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Study · Randomized controlled trial · n = 24 · 2017

3 results

Sex-specific effects of intranasal oxytocin on thermal pain perception: A randomised, double-blind, placebo-controlled cross-over study.

Tracy LM, Labuschagne I, Georgiou-Karistianis N, Gibson SJ, Giummarra MJ

Psychoneuroendocrinology3 Jun 2017Cited by 18 (Europe PMC)

PMID28601750 (opens in a new tab)DOI10.1016/j.psyneuen.2017.05.028 (opens in a new tab)PepBankPUB-28601750
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy, pain-free controls, intranasal oxytocin did not change the perceived intensity of noxious heat stimuli compared with placebo.

    In plain wordsIn healthy people without pain, oxytocin did not change how intense painful heat felt compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changePerceived intensity of noxious heat
    Study

    n = 24

    Comparator
    Placebo
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Compared with placebo, intranasal oxytocin increased the perceived intensity of noxious heat stimuli
    2 context sentences
    Summary · context
    or healthy, pain-free controls.
    Summary · context
    Participants were 24 individuals with CNSP lasting >12months (eight women), and 24 age- and sex-matched healthy, pain-free controls. In a randomised double-blind, placebo-controlled, cross-over study, participants attended two sessions, self-administering intranasal oxytocin (24 IU) in one session,…
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women with chronic neck and shoulder pain, intranasal oxytocin increased the perceived intensity of noxious heat stimuli compared with placebo.

    In plain wordsIn women with chronic neck and shoulder pain, oxytocin made painful heat feel more intense than placebo did.

    Peptide
    Oxytocin
    Outcome
    IncreasePerceived intensity of noxious heat
    Study

    n = 8

    Comparator
    Placebo
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Measurements

    Cohen's d
    0.71
    women with CNSP

    Source sentences

    Summary
    Compared with placebo, intranasal oxytocin increased the perceived intensity of noxious heat stimuli in women with CNSP (Cohen's d=0.71), but not in men with CNSP, or healthy, pain-free controls.
    1 context sentence
    Summary · context
    Participants were 24 individuals with CNSP lasting >12months (eight women), and 24 age- and sex-matched healthy, pain-free controls. In a randomised double-blind, placebo-controlled, cross-over study, participants attended two sessions, self-administering intranasal oxytocin (24 IU) in one session,…
  3. 03HumanRandomized controlled trialEfficacy outcome

    In men with chronic neck and shoulder pain, intranasal oxytocin did not change the perceived intensity of noxious heat stimuli compared with placebo.

    In plain wordsIn men with chronic neck and shoulder pain, oxytocin did not change how intense painful heat felt compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changePerceived intensity of noxious heat
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Compared with placebo, intranasal oxytocin increased the perceived intensity of noxious heat stimuli in women with CNSP (Cohen's d=0.71), but not in men with CNSP
    1 context sentence
    Summary · context
    Participants were 24 individuals with CNSP lasting >12months (eight women), and 24 age- and sex-matched healthy, pain-free controls. In a randomised double-blind, placebo-controlled, cross-over study, participants attended two sessions, self-administering intranasal oxytocin (24 IU) in one session,…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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