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Study · Randomized controlled trial · n = 16 · 2018

2 results

Visual systemizing preference in children with autism: A randomized controlled trial of intranasal oxytocin.

Strathearn L, Kim S, Bastian DA, Jung J, Iyengar U, Martinez S, Goin-Kochel RP, Fonagy P

Development and psychopathology17 Jul 2017Cited by 16 (Europe PMC)

PMID28712371 (opens in a new tab)PMCIDPMC5771998 (opens in a new tab)DOI10.1017/s0954579417001018 (opens in a new tab)PepBankPUB-28712371
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In male children with autism spectrum disorder, intranasal oxytocin eliminated the preference for highly systemized pictures that was seen on placebo.

    In plain wordsIn boys with autism, intranasal oxytocin removed their preference for highly organised pictures, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseVisual systemizing preference in children with ASD
    Study

    n = 16

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Intranasal oxytocin eliminated this preference in ASD participants, who now showed a similar response to control subjects on placebo.
    1 context sentence
    Summary · context
    Then, as part of a randomized, double-blind, placebo-controlled crossover study, we examined the effect of intranasal oxytocin on systemizing preferences in 16 male children with ASD, compared with 16 matched controls.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In matched control children, intranasal oxytocin increased the visual preference for more systemized images compared with placebo.

    In plain wordsIn matched control boys, intranasal oxytocin increased their preference for more organised pictures compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseVisual systemizing preference in matched control children
    Study

    n = 16

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    In contrast, control participants increased their visual preference for more systemized images after receiving oxytocin versus placebo.
    1 context sentence
    Summary · context
    Then, as part of a randomized, double-blind, placebo-controlled crossover study, we examined the effect of intranasal oxytocin on systemizing preferences in 16 male children with ASD, compared with 16 matched controls.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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