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Study · Randomized controlled trial · n = 116 · 2017

3 results

Kinetics and Dose Dependency of Intranasal Oxytocin Effects on Amygdala Reactivity.

Spengler FB, Schultz J, Scheele D, Essel M, Maier W, Heinrichs M, Hurlemann R

Biological psychiatry10 May 2017Cited by 206 (Europe PMC)

PMID28629540 (opens in a new tab)DOI10.1016/j.biopsych.2017.04.015 (opens in a new tab)PepBankPUB-28629540
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy men, oxytocin inhibited amygdala responses to fear most effectively 45 to 70 minutes after a 24 international unit dose.

    In plain wordsIn healthy men, oxytocin reduced the brain's fear response most strongly 45 to 70 minutes after a 24-unit dose.

    Peptide
    Oxytocin
    Outcome
    DecreaseAmygdala response to fear (dose and latency)
    Study

    n = 116

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    24 international units · intranasalAs given in this study (human).

    Source sentences

    Summary
    Our results indicate that the OXT-induced inhibition of amygdala responses to fear was most effective in a time window between 45 and 70 minutes after administration of a dose of 24 international units.
    1 context sentence
    Summary · context
    To address this highly relevant issue, a total of 116 healthy men underwent functional magnetic resonance imaging using a randomized, double-blind, placebo-controlled crossover study design.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy men, the oxytocin effect on amygdala reactivity was most evident in subjects with high autistic-like traits.

    In plain wordsIn healthy men, oxytocin's effect on amygdala reactivity was strongest in those with more autistic-like traits.

    Peptide
    Oxytocin
    Outcome
    DecreaseAmygdala effect by autistic-like traits
    Study

    n = 116

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Furthermore, the observed effect was most evident in subjects scoring high on measures of autistic-like traits.
    1 context sentence
    Summary · context
    To address this highly relevant issue, a total of 116 healthy men underwent functional magnetic resonance imaging using a randomized, double-blind, placebo-controlled crossover study design.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy men, oxytocin reduced an emotional bias in the perception of ambiguous faces.

    In plain wordsIn healthy men, oxytocin reduced emotional bias when judging ambiguous faces.

    Peptide
    Oxytocin
    Outcome
    DecreaseEmotional bias in perception of ambiguous faces
    Study

    n = 116

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Behavioral response patterns suggest that OXT specifically reduced an emotional bias in the perception of ambiguous faces.
    1 context sentence
    Summary · context
    To address this highly relevant issue, a total of 116 healthy men underwent functional magnetic resonance imaging using a randomized, double-blind, placebo-controlled crossover study design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials2

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

2 trials · 1 completed · 1 stopped early · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 2NCT06945926

The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery

Zhejiang Universityn = 2271 Jun 2025 to 2 Jun 2026

Cervical Spinal Stenosis · Thoracic Spinal Stenosis · Lumbar Spinal Stenosis · Rotator Cuff Injury · Femoral Head Necrosis · Spinal Trauma · Knee Joint Injury

Trial pageClinicalTrials.govUpdated 20 Aug 2026
TerminatedPhase 1/2NCT03863288

Dose Response Relationship of Oxytocin on Irritability in Youths

University of Nebraskan = 6018 Feb 2022 to 27 Feb 2024

Irritable Mood

Trial pageClinicalTrials.govUpdated 14 Mar 2025

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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