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Study · Animal study (in vivo) · rabbit · 2018

6 results

The use of mechano growth factor to prevent cartilage degeneration in knee osteoarthritis.

Song Y, Xu K, Xu K, Yu C, Dong L, Chen P, Lv Y, Chiang MYM, Li L, Liu W, Yang L

Journal of tissue engineering and regenerative medicine6 Oct 2017Cited by 8 (Europe PMC)

PMID28599103 (opens in a new tab)DOI10.1002/term.2493 (opens in a new tab)PepBankPUB-28599103
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In a rabbit knee joint osteoarthritis model, 2 weeks of MGF treatment inhibited cartilage degeneration.

    In plain wordsIn rabbits with knee arthritis, MGF treatment slowed cartilage damage.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseCartilage degeneration in rabbit knee OA
    Study

    rabbitn: not reported in source

    knee joint osteoarthritis
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.1-10-μg/ml · 2 weeksAs given in this study (rabbit).

    Source sentences

    Summary
    In a rabbit knee joint OA model, cartilage degeneration was inhibited after 2 weeks of treatment with 0.1-10-μg/ml MGF.
    1 context sentence
    Summary · context
    Here, the capability of mechano growth factor-C24E (MGF) to prevent osteoarthritic cartilage degeneration was evaluated in vitro and in vivo.
  2. 02LabIn vitro (cells)Efficacy outcome

    In cultured human osteoarthritis chondrocytes, MGF inhibited pathological apoptosis.

    In plain wordsIn human arthritic cartilage cells in a dish, MGF reduced cell death.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseApoptosis of OA chondrocytes
    Study

    humann: not reported in source

    cultured OA chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10-60-ng/ml · 12 hrAs given in this study (human).

    Source sentences

    Summary
    This study demonstrated that MGF treatment can inhibit the pathological apoptosis of OA chondrocytes and promote the proliferation, migration, and matrix synthesis of the chondrocytes.
    1 context sentence
    Summary · context
    Using in vitro cultured human OA chondrocytes treated with 10-60-ng/ml MGF for 12 hr, we detected the cell proliferation, migration, and anabolism of OA chondrocytes.
  3. 03LabIn vitro (cells)Efficacy outcome

    In cultured human osteoarthritis chondrocytes, MGF promoted proliferation.

    In plain wordsIn human arthritic cartilage cells in a dish, MGF helped the cells to multiply.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseProliferation of OA chondrocytes
    Study

    humann: not reported in source

    cultured OA chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10-60-ng/ml · 12 hrAs given in this study (human).

    Source sentences

    Summary
    This study demonstrated that MGF treatment can inhibit the pathological apoptosis of OA chondrocytes and promote the proliferation, migration, and matrix synthesis of the chondrocytes.
    1 context sentence
    Summary · context
    Using in vitro cultured human OA chondrocytes treated with 10-60-ng/ml MGF for 12 hr, we detected the cell proliferation, migration, and anabolism of OA chondrocytes.
  4. 04LabIn vitro (cells)Efficacy outcome

    In cultured human osteoarthritis chondrocytes, MGF promoted migration.

    In plain wordsIn human arthritic cartilage cells in a dish, MGF helped the cells to move.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMigration of OA chondrocytes
    Study

    humann: not reported in source

    cultured OA chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10-60-ng/ml · 12 hrAs given in this study (human).

    Source sentences

    Summary
    This study demonstrated that MGF treatment can inhibit the pathological apoptosis of OA chondrocytes and promote the proliferation, migration, and matrix synthesis of the chondrocytes.
    1 context sentence
    Summary · context
    Using in vitro cultured human OA chondrocytes treated with 10-60-ng/ml MGF for 12 hr, we detected the cell proliferation, migration, and anabolism of OA chondrocytes.
  5. 05LabIn vitro (cells)Efficacy outcome

    In cultured human osteoarthritis chondrocytes, MGF promoted matrix synthesis.

    In plain wordsIn human arthritic cartilage cells in a dish, MGF increased the making of cartilage matrix.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMatrix synthesis by OA chondrocytes
    Study

    humann: not reported in source

    cultured OA chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10-60-ng/ml · 12 hrAs given in this study (human).

    Source sentences

    Summary
    This study demonstrated that MGF treatment can inhibit the pathological apoptosis of OA chondrocytes and promote the proliferation, migration, and matrix synthesis of the chondrocytes.
    1 context sentence
    Summary · context
    Using in vitro cultured human OA chondrocytes treated with 10-60-ng/ml MGF for 12 hr, we detected the cell proliferation, migration, and anabolism of OA chondrocytes.
  6. 06LabIn vitro (cells)Mechanism

    In osteoarthritis chondrocytes, the delay of cartilage degeneration by MGF was partly mediated by the unfolded protein response regulated by PERK.

    In plain wordsIn arthritic cartilage cells, MGF slowed damage partly through a cell stress pathway controlled by PERK.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableRole of PERK-regulated unfolded protein response
    Study

    humann: not reported in source

    cultured OA chondrocytes
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results also demonstrate that the degeneration of OA cartilage can be delayed by MGF treatment partially via unfolded protein response regulated by protein kinase RNA-like endoplasmic reticulum kinase and suggest a potential therapeutic application of MGF for OA treatment.
    1 context sentence
    Summary · context
    Furthermore, protein kinase RNA-like endoplasmic reticulum kinase was knocked down via small interfering RNA to illuminate the potential mechanism of MGF's treatment of OA.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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