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Study · Not a test of the peptide alone · 2017

1 result

Adiponectin improves the osteointegration of titanium implant under diabetic conditions by reversing mitochondrial dysfunction via the AMPK pathway in vivo and in vitro.

Hu XF, Wang L, Wang L, Lu YZ, Xiang G, Wu ZX, Yan YB, Zhang Y, Zhao X, Zang Y, Shi L, Lei W, Feng YF

Acta biomaterialia15 Jun 2017Cited by 49 (Europe PMC)

PMID28624657 (opens in a new tab)DOI10.1016/j.actbio.2017.06.020 (opens in a new tab)PepBankPUB-28624657
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Efficacy outcome

    In rat osteoblasts under diabetic conditions, AICAR showed beneficial effects similar to adiponectin treatment, without separate outcome results.

    In plain wordsIn cells, AICAR showed benefits similar to adiponectin, but the abstract did not specify individual AICAR results.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedBeneficial cellular effects
    Study

    ratn: not reported in source

    primary osteoblasts on titanium in diabetic milieu
    Comparator
    adiponectin treatment
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Furthermore, AICAR showed beneficial effects similar to APN treatment, while the protective effects of APN were abolished when AMPK activation was blocked by Compound C.
    1 context sentence
    Summary · context
    To test this hypothesis, we incubated primary rat osteoblasts on TI and tested the cellular behaviors when subjected to normal milieu (NM), diabetic milieu (DM), DM+APN, DM+AICAR (AMPK activator) and DM+APN+Compound C (AMPK inhibitor).

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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