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Study · Animal study (in vivo) · minipigs · 2015

11 results

Pharmacological inhibition of the triggering receptor expressed on myeloid cells-1 limits reperfusion injury in a porcine model of myocardial infarction.

Lemarié J, Boufenzer A, Popovic B, Tran N, Groubatch F, Derive M, Labroca P, Barraud D, Gibot S

ESC heart failure1 Jun 2015Cited by 24 (Europe PMC)

PMID28834656 (opens in a new tab)PMCIDPMC6410538 (opens in a new tab)DOI10.1002/ehf2.12029 (opens in a new tab)PepBankPUB-28834656
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with myocardial infarction, LR12 improved reduced mean arterial pressure versus vehicle.

    In plain wordsIn minipigs with heart infarction, LR12 improved reduced mean arterial pressure versus vehicle.

    Peptide
    Nangibotide
    Outcome
    IncreaseMean arterial pressure
    Study

    minipigsn = 15

    coronary artery occlusion-reperfusion myocardial infarction
    Comparator
    Vehicle
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    TREM-1 inhibition by LR12 significantly improved these dysfunctions (P < 0.03) and limited infarct size, as assessed by lower creatine phosphokinase and troponin I concentrations (P < 0.005).
    3 context sentences
    Summary · context
    AMI altered hemodynamics and cardiac function, as illustrated by a drop of mean arterial pressure, cardiac index, cardiac power index, ejection fraction, and real-time pressure-volume loop-derived parameters.
    Summary · context
    AMI was induced in 15 adult minipigs by a closed-chest coronary artery occlusion-reperfusion technique.
    Summary · context
    Animals were randomized to receive LR12 or vehicle before reperfusion (LR12 n = 7, vehicle n = 8), and were monitored during 18 h.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with myocardial infarction, LR12 improved reduced cardiac index versus vehicle.

    In plain wordsIn minipigs with heart infarction, LR12 improved reduced cardiac index versus vehicle.

    Peptide
    Nangibotide
    Outcome
    IncreaseCardiac index
    Study

    minipigsn = 15

    coronary artery occlusion-reperfusion myocardial infarction
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    TREM-1 inhibition by LR12 significantly improved these dysfunctions (P < 0.03) and limited infarct size, as assessed by lower creatine phosphokinase and troponin I concentrations (P < 0.005).
    3 context sentences
    Summary · context
    AMI altered hemodynamics and cardiac function, as illustrated by a drop of mean arterial pressure, cardiac index, cardiac power index, ejection fraction, and real-time pressure-volume loop-derived parameters.
    Summary · context
    AMI was induced in 15 adult minipigs by a closed-chest coronary artery occlusion-reperfusion technique.
    Summary · context
    Animals were randomized to receive LR12 or vehicle before reperfusion (LR12 n = 7, vehicle n = 8), and were monitored during 18 h.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with myocardial infarction, LR12 improved reduced cardiac power index versus vehicle.

    In plain wordsIn minipigs with heart infarction, LR12 improved reduced cardiac power index versus vehicle.

    Peptide
    Nangibotide
    Outcome
    IncreaseCardiac power index
    Study

    minipigsn = 15

    coronary artery occlusion-reperfusion myocardial infarction
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    TREM-1 inhibition by LR12 significantly improved these dysfunctions (P < 0.03) and limited infarct size, as assessed by lower creatine phosphokinase and troponin I concentrations (P < 0.005).
    3 context sentences
    Summary · context
    AMI altered hemodynamics and cardiac function, as illustrated by a drop of mean arterial pressure, cardiac index, cardiac power index, ejection fraction, and real-time pressure-volume loop-derived parameters.
    Summary · context
    AMI was induced in 15 adult minipigs by a closed-chest coronary artery occlusion-reperfusion technique.
    Summary · context
    Animals were randomized to receive LR12 or vehicle before reperfusion (LR12 n = 7, vehicle n = 8), and were monitored during 18 h.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with myocardial infarction, LR12 improved reduced ejection fraction versus vehicle.

