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Study · Not a test of the peptide alone · 2017

10 results

Total and free cortisol levels during 1 μg, 25 μg, and 250 μg cosyntropin stimulation tests compared to insulin tolerance test: results of a randomized, prospective, pilot study.

Peechakara S, Bena J, Clarke NJ, McPhaul MJ, Reitz RE, Weil RJ, Recinos P, Kennedy L, Hamrahian AH

Endocrine20 Jul 2017Cited by 7 (Europe PMC)

PMID28730418 (opens in a new tab)DOI10.1007/s12020-017-1371-9 (opens in a new tab)PepBankPUB-28730418
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone10

In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cosyntropin.

  1. 01HumanNot a test of Cosyntropin aloneRandomized controlled trialOther

    In patients with pituitary disease and controls, the low-dose cosyntropin cutoff was 14.6 μg/dL with 100% sensitivity and specificity.

    In plain wordsThe low-dose cosyntropin cutoff was 14.6 μg/dL with 100% sensitivity and specificity versus the insulin tolerance test.

    Peptide
    Cosyntropin
    Outcome
    Not applicableLow-dose total cortisol cutoff
    Study

    n: not reported in source

    Comparator
    Insulin tolerance test
    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Measurements

    Cutoff
    14.6 μg/dL
    low dose
    Sensitivity
    100%
    low dose
    Specificity
    100%
    low dose

    Source sentences

    Summary
    The best total cortisol cut-off during low dose cosyntropin test, medium dose cosyntropin test, 30 min and 60 min standard dose cosyntropin test were 14.6 μg/dL (100% sensitivity & specificity), 18.7 μg/dL (100% sensitivity, 88% specificity), 16.1 (100% sensitivity & specificity), and 19.5 μg/dL (10…
    4 context sentences
    Summary · context
    We conducted a prospective, randomized pilot study to compare 1 μg IV low dose cosyntropin test, 25 μg IM medium dose cosyntropin test, and 250 μg IM standard dose cosyntropin test to evaluate secondary adrenal insufficiency.
    Summary · context
    Insulin tolerance test was used as the gold standard.
    Summary · context
    The study included patients with hypothalamic/pituitary disease (n  = 10) with at least one pituitary axis deficiency other than ACTH deficiency and controls (n  = 12).
    Summary · context
    All tests were done in random order.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  2. 02HumanNot a test of Cosyntropin aloneRandomized controlled trialOther

    In patients with pituitary disease and controls, the medium-dose cosyntropin cutoff was 18.7 μg/dL with 100% sensitivity and 88% specificity.

    In plain wordsThe medium-dose cosyntropin cutoff was 18.7 μg/dL with 100% sensitivity and 88% specificity versus the insulin tolerance test.

    Peptide
    Cosyntropin
    Outcome
    Not applicableMedium-dose total cortisol cutoff
    Study

    n: not reported in source

    Comparator
    Insulin tolerance test
    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Measurements

    Cutoff
    18.7 μg/dL
    medium dose
    Sensitivity
    100%
    medium dose
    Specificity
    88%
    medium dose

    Source sentences

    Summary
    The best total cortisol cut-off during low dose cosyntropin test, medium dose cosyntropin test, 30 min and 60 min standard dose cosyntropin test were 14.6 μg/dL (100% sensitivity & specificity), 18.7 μg/dL (100% sensitivity, 88% specificity), 16.1 (100% sensitivity & specificity), and 19.5 μg/dL (10…
    4 context sentences
    Summary · context
    We conducted a prospective, randomized pilot study to compare 1 μg IV low dose cosyntropin test, 25 μg IM medium dose cosyntropin test, and 250 μg IM standard dose cosyntropin test to evaluate secondary adrenal insufficiency.
    Summary · context
    Insulin tolerance test was used as the gold standard.
    Summary · context
    The study included patients with hypothalamic/pituitary disease (n  = 10) with at least one pituitary axis deficiency other than ACTH deficiency and controls (n  = 12).
    Summary · context
    All tests were done in random order.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  3. 03HumanNot a test of Cosyntropin aloneRandomized controlled trialOther

    In patients with pituitary disease and controls, the standard-dose cutoff at 30 minutes was 16.1 with 100% sensitivity and specificity.

