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Study · Non-randomized trial · n = 10 · 2017

2 results

Oxytocin effects on emotional response to others' faces via serotonin system in autism: A pilot study.

Fukai M, Hirosawa T, Kikuchi M, Ouchi Y, Takahashi T, Yoshimura Y, Miyagishi Y, Kosaka H, Yokokura M, Yoshikawa E, Bunai T, Minabe Y

Psychiatry research. Neuroimaging28 Jun 2017Cited by 12 (Europe PMC)

PMID28738293 (opens in a new tab)DOI10.1016/j.pscychresns.2017.06.015 (opens in a new tab)PepBankPUB-28738293
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In men with autism spectrum disorder, 8-10 weeks of oxytocin did not significantly change the emotional response to others' faces.

    In plain wordsIn men with autism, 8-10 weeks of oxytocin did not clearly change emotional responses to other people's faces.

    Peptide
    Oxytocin
    Outcome
    No significant changeEmotional response to others' faces
    Study

    n = 10

    Analysis
    Primary
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · 8-10 weeksAs given in this study (human).

    Source sentences

    Summary
    No significant change was found in the emotional response to others' faces after the 8-10 week OT treatment.
    1 context sentence
    Summary · context
    Ten male subjects with ASD were administered OT for 8-10 weeks in an open-label, single-arm, non-randomized, uncontrolled manner.
  2. 02HumanNon-randomized trialMechanism

    In men with autism spectrum disorder given oxytocin, the increase in striatal serotonin transporter level after treatment correlated significantly with an increased negative emotional response to human faces.

    In plain wordsIn men with autism given oxytocin, a rise in a brain serotonin protein was linked to a stronger negative response to faces.

    Peptide
    Oxytocin
    Outcome
    Not applicableCorrelation of striatal SERT increase with negative emotional response to faces
    Study

    n = 10

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · 8-10 weeksAs given in this study (human).

    Source sentences

    Summary
    However, the increased serotonin transporter (SERT) level in the striatum after treatment was correlated significantly with increased negative emotional response to human faces.
    1 context sentence
    Summary · context
    Ten male subjects with ASD were administered OT for 8-10 weeks in an open-label, single-arm, non-randomized, uncontrolled manner.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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