In male volunteers, Lupron-induced testosterone deficiency increased femoral adipose tissue meal fatty acid storage rate, fasting and fed LPL activity, and ACS activity versus the no-treatment control and Lupron plus testosterone groups.
In plain wordsLupron raised thigh fat fatty acid storage and related enzyme activity versus untreated men and men given Lupron plus testosterone.
- Peptide
- Leuprolide
- Outcome
- IncreaseFemoral adipose fatty acid storage mechanisms
- Study
n = 32
- Comparator
- No-treatment control and Lupron plus testosterone replacement (L+T)
- Outcome group
- Lipids · Metabolic and weight
- Studied dose
- 7.5 mg · injection · 49 daysAs given in this study (human).
Source sentences
Compared with control and L+T groups, acute testosterone deficiency resulted in greater femoral adipose tissue meal FA storage rates, fasting and fed LPL activity, and ACS activity.
3 context sentences(design, population, supporting numbers)
This was a prospective, randomized trial.
Thirty-two male volunteers ages 18 to 50 participated in these studies.
Volunteers were randomized to receive (1) no treatment (control), (2) injections (7.5 mg) of Lupron®, or (3) Lupron and testosterone (L+T) replacement for 49 days, resulting in 4 weeks of sex steroid suppression in the Lupron group.