    In plain wordsIn minipigs with heart infarction, LR12 improved reduced ejection fraction versus vehicle.

    Peptide
    Nangibotide
    Outcome
    IncreaseEjection fraction
    Study

    minipigsn = 15

    coronary artery occlusion-reperfusion myocardial infarction
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    TREM-1 inhibition by LR12 significantly improved these dysfunctions (P < 0.03) and limited infarct size, as assessed by lower creatine phosphokinase and troponin I concentrations (P < 0.005).
    3 context sentences
    Summary · context
    AMI altered hemodynamics and cardiac function, as illustrated by a drop of mean arterial pressure, cardiac index, cardiac power index, ejection fraction, and real-time pressure-volume loop-derived parameters.
    Summary · context
    AMI was induced in 15 adult minipigs by a closed-chest coronary artery occlusion-reperfusion technique.
    Summary · context
    Animals were randomized to receive LR12 or vehicle before reperfusion (LR12 n = 7, vehicle n = 8), and were monitored during 18 h.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with myocardial infarction, LR12 improved reduced pressure-volume loop-derived parameters versus vehicle.

    In plain wordsIn minipigs with heart infarction, LR12 improved pressure-volume measures versus vehicle.

    Peptide
    Nangibotide
    Outcome
    IncreasePressure-volume loop-derived parameters
    Study

    minipigsn = 15

    coronary artery occlusion-reperfusion myocardial infarction
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    TREM-1 inhibition by LR12 significantly improved these dysfunctions (P < 0.03) and limited infarct size, as assessed by lower creatine phosphokinase and troponin I concentrations (P < 0.005).
    3 context sentences
    Summary · context
    AMI altered hemodynamics and cardiac function, as illustrated by a drop of mean arterial pressure, cardiac index, cardiac power index, ejection fraction, and real-time pressure-volume loop-derived parameters.
    Summary · context
    AMI was induced in 15 adult minipigs by a closed-chest coronary artery occlusion-reperfusion technique.
    Summary · context
    Animals were randomized to receive LR12 or vehicle before reperfusion (LR12 n = 7, vehicle n = 8), and were monitored during 18 h.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with myocardial infarction, LR12 limited infarct size versus vehicle.

    In plain wordsIn minipigs with heart infarction, LR12 limited infarct size versus vehicle.

    Peptide
    Nangibotide
    Outcome
    DecreaseInfarct size
    Study

    minipigsn = 15

    coronary artery occlusion-reperfusion myocardial infarction
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    TREM-1 inhibition by LR12 significantly improved these dysfunctions (P < 0.03) and limited infarct size, as assessed by lower creatine phosphokinase and troponin I concentrations (P < 0.005).
    2 context sentences
    Summary · context
    AMI was induced in 15 adult minipigs by a closed-chest coronary artery occlusion-reperfusion technique.
    Summary · context
    Animals were randomized to receive LR12 or vehicle before reperfusion (LR12 n = 7, vehicle n = 8), and were monitored during 18 h.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with myocardial infarction, LR12 lowered creatine phosphokinase concentration versus vehicle.

    In plain wordsIn minipigs with heart infarction, LR12 lowered creatine phosphokinase concentration versus vehicle.

    Peptide
    Nangibotide
    Outcome
    DecreaseCreatine phosphokinase concentration
    Study

    minipigsn = 15

    coronary artery occlusion-reperfusion myocardial infarction
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    TREM-1 inhibition by LR12 significantly improved these dysfunctions (P < 0.03) and limited infarct size, as assessed by lower creatine phosphokinase and troponin I concentrations (P < 0.005).
    2 context sentences
    Summary · context
    AMI was induced in 15 adult minipigs by a closed-chest coronary artery occlusion-reperfusion technique.
    Summary · context
    Animals were randomized to receive LR12 or vehicle before reperfusion (LR12 n = 7, vehicle n = 8), and were monitored during 18 h.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with myocardial infarction, LR12 lowered troponin I concentration versus vehicle.

