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Study · Animal study (in vivo) · rat · 2017

5 results

Influence of ACTG4-7-PGP (Semax) on Morphofunctional State of Hepatocytes in Chronic Emotional and Painful Stress.

Ivanov AV, Bobyntsev II, Shepeleva OM, Kryukov AA, Andreeva LA, Myasoedov NF

Bulletin of experimental biology and medicine1 May 2017

PMID28577097 (opens in a new tab)DOI10.1007/s10517-017-3748-4 (opens in a new tab)PepBankPUB-28577097
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats under chronic emotional and painful stress, Semax normalized the protein synthesis function of the liver in a dose-dependent manner.

    In plain wordsIn stressed rats, Semax brought liver protein production back toward normal, depending on dose.

    Peptide
    Semax
    Outcome
    Direction not reportedProtein synthesis function of the liver
    Study

    ratn: not reported in source

    male Wistar rats, chronic emotional and painful stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    5, 50, 150 and 450 μg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    A dose-dependent stress-limiting effect of the peptide was observed: it normalized the protein synthesis function of the liver
    1 context sentence
    Summary · context
    We studied the effect of intraperitoneal administration of peptide ACTG4-7-PGP to male Wistar rats in doses of 5, 50, 150, and 450 μg/kg on the morphofunctional state of hepatocytes in chronic emotional and painful stress.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats under chronic emotional and painful stress, Semax normalized serum ALT activity.

    In plain wordsIn stressed rats, Semax brought the liver enzyme ALT in blood back toward normal.

    Peptide
    Semax
    Outcome
    Direction not reportedSerum ALT activity
    Study

    ratn: not reported in source

    male Wistar rats, chronic emotional and painful stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    5, 50, 150 and 450 μg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    it normalized the protein synthesis function of the liver and serum activity of ALT
    1 context sentence
    Summary · context
    We studied the effect of intraperitoneal administration of peptide ACTG4-7-PGP to male Wistar rats in doses of 5, 50, 150, and 450 μg/kg on the morphofunctional state of hepatocytes in chronic emotional and painful stress.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats under chronic emotional and painful stress, Semax had an anticytolytic effect that increased with dose, decreasing hepatocyte cytolysis.

    In plain wordsIn stressed rats, Semax reduced liver cell breakdown, more at higher doses.

    Peptide
    Semax
    Outcome
    DecreaseHepatocyte cytolysis
    Study

    ratn: not reported in source

    male Wistar rats, chronic emotional and painful stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    5, 50, 150 and 450 μg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    The anticytolytic effect of the peptide increased with increasing its dose against the background of the increase in the relative number of multinucleated and multinucleolated cells and deceleration of the recovery of serum protein concentration.
    2 context sentences
    Summary · context
    The decrease of hepatocyte cytolysis against the background of more intense morphological signs of protein synthesis processes
    Summary · context
    We studied the effect of intraperitoneal administration of peptide ACTG4-7-PGP to male Wistar rats in doses of 5, 50, 150, and 450 μg/kg on the morphofunctional state of hepatocytes in chronic emotional and painful stress.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats under chronic emotional and painful stress, Semax was accompanied by an increase in the relative number of multinucleated and multinucleolated liver cells.

    In plain wordsIn stressed rats, Semax was accompanied by more liver cells with several nuclei or nucleoli.

    Peptide
    Semax
    Outcome
    IncreaseRelative number of multinucleated and multinucleolated hepatocytes
    Study

    ratn: not reported in source

    male Wistar rats, chronic emotional and painful stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    5, 50, 150 and 450 μg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    against the background of the increase in the relative number of multinucleated and multinucleolated cells
    1 context sentence
    Summary · context
    We studied the effect of intraperitoneal administration of peptide ACTG4-7-PGP to male Wistar rats in doses of 5, 50, 150, and 450 μg/kg on the morphofunctional state of hepatocytes in chronic emotional and painful stress.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats under chronic emotional and painful stress, Semax was accompanied by deceleration of the recovery of serum protein concentration.

    In plain wordsIn stressed rats, Semax was accompanied by slower recovery of blood protein levels.

    Peptide
    Semax
    Outcome
    DecreaseRecovery of serum protein concentration
    Study

    ratn: not reported in source

    male Wistar rats, chronic emotional and painful stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    5, 50, 150 and 450 μg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    deceleration of the recovery of serum protein concentration.
    1 context sentence
    Summary · context
    We studied the effect of intraperitoneal administration of peptide ACTG4-7-PGP to male Wistar rats in doses of 5, 50, 150, and 450 μg/kg on the morphofunctional state of hepatocytes in chronic emotional and painful stress.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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