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Study · Animal study (in vivo) · rat · 2017

5 results

Cerebrolysin prevents deficits in social behavior, repetitive conduct, and synaptic inhibition in a rat model of autism.

Cuevas-Olguin R, Roychowdhury S, Banerjee A, Garcia-Oscos F, Esquivel-Rendon E, Bringas ME, Kilgard MP, Flores G, Atzori M

Journal of neuroscience research13 Jun 2017Cited by 27 (Europe PMC)

PMID28609577 (opens in a new tab)DOI10.1002/jnr.24072 (opens in a new tab)PepBankPUB-28609577
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In valproic acid-exposed rats, Cerebrolysin improved behavioral performance assessed with social interaction, Y-maze, and plus-maze versus saline.

    In plain wordsIn rats exposed to valproic acid, Cerebrolysin improved behavioral performance compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseBehavioral performance
    Study

    ratn: not reported in source

    Valproic acid-exposed rat offspring
    Comparator
    Saline
    Outcome group
    Autism core symptoms · Nervous system and cognition
    Studied dose
    2.5 mL/Kg · i.p. · 15 daysAs given in this study (rat).

    Source sentences

    Summary
    Comparison between saline vs. CBL-injected VPA animals shows that CBL treatment improves behavioral as well as synaptic impairments, measured by behavioral performance (social interaction, Y-maze, plus-maze)
    2 context sentences
    Summary · context
    In the present study, we tested the effect of CBL treatment (daily injection of 2.5 mL/Kg i.p. during 15 days) on a rat model of ASD.
    Summary · context
    This was based on the offspring (43 male and 51 female pups) of a pregnant female rat injected with valproic acid (VPA, 600 mg/Kg) at the embryonic day 12.5, which previous work has shown to display extensive behavioral, as well as synaptic impairment.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In valproic acid-exposed rats, Cerebrolysin improved maximal inhibitory GABA receptor-mediated synaptic current response versus saline.

    In plain wordsIn rats exposed to valproic acid, Cerebrolysin improved maximal inhibitory synaptic current response compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableMaximal GABA receptor-mediated synaptic current response
    Study

    ratn: not reported in source

    Valproic acid-exposed rat offspring
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 mL/Kg · i.p. · 15 daysAs given in this study (rat).

    Source sentences

    Summary
    maximal response of inhibitory γ-amino butyric acid type A receptor (GABAA R)-mediated synaptic currents
    3 context sentences
    Summary · context
    Comparison between saline vs. CBL-injected VPA animals shows that CBL treatment improves behavioral as well as synaptic impairments
    Summary · context
    In the present study, we tested the effect of CBL treatment (daily injection of 2.5 mL/Kg i.p. during 15 days) on a rat model of ASD.
    Summary · context
    This was based on the offspring (43 male and 51 female pups) of a pregnant female rat injected with valproic acid (VPA, 600 mg/Kg) at the embryonic day 12.5, which previous work has shown to display extensive behavioral, as well as synaptic impairment.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In valproic acid-exposed rats, Cerebrolysin improved kinetic properties of inhibitory synaptic currents versus saline.

    In plain wordsIn rats exposed to valproic acid, Cerebrolysin improved inhibitory synaptic current kinetics compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableSynaptic current kinetics
    Study

    ratn: not reported in source

    Valproic acid-exposed rat offspring
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 mL/Kg · i.p. · 15 daysAs given in this study (rat).

    Source sentences

    Summary
    as well as their kinetic properties and adrenergic and muscarinic modulation.
    3 context sentences
    Summary · context
    Comparison between saline vs. CBL-injected VPA animals shows that CBL treatment improves behavioral as well as synaptic impairments
    Summary · context
    In the present study, we tested the effect of CBL treatment (daily injection of 2.5 mL/Kg i.p. during 15 days) on a rat model of ASD.
    Summary · context
    This was based on the offspring (43 male and 51 female pups) of a pregnant female rat injected with valproic acid (VPA, 600 mg/Kg) at the embryonic day 12.5, which previous work has shown to display extensive behavioral, as well as synaptic impairment.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In valproic acid-exposed rats, Cerebrolysin improved adrenergic modulation of inhibitory synaptic currents versus saline.

    In plain wordsIn rats exposed to valproic acid, Cerebrolysin improved adrenergic control of inhibitory synaptic currents compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableAdrenergic modulation
    Study

    ratn: not reported in source

    Valproic acid-exposed rat offspring
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 mL/Kg · i.p. · 15 daysAs given in this study (rat).

    Source sentences

    Summary
    as well as their kinetic properties and adrenergic and muscarinic modulation.
    3 context sentences
    Summary · context
    Comparison between saline vs. CBL-injected VPA animals shows that CBL treatment improves behavioral as well as synaptic impairments
    Summary · context
    In the present study, we tested the effect of CBL treatment (daily injection of 2.5 mL/Kg i.p. during 15 days) on a rat model of ASD.
    Summary · context
    This was based on the offspring (43 male and 51 female pups) of a pregnant female rat injected with valproic acid (VPA, 600 mg/Kg) at the embryonic day 12.5, which previous work has shown to display extensive behavioral, as well as synaptic impairment.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In valproic acid-exposed rats, Cerebrolysin improved muscarinic modulation of inhibitory synaptic currents versus saline.

    In plain wordsIn rats exposed to valproic acid, Cerebrolysin improved muscarinic control of inhibitory synaptic currents compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableMuscarinic modulation
    Study

    ratn: not reported in source

    Valproic acid-exposed rat offspring
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 mL/Kg · i.p. · 15 daysAs given in this study (rat).

    Source sentences

    Summary
    as well as their kinetic properties and adrenergic and muscarinic modulation.
    3 context sentences
    Summary · context
    Comparison between saline vs. CBL-injected VPA animals shows that CBL treatment improves behavioral as well as synaptic impairments
    Summary · context
    In the present study, we tested the effect of CBL treatment (daily injection of 2.5 mL/Kg i.p. during 15 days) on a rat model of ASD.
    Summary · context
    This was based on the offspring (43 male and 51 female pups) of a pregnant female rat injected with valproic acid (VPA, 600 mg/Kg) at the embryonic day 12.5, which previous work has shown to display extensive behavioral, as well as synaptic impairment.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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