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Study · Animal study (in vivo) · mouse · 2017

6 results

Co-delivery of a growth factor and a tissue-protective molecule using elastin biopolymers accelerates wound healing in diabetic mice.

Devalliere J, Dooley K, Hu Y, Kelangi SS, Uygun BE, Yarmush ML

Biomaterials30 Jun 2017Cited by 67 (Europe PMC)

PMID28688286 (opens in a new tab)DOI10.1016/j.biomaterials.2017.06.043 (opens in a new tab)PepBankPUB-28688286
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice with full-thickness wounds, ARA290-ELP accelerated wound healing.

    In plain wordsIn diabetic mice, ARA290 on an elastin-like carrier sped up wound healing.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseWound healing rate with ARA290-ELP alone
    Study

    mousen: not reported in source

    full-thickness diabetic wound model
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In this model, ARA290-ELP was found to accelerate healing, notably by increasing angiogenesis in the wound bed.
    1 context sentence
    Summary · context
    We examined the healing effect of ARA290-ELP and KGF-ELP alone or in combination, in a full-thickness diabetic wound model.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice with full-thickness wounds, ARA290-ELP increased angiogenesis in the wound bed.

    In plain wordsIn diabetic mice, ARA290 on an elastin-like carrier increased new blood vessel growth in the wound.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseAngiogenesis in the wound bed with ARA290-ELP
    Study

    mousen: not reported in source

    full-thickness diabetic wound model
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In this model, ARA290-ELP was found to accelerate healing, notably by increasing angiogenesis in the wound bed.
    1 context sentence
    Summary · context
    We examined the healing effect of ARA290-ELP and KGF-ELP alone or in combination, in a full-thickness diabetic wound model.
  3. 03LabIn vitro (cells)Efficacy outcome

    In cell tests, the ARA290-ELP fusion protected cells from apoptosis, so ELP fusion did not diminish ARA290 activity.

    In plain wordsIn cells, ARA290 joined to an elastin-like carrier still protected cells from programmed cell death.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseProtection of cells from apoptosis by ARA290-ELP
    Study

    n: not reported in source

    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ARA290-ELP to protect cells from apoptosis.

Studies that did not test the peptide alone3

In this study, Cibinetide (ARA-290) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cibinetide (ARA-290).

  1. 04AnimalNot a test of Cibinetide (ARA-290) aloneAnimal study (in vivo)Efficacy outcome

    In diabetic mice, co-delivery of KGF-ELP and ARA290-ELP at a 1:4 ratio gave the fastest healing rate and was the most effective wound treatment.

    In plain wordsIn diabetic mice, the 1:4 mix of KGF-ELP and ARA290-ELP healed wounds fastest of the treatments tested.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseHealing rate with 1:4 KGF-ELP to ARA290-ELP co-delivery
    Study

    mousen: not reported in source

    full-thickness diabetic wound model
    Comparator
    ARA290-ELP and KGF-ELP alone; other ratios
    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    We further showed that co-delivery of ARA290 and KGF, with the 1:4 KGF-ELP to ARA290-ELP ratio, was the most effective wound treatment with the fastest healing rate, the thicker granulation tissue and regenerated epidermis after 28 days.
    1 context sentence
    Summary · context
    We examined the healing effect of ARA290-ELP and KGF-ELP alone or in combination, in a full-thickness diabetic wound model.

    In this study, Cibinetide (ARA-290) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cibinetide (ARA-290).

  2. 05AnimalNot a test of Cibinetide (ARA-290) aloneAnimal study (in vivo)Efficacy outcome

    In diabetic mice, 1:4 KGF-ELP to ARA290-ELP co-delivery gave the thicker granulation tissue after 28 days.

    In plain wordsIn diabetic mice, the 1:4 mix of KGF-ELP and ARA290-ELP gave thicker new wound tissue after 28 days.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseGranulation tissue thickness at 28 days with 1:4 co-delivery
    Study

    mousen: not reported in source

    full-thickness diabetic wound model
    Comparator
    ARA290-ELP and KGF-ELP alone; other ratios
    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    We further showed that co-delivery of ARA290 and KGF, with the 1:4 KGF-ELP to ARA290-ELP ratio, was the most effective wound treatment with the fastest healing rate, the thicker granulation tissue and regenerated epidermis after 28 days.
    1 context sentence
    Summary · context
    We examined the healing effect of ARA290-ELP and KGF-ELP alone or in combination, in a full-thickness diabetic wound model.

    In this study, Cibinetide (ARA-290) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cibinetide (ARA-290).

  3. 06AnimalNot a test of Cibinetide (ARA-290) aloneAnimal study (in vivo)Efficacy outcome

    In diabetic mice, 1:4 KGF-ELP to ARA290-ELP co-delivery gave the thicker regenerated epidermis after 28 days.

    In plain wordsIn diabetic mice, the 1:4 mix of KGF-ELP and ARA290-ELP gave a thicker regrown skin surface after 28 days.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseRegenerated epidermis at 28 days with 1:4 co-delivery
    Study

    mousen: not reported in source

    full-thickness diabetic wound model
    Comparator
    ARA290-ELP and KGF-ELP alone; other ratios
    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    We further showed that co-delivery of ARA290 and KGF, with the 1:4 KGF-ELP to ARA290-ELP ratio, was the most effective wound treatment with the fastest healing rate, the thicker granulation tissue and regenerated epidermis after 28 days.
    1 context sentence
    Summary · context
    We examined the healing effect of ARA290-ELP and KGF-ELP alone or in combination, in a full-thickness diabetic wound model.

    In this study, Cibinetide (ARA-290) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cibinetide (ARA-290).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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