    In plain wordsAt 30 minutes, the standard-dose cutoff was 16.1 with 100% sensitivity and specificity versus the insulin tolerance test.

    Peptide
    Cosyntropin
    Outcome
    Not applicableStandard-dose total cortisol cutoff at 30 minutes
    Study

    n: not reported in source

    Comparator
    Insulin tolerance test
    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Measurements

    Cutoff
    16.1
    standard dose, 30 minutes
    Sensitivity
    100%
    standard dose, 30 minutes
    Specificity
    100%
    standard dose, 30 minutes

    Source sentences

    Summary
    The best total cortisol cut-off during low dose cosyntropin test, medium dose cosyntropin test, 30 min and 60 min standard dose cosyntropin test were 14.6 μg/dL (100% sensitivity & specificity), 18.7 μg/dL (100% sensitivity, 88% specificity), 16.1 (100% sensitivity & specificity), and 19.5 μg/dL (10…
    4 context sentences
    Summary · context
    We conducted a prospective, randomized pilot study to compare 1 μg IV low dose cosyntropin test, 25 μg IM medium dose cosyntropin test, and 250 μg IM standard dose cosyntropin test to evaluate secondary adrenal insufficiency.
    Summary · context
    Insulin tolerance test was used as the gold standard.
    Summary · context
    The study included patients with hypothalamic/pituitary disease (n  = 10) with at least one pituitary axis deficiency other than ACTH deficiency and controls (n  = 12).
    Summary · context
    All tests were done in random order.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  4. 04HumanNot a test of Cosyntropin aloneRandomized controlled trialOther

    In patients with pituitary disease and controls, the standard-dose cutoff at 60 minutes was 19.5 μg/dL with 100% sensitivity and specificity.

    In plain wordsAt 60 minutes, the standard-dose cutoff was 19.5 μg/dL with 100% sensitivity and specificity versus the insulin tolerance test.

    Peptide
    Cosyntropin
    Outcome
    Not applicableStandard-dose total cortisol cutoff at 60 minutes
    Study

    n: not reported in source

    Comparator
    Insulin tolerance test
    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Measurements

    Cutoff
    19.5 μg/dL
    standard dose, 60 minutes
    Sensitivity
    100%
    standard dose, 60 minutes
    Specificity
    100%
    standard dose, 60 minutes

    Source sentences

    Summary
    The best total cortisol cut-off during low dose cosyntropin test, medium dose cosyntropin test, 30 min and 60 min standard dose cosyntropin test were 14.6 μg/dL (100% sensitivity & specificity), 18.7 μg/dL (100% sensitivity, 88% specificity), 16.1 (100% sensitivity & specificity), and 19.5 μg/dL (10…
    4 context sentences
    Summary · context
    We conducted a prospective, randomized pilot study to compare 1 μg IV low dose cosyntropin test, 25 μg IM medium dose cosyntropin test, and 250 μg IM standard dose cosyntropin test to evaluate secondary adrenal insufficiency.
    Summary · context
    Insulin tolerance test was used as the gold standard.
    Summary · context
    The study included patients with hypothalamic/pituitary disease (n  = 10) with at least one pituitary axis deficiency other than ACTH deficiency and controls (n  = 12).
    Summary · context
    All tests were done in random order.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  5. 05HumanNot a test of Cosyntropin aloneRandomized controlled trialOther

    In patients with pituitary disease and controls, cortisol ROC curves did not differ between cosyntropin tests (p > 0.41).

    In plain wordsCortisol ROC curves did not differ between cosyntropin tests in patients with pituitary disease and controls.

