Nephroprotective Effect of EDL Peptide at Acute Injury of Kidneys of Different Genesis.

Zamorskii II, Shchudrova TS, Lin'kova NS, Nichik TE, Khavinson VK

Bulletin of experimental biology and medicine25 Jul 2017Cited by 4 (Europe PMC)

PMID28744634DOI10.1007/s10517-017-3811-1PepBankPUB-28744634

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with experimental kidney injury, EDL prevented oliguria.
In plain wordsIn rats with experimental kidney injury, EDL prevented low urine output.
Peptide
Ovagen (EDL)
Outcome
DecreaseOliguria
Study
ratn: not reported in source
gentamycin-induced nephropathy and ischemia/reperfusion kidney injury
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The nephroprotective effect of EDL peptide manifested in prevention of oliguria and retention azotemia
1 context sentence(design, population, supporting numbers)
Summary · context
EDL peptide produced a nephroprotective effect on experimental models gentamycin-induced nephropathy and ischemia/reperfusion kidney injury in rats.
Report a problemFND-2874463401
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with experimental kidney injury, EDL prevented retention azotemia.
In plain wordsIn rats with experimental kidney injury, EDL prevented the buildup of nitrogen-containing waste in blood.
Peptide
Ovagen (EDL)
Outcome
DecreaseRetention azotemia
Study
ratn: not reported in source
gentamycin-induced nephropathy and ischemia/reperfusion kidney injury
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
The nephroprotective effect of EDL peptide manifested in prevention of oliguria and retention azotemia
1 context sentence(design, population, supporting numbers)
Summary · context
EDL peptide produced a nephroprotective effect on experimental models gentamycin-induced nephropathy and ischemia/reperfusion kidney injury in rats.
Report a problemFND-2874463402
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with experimental kidney injury, EDL decreased proteinuria.
In plain wordsIn rats with experimental kidney injury, EDL reduced protein in urine.
Peptide
Ovagen (EDL)
Outcome
DecreaseProteinuria
Study
ratn: not reported in source
gentamycin-induced nephropathy and ischemia/reperfusion kidney injury
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
a decrease in proteinuria and sodium excretion
1 context sentence(design, population, supporting numbers)
Summary · context
EDL peptide produced a nephroprotective effect on experimental models gentamycin-induced nephropathy and ischemia/reperfusion kidney injury in rats.
Report a problemFND-2874463403
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with experimental kidney injury, EDL decreased sodium excretion.
In plain wordsIn rats with experimental kidney injury, EDL reduced sodium excretion.
Peptide
Ovagen (EDL)
Outcome
DecreaseSodium excretion
Study
ratn: not reported in source
gentamycin-induced nephropathy and ischemia/reperfusion kidney injury
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
a decrease in proteinuria and sodium excretion
1 context sentence(design, population, supporting numbers)
Summary · context
EDL peptide produced a nephroprotective effect on experimental models gentamycin-induced nephropathy and ischemia/reperfusion kidney injury in rats.
Report a problemFND-2874463404
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with experimental kidney injury, EDL prevented a critical decrease in antioxidant enzyme activities.
In plain wordsIn rats with experimental kidney injury, EDL prevented a critical decrease in antioxidant enzyme activities.
Peptide
Ovagen (EDL)
Outcome
IncreaseAntioxidant enzyme activities
Study
ratn: not reported in source
gentamycin-induced nephropathy and ischemia/reperfusion kidney injury
Outcome group
Oxidative stress · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
prevention of critical decrease in activities of antioxidant enzymes
1 context sentence(design, population, supporting numbers)
Summary · context
EDL peptide produced a nephroprotective effect on experimental models gentamycin-induced nephropathy and ischemia/reperfusion kidney injury in rats.
Report a problemFND-2874463405
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with experimental kidney injury, EDL suppressed lipid peroxidation.
In plain wordsIn rats with experimental kidney injury, EDL reduced lipid peroxidation.
Peptide
Ovagen (EDL)
Outcome
DecreaseLipid peroxidation
Study
ratn: not reported in source
gentamycin-induced nephropathy and ischemia/reperfusion kidney injury
Outcome group
Oxidative stress · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
suppression of LPO, and normalization of energy supply to kidneys cells.
1 context sentence(design, population, supporting numbers)
Summary · context
EDL peptide produced a nephroprotective effect on experimental models gentamycin-induced nephropathy and ischemia/reperfusion kidney injury in rats.
Report a problemFND-2874463406
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with experimental kidney injury, EDL normalized energy supply to kidney cells.
In plain wordsIn rats with experimental kidney injury, EDL normalized the energy supply to kidney cells.
Peptide
Ovagen (EDL)
Outcome
Direction not reportedKidney cell energy supply
Study
ratn: not reported in source
gentamycin-induced nephropathy and ischemia/reperfusion kidney injury
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
normalization of energy supply to kidneys cells.
1 context sentence(design, population, supporting numbers)
Summary · context
EDL peptide produced a nephroprotective effect on experimental models gentamycin-induced nephropathy and ischemia/reperfusion kidney injury in rats.
Report a problemFND-2874463407

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 17:05 UTC
Study results updated
Version 1
21 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

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MeSH terms

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