    In plain wordsIn minipigs with heart infarction, LR12 lowered troponin I concentration versus vehicle.

    Peptide
    Nangibotide
    Outcome
    DecreaseTroponin I concentration
    Study

    minipigsn = 15

    coronary artery occlusion-reperfusion myocardial infarction
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    TREM-1 inhibition by LR12 significantly improved these dysfunctions (P < 0.03) and limited infarct size, as assessed by lower creatine phosphokinase and troponin I concentrations (P < 0.005).
    2 context sentences
    Summary · context
    AMI was induced in 15 adult minipigs by a closed-chest coronary artery occlusion-reperfusion technique.
    Summary · context
    Animals were randomized to receive LR12 or vehicle before reperfusion (LR12 n = 7, vehicle n = 8), and were monitored during 18 h.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with myocardial infarction, LR12 improved the PaO2 to FiO2 ratio versus vehicle.

    In plain wordsIn minipigs with heart infarction, LR12 improved the blood oxygen ratio versus vehicle.

    Peptide
    Nangibotide
    Outcome
    IncreasePaO2 to FiO2 ratio
    Study

    minipigsn = 15

    coronary artery occlusion-reperfusion myocardial infarction
    Comparator
    Vehicle
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pulmonary, renal, and hepatic impairments occurred after AMI and were attenuated by LR12 administration as assessed by a better PaO2 to FiO2 ratio, a less positive fluid balance, and lower liver enzymes levels (P < 0.05).
    2 context sentences
    Summary · context
    AMI was induced in 15 adult minipigs by a closed-chest coronary artery occlusion-reperfusion technique.
    Summary · context
    Animals were randomized to receive LR12 or vehicle before reperfusion (LR12 n = 7, vehicle n = 8), and were monitored during 18 h.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with myocardial infarction, LR12 produced a less positive fluid balance versus vehicle.

    In plain wordsIn minipigs with heart infarction, LR12 produced a less positive fluid balance versus vehicle.

    Peptide
    Nangibotide
    Outcome
    DecreaseFluid balance
    Study

    minipigsn = 15

    coronary artery occlusion-reperfusion myocardial infarction
    Comparator
    Vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pulmonary, renal, and hepatic impairments occurred after AMI and were attenuated by LR12 administration as assessed by a better PaO2 to FiO2 ratio, a less positive fluid balance, and lower liver enzymes levels (P < 0.05).
    2 context sentences
    Summary · context
    AMI was induced in 15 adult minipigs by a closed-chest coronary artery occlusion-reperfusion technique.
    Summary · context
    Animals were randomized to receive LR12 or vehicle before reperfusion (LR12 n = 7, vehicle n = 8), and were monitored during 18 h.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In minipigs with myocardial infarction, LR12 lowered liver enzyme levels versus vehicle.

    In plain wordsIn minipigs with heart infarction, LR12 lowered liver enzyme levels versus vehicle.

    Peptide
    Nangibotide
    Outcome
    DecreaseLiver enzyme levels
    Study

    minipigsn = 15

    coronary artery occlusion-reperfusion myocardial infarction
    Comparator
    Vehicle
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pulmonary, renal, and hepatic impairments occurred after AMI and were attenuated by LR12 administration as assessed by a better PaO2 to FiO2 ratio, a less positive fluid balance, and lower liver enzymes levels (P < 0.05).
    2 context sentences
    Summary · context
    AMI was induced in 15 adult minipigs by a closed-chest coronary artery occlusion-reperfusion technique.
    Summary · context
    Animals were randomized to receive LR12 or vehicle before reperfusion (LR12 n = 7, vehicle n = 8), and were monitored during 18 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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