · context
    In a randomized, double-blind, between-subject, design study 83 subjects received either intranasal OT or placebo.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In subjects performing a heartbeat detection task while viewing faces, intranasal oxytocin decreased interoceptive accuracy compared with placebo.

    In plain wordsIn people sensing their heartbeat while viewing faces, intranasal oxytocin lowered heartbeat sensing accuracy compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseInteroceptive accuracy with face stimuli, Experiment 2
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    However, in Experiment 2 when face stimuli were also presented, OT decreased interoceptive accuracy and increased right AI activation and its functional connectivity with the left posterior insula (PI), with the latter both being negatively correlated with accuracy scores.
    1 context sentence
    Summary · context
    In a randomized, double-blind, between-subject, design study 83 subjects received either intranasal OT or placebo.
  4. 04HumanRandomized controlled trialMechanism

    In subjects viewing faces during a heartbeat detection task, intranasal oxytocin increased right anterior insula activation compared with placebo.

    In plain wordsIn people viewing faces during a heartbeat task, intranasal oxytocin increased activity in the right anterior insula compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseRight anterior insula activation with face stimuli, Experiment 2
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    However, in Experiment 2 when face stimuli were also presented, OT decreased interoceptive accuracy and increased right AI activation and its functional connectivity with the left posterior insula (PI), with the latter both being negatively correlated with accuracy scores.
    1 context sentence
    Summary · context
    In a randomized, double-blind, between-subject, design study 83 subjects received either intranasal OT or placebo.
  5. 05HumanRandomized controlled trialMechanism

    In subjects viewing faces during a heartbeat detection task, intranasal oxytocin increased functional connectivity between the right anterior insula and the left posterior insula compared with placebo.

    In plain wordsIn people viewing faces during a heartbeat task, intranasal oxytocin increased the link between two insula regions compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseRight anterior insula to left posterior insula connectivity, Experiment 2
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    However, in Experiment 2 when face stimuli were also presented, OT decreased interoceptive accuracy and increased right AI activation and its functional connectivity with the left posterior insula (PI), with the latter both being negatively correlated with accuracy scores.
    1 context sentence
    Summary · context
    In a randomized, double-blind, between-subject, design study 83 subjects received either intranasal OT or placebo.
  6. 06HumanRandomized controlled trialMechanism

    In subjects viewing faces during a heartbeat detection task, the oxytocin-related increases in right anterior insula activation and in its connectivity with the left posterior insula were negatively correlated with interoceptive accuracy scores.

    In plain wordsIn people viewing faces during a heartbeat task, the rise in activity in two insula regions went with lower heartbeat sensing accuracy.

    Peptide
    Oxytocin
    Outcome
    Not applicableCorrelation of right anterior insula activation and connectivity with interoceptive accuracy, Experiment 2
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    with the latter both being negatively correlated with accuracy scores
    1 context sentence
    Summary · context
    In a randomized, double-blind, between-subject, design study 83 subjects received either intranasal OT or placebo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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