Skip to content

Study · Randomized controlled trial · n = 38 · 2017

4 results

Intranasal Oxytocin Selectively Modulates Large-Scale Brain Networks in Humans.

Brodmann K, Gruber O, Goya-Maldonado R

Brain connectivity1 Sept 2017Cited by 32 (Europe PMC)

PMID28762756 (opens in a new tab)PMCIDPMC5647506 (opens in a new tab)DOI10.1089/brain.2017.0528 (opens in a new tab)PepBankPUB-28762756
Source linkPubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In healthy men, intranasal oxytocin reduced coupling of the ventral attention network to regions that form the default mode network nodes, versus placebo.

    In plain wordsIn healthy men, oxytocin lowered the link between an attention network and a self-reflection network in brain scans, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseVentral attention network coupling with default mode network regions
    Study

    n = 38

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Our results show that OT mainly alters connectivity in the VA, on one side reducing the coupling to regions that typically form the nodes of DM, an introspective and self-referential network, and on the other side increasing the coupling to the edges of the CO, which is involved in salience processing.
    1 context sentence
    Summary · context
    Therefore, we conducted a placebo-controlled crossover study with intranasal 24 IU OT in 38 healthy male subjects using a resting-state functional magnetic resonance imaging paradigm to investigate its impact over these three networks candidates.
  2. 02HumanRandomized controlled trialMechanism

    In healthy men, intranasal oxytocin increased coupling of the ventral attention network to the edges of the cingulo-opercular network, versus placebo.

    In plain wordsIn healthy men, oxytocin raised the link between an attention network and a salience network in brain scans, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseVentral attention network coupling with cingulo-opercular network edges
    Study

    n = 38

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Our results show that OT mainly alters connectivity in the VA, on one side reducing the coupling to regions that typically form the nodes of DM, an introspective and self-referential network, and on the other side increasing the coupling to the edges of the CO, which is involved in salience processing.
    1 context sentence
    Summary · context
    Therefore, we conducted a placebo-controlled crossover study with intranasal 24 IU OT in 38 healthy male subjects using a resting-state functional magnetic resonance imaging paradigm to investigate its impact over these three networks candidates.
  3. 03HumanRandomized controlled trialMechanism

    In healthy men, oxytocin-related network changes correlated significantly with erroneous performance during decision-making.

    In plain wordsIn healthy men, brain network changes after oxytocin were linked to errors in a decision task.

    Peptide
    Oxytocin
    Outcome
    Not applicableCorrelation of network changes with erroneous decision-making performance
    Study

    n = 38

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Indeed, we observed significant correlations with the erroneous performance during decision-making but not with the obtained impulsivity scores.
    1 context sentence
    Summary · context
    Therefore, we conducted a placebo-controlled crossover study with intranasal 24 IU OT in 38 healthy male subjects using a resting-state functional magnetic resonance imaging paradigm to investigate its impact over these three networks candidates.
  4. 04HumanRandomized controlled trialMechanism

    In healthy men, oxytocin-related network changes did not correlate significantly with impulsivity scores.

    In plain wordsIn healthy men, brain network changes after oxytocin were not linked to impulsivity scores.

    Peptide
    Oxytocin
    Outcome
    No significant changeCorrelation of network changes with impulsivity scores
    Study

    n = 38

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Indeed, we observed significant correlations with the erroneous performance during decision-making but not with the obtained impulsivity scores.
    1 context sentence
    Summary · context
    Therefore, we conducted a placebo-controlled crossover study with intranasal 24 IU OT in 38 healthy male subjects using a resting-state functional magnetic resonance imaging paradigm to investigate its impact over these three networks candidates.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.