Short-Term Teriparatide and Recombinant Human Bone Morphogenetic Protein-2 for Regenerative Approach to Medication-Related Osteonecrosis of the Jaw: A Preliminary Study.

Jung J, Yoo HY, Kim GT, Lee JW, Lee YA, Kim DY, Kwon YD

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research18 Sept 2017Cited by 45 (Europe PMC)

PMID28815779DOI10.1002/jbmr.3237PepBankPUB-28815779

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. 2 results from people.

01HumanNon-randomized trialEfficacy outcome
In patients with jaw osteonecrosis, adding teriparatide to rhBMP-2 increased the bone regeneration ratio versus rhBMP-2 alone.
In plain wordsIn patients with jaw osteonecrosis, adding teriparatide to rhBMP-2 increased the bone regeneration ratio versus rhBMP-2 alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone regeneration ratio versus rhBMP-2
Study
n: not reported in source
Comparator
rhBMP-2 alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
The regeneration ratio was significantly greater in the group PTH+BMP than in the BMP and control groups.
3 context sentences(design, population, supporting numbers)
Summary · context
This study enrolled 17 patients diagnosed with MRONJ.
Summary · context
All patients received sequestrectomy under general or local anesthesia with suspension of bisphosphonate.
Summary · context
The patients were divided into groups, based on their treatment regimens: teriparatide combined with rhBMP-2 (parathyroid hormone [PTH]+BMP), rhBMP-2 (BMP), and the control.
Report a problemFND-2881577903
02HumanNon-randomized trialEfficacy outcome
In patients with jaw osteonecrosis, adding teriparatide to rhBMP-2 increased the amount of bone formation versus rhBMP-2 alone.
In plain wordsIn patients with jaw osteonecrosis, adding teriparatide to rhBMP-2 increased the amount of bone formation versus rhBMP-2 alone.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseAmount of bone formation versus rhBMP-2
Study
n: not reported in source
Comparator
rhBMP-2 alone
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Significantly greater amount of bone formation was observed in the group PTH+BMP than in the BMP and control groups.
3 context sentences(design, population, supporting numbers)
Summary · context
This study enrolled 17 patients diagnosed with MRONJ.
Summary · context
All patients received sequestrectomy under general or local anesthesia with suspension of bisphosphonate.
Summary · context
The patients were divided into groups, based on their treatment regimens: teriparatide combined with rhBMP-2 (parathyroid hormone [PTH]+BMP), rhBMP-2 (BMP), and the control.
Report a problemFND-2881577905

Studies that did not test the peptide alone4

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

03HumanNot a test of Teriparatide (PTH 1-34) aloneNon-randomized trialEfficacy outcome
In patients with jaw osteonecrosis, serum osteocalcin increased after surgery in the teriparatide plus rhBMP-2 group.
In plain wordsIn patients with jaw osteonecrosis, serum osteocalcin increased after surgery with combined teriparatide and rhBMP-2.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSerum osteocalcin
Study
n: not reported in source
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Significant increase was observed in the values of the biochemical markers, serum osteocalcin, and serum C-terminal telopeptide cross-link of type I collagen, within 3 months of surgery in the PTH+BMP group, whereas the mean value in the BMP group did not show a significant change.
3 context sentences(design, population, supporting numbers)
Summary · context
This study enrolled 17 patients diagnosed with MRONJ.
Summary · context
All patients received sequestrectomy under general or local anesthesia with suspension of bisphosphonate.
Summary · context
The patients were divided into groups, based on their treatment regimens: teriparatide combined with rhBMP-2 (parathyroid hormone [PTH]+BMP), rhBMP-2 (BMP), and the control.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-2881577901
04HumanNot a test of Teriparatide (PTH 1-34) aloneNon-randomized trialEfficacy outcome
In patients with jaw osteonecrosis, serum C-terminal telopeptide increased after surgery in the teriparatide plus rhBMP-2 group.
In plain wordsIn patients with jaw osteonecrosis, a bone turnover marker increased after surgery with combined teriparatide and rhBMP-2.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseSerum C-terminal telopeptide
Study
n: not reported in source
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Significant increase was observed in the values of the biochemical markers, serum osteocalcin, and serum C-terminal telopeptide cross-link of type I collagen, within 3 months of surgery in the PTH+BMP group, whereas the mean value in the BMP group did not show a significant change.
3 context sentences(design, population, supporting numbers)
Summary · context
This study enrolled 17 patients diagnosed with MRONJ.
Summary · context
All patients received sequestrectomy under general or local anesthesia with suspension of bisphosphonate.
Summary · context
The patients were divided into groups, based on their treatment regimens: teriparatide combined with rhBMP-2 (parathyroid hormone [PTH]+BMP), rhBMP-2 (BMP), and the control.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-2881577902
05HumanNot a test of Teriparatide (PTH 1-34) aloneNon-randomized trialEfficacy outcome
In patients with jaw osteonecrosis, combined teriparatide and rhBMP-2 increased the bone regeneration ratio versus control.
In plain wordsIn patients with jaw osteonecrosis, combined teriparatide and rhBMP-2 increased the bone regeneration ratio versus control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone regeneration ratio versus control
Study
n: not reported in source
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
The regeneration ratio was significantly greater in the group PTH+BMP than in the BMP and control groups.
3 context sentences(design, population, supporting numbers)
Summary · context
This study enrolled 17 patients diagnosed with MRONJ.
Summary · context
All patients received sequestrectomy under general or local anesthesia with suspension of bisphosphonate.
Summary · context
The patients were divided into groups, based on their treatment regimens: teriparatide combined with rhBMP-2 (parathyroid hormone [PTH]+BMP), rhBMP-2 (BMP), and the control.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-2881577904
06HumanNot a test of Teriparatide (PTH 1-34) aloneNon-randomized trialEfficacy outcome
In patients with jaw osteonecrosis, combined teriparatide and rhBMP-2 increased the amount of bone formation versus control.
In plain wordsIn patients with jaw osteonecrosis, combined teriparatide and rhBMP-2 increased the amount of bone formation versus control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseAmount of bone formation versus control
Study
n: not reported in source
Comparator
Control
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Significantly greater amount of bone formation was observed in the group PTH+BMP than in the BMP and control groups.
3 context sentences(design, population, supporting numbers)
Summary · context
This study enrolled 17 patients diagnosed with MRONJ.
Summary · context
All patients received sequestrectomy under general or local anesthesia with suspension of bisphosphonate.
Summary · context
The patients were divided into groups, based on their treatment regimens: teriparatide combined with rhBMP-2 (parathyroid hormone [PTH]+BMP), rhBMP-2 (BMP), and the control.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-2881577906

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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