Skip to content

Study · In vitro (cells) · 2017

5 results

MGF E peptide pretreatment improves collagen synthesis and cell proliferation of injured human ACL fibroblasts via MEK-ERK1/2 signaling pathway.

Sha Y, Afandi R, Zhang B, Yang L, Lv Y

Growth factors (Chur, Switzerland)1 Feb 2017Cited by 14 (Europe PMC)

PMID28553731 (opens in a new tab)DOI10.1080/08977194.2017.1327856 (opens in a new tab)PepBankPUB-28553731
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In injured human ACL fibroblasts, MGF E peptide pretreatment decreased type I/III collagen synthesis at 0 h.

    In plain wordsIn cells, MGF E peptide pretreatment lowered collagen production right after injury in ligament cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseType I/III collagen synthesis at 0 h
    Study

    humann: not reported in source

    Injured ACL fibroblasts
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    exogenous MGF E peptide decreased the type I/III collagen synthesis at 0 h
    1 context sentence
    Summary · context
    To verify whether mechano-growth factor (MGF) E peptide can restore the cell proliferation of injured ACL fibroblasts, ACL fibroblasts pretreated with MGF E peptide were subjected to injurious stretch and the outcomes were evaluated at 0 and 24 h.
  2. 02LabIn vitro (cells)Efficacy outcome

    In injured human ACL fibroblasts, MGF E peptide pretreatment improved type III collagen synthesis at 24 h.

    In plain wordsIn cells, MGF E peptide pretreatment improved collagen production 24 hours after injury in ligament cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseType III collagen synthesis at 24 h
    Study

    humann: not reported in source

    Injured ACL fibroblasts
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    improved the type III collagen synthesis at 24 h.
    1 context sentence
    Summary · context
    To verify whether mechano-growth factor (MGF) E peptide can restore the cell proliferation of injured ACL fibroblasts, ACL fibroblasts pretreated with MGF E peptide were subjected to injurious stretch and the outcomes were evaluated at 0 and 24 h.
  3. 03LabIn vitro (cells)Mechanism

    In injured human ACL fibroblasts, MGF E peptide decreased MMP-2 activity and expression.

    In plain wordsIn cells, MGF E peptide lowered the activity of a tissue-breakdown enzyme in injured ligament cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseMMP-2 activity and expression
    Study

    humann: not reported in source

    Injured ACL fibroblasts
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It decreased the MMP-2 activity/expression of injured ACL fibroblasts.
    1 context sentence
    Summary · context
    To verify whether mechano-growth factor (MGF) E peptide can restore the cell proliferation of injured ACL fibroblasts, ACL fibroblasts pretreated with MGF E peptide were subjected to injurious stretch and the outcomes were evaluated at 0 and 24 h.
  4. 04LabIn vitro (cells)Efficacy outcome

    In injured human ACL fibroblasts, MGF E peptide accelerated cell proliferation.

    In plain wordsIn cells, MGF E peptide made injured ligament cells multiply faster.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseCell proliferation
    Study

    humann: not reported in source

    Injured ACL fibroblasts
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MGF E peptide accelerated the cell proliferation
    1 context sentence
    Summary · context
    To verify whether mechano-growth factor (MGF) E peptide can restore the cell proliferation of injured ACL fibroblasts, ACL fibroblasts pretreated with MGF E peptide were subjected to injurious stretch and the outcomes were evaluated at 0 and 24 h.
  5. 05LabIn vitro (cells)Mechanism

    In injured human ACL fibroblasts, MGF E peptide accelerated cell proliferation via the MEK-ERK1/2 signaling pathway.

    In plain wordsIn cells, MGF E peptide sped up ligament cell growth through a signal pathway called MEK-ERK1/2.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableMEK-ERK1/2 pathway in proliferation
    Study

    humann: not reported in source

    Injured ACL fibroblasts
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Besides, MGF E peptide accelerated the cell proliferation via MEK-ERK1/2 signaling pathway.
    1 context sentence
    Summary · context
    To verify whether mechano-growth factor (MGF) E peptide can restore the cell proliferation of injured ACL fibroblasts, ACL fibroblasts pretreated with MGF E peptide were subjected to injurious stretch and the outcomes were evaluated at 0 and 24 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.