    Peptide
    Cosyntropin
    Outcome
    No significant changeCortisol ROC curves
    Study

    n: not reported in source

    Comparator
    Other cosyntropin stimulation tests
    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Measurements

    P
    > 0.41
    ROC curve comparison between cosyntropin tests

    Source sentences

    Summary
    There was no difference in the ROC curve for cortisol values between the cosyntropin stimulation tests (p  > 0.41).
    4 context sentences
    Summary · context
    We conducted a prospective, randomized pilot study to compare 1 μg IV low dose cosyntropin test, 25 μg IM medium dose cosyntropin test, and 250 μg IM standard dose cosyntropin test to evaluate secondary adrenal insufficiency.
    Summary · context
    Insulin tolerance test was used as the gold standard.
    Summary · context
    The study included patients with hypothalamic/pituitary disease (n  = 10) with at least one pituitary axis deficiency other than ACTH deficiency and controls (n  = 12).
    Summary · context
    All tests were done in random order.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  6. 06HumanNot a test of Cosyntropin aloneRandomized controlled trialOther

    At a cutoff of 18 μg/dL, only standard-dose cosyntropin cortisol at 30 minutes discriminated similarly to the insulin tolerance test.

    In plain wordsAt an 18 μg/dL cutoff, only the standard-dose test at 30 minutes discriminated similarly to the insulin tolerance test.

    Peptide
    Cosyntropin
    Outcome
    Not applicableDiscrimination at cortisol cutoff of 18 μg/dL
    Study

    n: not reported in source

    Comparator
    Insulin tolerance test
    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Source sentences

    Summary
    Using a cortisol cut-off of 18 μg/dL during cosyntropin stimulation tests, only cortisol level at 30 min during standard dose cosyntropin test provided discrimination similar to insulin tolerance test.
    4 context sentences
    Summary · context
    We conducted a prospective, randomized pilot study to compare 1 μg IV low dose cosyntropin test, 25 μg IM medium dose cosyntropin test, and 250 μg IM standard dose cosyntropin test to evaluate secondary adrenal insufficiency.
    Summary · context
    Insulin tolerance test was used as the gold standard.
    Summary · context
    The study included patients with hypothalamic/pituitary disease (n  = 10) with at least one pituitary axis deficiency other than ACTH deficiency and controls (n  = 12).
    Summary · context
    All tests were done in random order.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  7. 07HumanNot a test of Cosyntropin aloneRandomized controlled trialOther

    In patients with pituitary disease and controls, the best free cortisol cutoff for low-dose cosyntropin was 0.9 μg/dL.

    In plain wordsThe best free cortisol cutoff was 0.9 μg/dL for low-dose cosyntropin, compared with 1 μg/dL for the insulin tolerance test.

    Peptide
    Cosyntropin
    Outcome
    Not applicableLow-dose free cortisol cutoff
    Study

    n: not reported in source

    Comparator
    Insulin tolerance test
    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Measurements

    Free cortisol cutoff
    0.9 μg/dL
    low dose
    Free cortisol cutoff
    1 μg/dL
    insulin tolerance test

    Source sentences

    Summary
    The best peak free cortisol cut-off levels were 1 μg/dL for insulin tolerance test, 0.9 μg/dL for low dose cosyntropin test, 0.9 μg/dL for medium dose cosyntropin test, and 0.9 μg/dL and 1.3 μg/dL for 30 min and 60 min standard dose cosyntropin test, respectively.
    4 context sentences
    Summary · context
    We conducted a prospective, randomized pilot study to compare 1 μg IV low dose cosyntropin test, 25 μg IM medium dose cosyntropin test, and 250 μg IM standard dose cosyntropin test to evaluate secondary adrenal insufficiency.
    Summary · context
    Insulin tolerance test was used as the gold standard.
    Summary · context
    The study included patients with hypothalamic/pituitary disease (n  = 10) with at least one pituitary axis deficiency other than ACTH deficiency and controls (n  = 12).
    Summary · context
    All tests were done in random order.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  8. 08HumanNot a test of Cosyntropin aloneRandomized controlled trialOther

    In patients with pituitary disease and controls, the best free cortisol cutoff for medium-dose cosyntropin was 0.9 μg/dL.

    In plain wordsThe best free cortisol cutoff was 0.9 μg/dL for medium-dose cosyntropin, compared with 1 μg/dL for the insulin tolerance test.

    Peptide
    Cosyntropin
    Outcome
    Not applicableMedium-dose free cortisol cutoff
    Study

    n: not reported in source

    Comparator
    Insulin tolerance test
    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Measurements

    Free cortisol cutoff
    0.9 μg/dL
    medium dose

    Source sentences

    Summary
    The best peak free cortisol cut-off levels were 1 μg/dL for insulin tolerance test, 0.9 μg/dL for low dose cosyntropin test, 0.9 μg/dL for medium dose cosyntropin test, and 0.9 μg/dL and 1.3 μg/dL for 30 min and 60 min standard dose cosyntropin test, respectively.
    4 context sentences
    Summary · context
    We conducted a prospective, randomized pilot study to compare 1 μg IV low dose cosyntropin test, 25 μg IM medium dose cosyntropin test, and 250 μg IM standard dose cosyntropin test to evaluate secondary adrenal insufficiency.
    Summary · context
    Insulin tolerance test was used as the gold standard.
    Summary · context
    The study included patients with hypothalamic/pituitary disease (n  = 10) with at least one pituitary axis deficiency other than ACTH deficiency and controls (n  = 12).
    Summary · context
    All tests were done in random order.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  9. 09HumanNot a test of Cosyntropin aloneRandomized controlled trialOther

    In patients with pituitary disease and controls, the standard-dose free cortisol cutoff at 30 minutes was 0.9 μg/dL.

    In plain wordsAt 30 minutes, the standard-dose free cortisol cutoff was 0.9 μg/dL, compared with 1 μg/dL for the insulin tolerance test.

    Peptide
    Cosyntropin
    Outcome
    Not applicableStandard-dose free cortisol cutoff at 30 minutes
    Study

    n: not reported in source

    Comparator
    Insulin tolerance test
    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Measurements

    Free cortisol cutoff
    0.9 μg/dL
    standard dose, 30 minutes

    Source sentences

    Summary
    The best peak free cortisol cut-off levels were 1 μg/dL for insulin tolerance test, 0.9 μg/dL for low dose cosyntropin test, 0.9 μg/dL for medium dose cosyntropin test, and 0.9 μg/dL and 1.3 μg/dL for 30 min and 60 min standard dose cosyntropin test, respectively.
    4 context sentences
    Summary · context
    We conducted a prospective, randomized pilot study to compare 1 μg IV low dose cosyntropin test, 25 μg IM medium dose cosyntropin test, and 250 μg IM standard dose cosyntropin test to evaluate secondary adrenal insufficiency.
    Summary · context
    Insulin tolerance test was used as the gold standard.
    Summary · context
    The study included patients with hypothalamic/pituitary disease (n  = 10) with at least one pituitary axis deficiency other than ACTH deficiency and controls (n  = 12).
    Summary · context
    All tests were done in random order.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

  10. 10HumanNot a test of Cosyntropin aloneRandomized controlled trialOther

    In patients with pituitary disease and controls, the standard-dose free cortisol cutoff at 60 minutes was 1.3 μg/dL.

    In plain wordsAt 60 minutes, the standard-dose free cortisol cutoff was 1.3 μg/dL, compared with 1 μg/dL for the insulin tolerance test.

    Peptide
    Cosyntropin
    Outcome
    Not applicableStandard-dose free cortisol cutoff at 60 minutes
    Study

    n: not reported in source

    Comparator
    Insulin tolerance test
    Outcome group
    Diagnostic test performance · Endocrine and hormones

    Measurements

    Free cortisol cutoff
    1.3 μg/dL
    standard dose, 60 minutes

    Source sentences

    Summary
    The best peak free cortisol cut-off levels were 1 μg/dL for insulin tolerance test, 0.9 μg/dL for low dose cosyntropin test, 0.9 μg/dL for medium dose cosyntropin test, and 0.9 μg/dL and 1.3 μg/dL for 30 min and 60 min standard dose cosyntropin test, respectively.
    4 context sentences
    Summary · context
    We conducted a prospective, randomized pilot study to compare 1 μg IV low dose cosyntropin test, 25 μg IM medium dose cosyntropin test, and 250 μg IM standard dose cosyntropin test to evaluate secondary adrenal insufficiency.
    Summary · context
    Insulin tolerance test was used as the gold standard.
    Summary · context
    The study included patients with hypothalamic/pituitary disease (n  = 10) with at least one pituitary axis deficiency other than ACTH deficiency and controls (n  = 12).
    Summary · context
    All tests were done in random order.

    In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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