The COOH-terminus of the IGF-1Ec Isoform Enhances the Proliferation and Migration of Human MCF-7 Breast Cancer Cells.

Christopoulos PF, Papageorgiou E, Petraki C, Koutsilieris M

Anticancer research1 Jun 2017Cited by 3 (Europe PMC)

PMID28551627DOI10.21873/anticanres.11643PepBankPUB-28551627

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In estrogen-responsive MCF-7 breast cancer cells, exogenous hEc peptide stimulated proliferation.
In plain wordsIn cells, added hEc peptide made one type of breast cancer cell multiply faster.
Peptide
MGF / PEG-MGF
Outcome
IncreaseMCF-7 cell proliferation after exogenous hEc
Study
humann: not reported in source
MCF-7 breast cancer cells
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
We found that exogenous administration of hEc stimulated the proliferation of estrogen-responsive MCF-7
2 context sentences(design, population, supporting numbers)
Summary · context
Synthetic hEc peptide was administrated to MCF-7 and MDA-MB-231 breast cancer cells.
Summary · context
In addition MCF-7 cells were engineered to overexpress hEc.
Report a problemFND-2855162701
02LabIn vitro (cells)Efficacy outcome
In hormone-resistant MDA-MB-231 breast cancer cells, exogenous hEc peptide did not stimulate proliferation.
In plain wordsIn cells, added hEc peptide did not make hormone-resistant breast cancer cells multiply faster.
Peptide
MGF / PEG-MGF
Outcome
No significant changeMDA-MB-231 cell proliferation after exogenous hEc
Study
humann: not reported in source
MDA-MB-231 breast cancer cells
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
but not that of hormone-resistant MDA-MB-231 cells.
2 context sentences(design, population, supporting numbers)
Summary · context
Synthetic hEc peptide was administrated to MCF-7 and MDA-MB-231 breast cancer cells.
Summary · context
In addition MCF-7 cells were engineered to overexpress hEc.
Report a problemFND-2855162702

Studies that did not test the peptide alone3

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

03LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Efficacy outcome
MCF-7 cells engineered to overexpress hEc had a higher proliferation rate than mock and wild-type cells.
In plain wordsIn cells engineered to make more hEc, breast cancer cells multiplied faster than unmodified cells.
Peptide
MGF / PEG-MGF
Outcome
IncreaseProliferation rate in hEc-overexpressing MCF-7 cells
Study
humann: not reported in source
MCF-7 cells stably overexpressing hEc
Comparator
Mock and wild-type cells
Outcome group
Tumor growth · Cancer
Source sentences
Summary
In addition, MCF-7 cells stably-overexpressing hEc acquired an increased proliferation rate
2 context sentences(design, population, supporting numbers)
Summary · context
Synthetic hEc peptide was administrated to MCF-7 and MDA-MB-231 breast cancer cells.
Summary · context
In addition MCF-7 cells were engineered to overexpress hEc.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-2855162703
04LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Efficacy outcome
MCF-7 cells engineered to overexpress hEc had a higher migratory capacity than mock and wild-type cells.
In plain wordsIn cells engineered to make more hEc, breast cancer cells moved more than unmodified cells.
Peptide
MGF / PEG-MGF
Outcome
IncreaseMigratory capacity in hEc-overexpressing MCF-7 cells
Study
humann: not reported in source
MCF-7 cells stably overexpressing hEc
Comparator
Mock and wild-type cells
Outcome group
Tumor growth · Cancer
Source sentences
Summary
acquired an increased proliferation rate and migratory capacity, as well as, enhanced ERK1/2 phosphorylation, compared to mock and wild-type cells.
2 context sentences(design, population, supporting numbers)
Summary · context
Synthetic hEc peptide was administrated to MCF-7 and MDA-MB-231 breast cancer cells.
Summary · context
In addition MCF-7 cells were engineered to overexpress hEc.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-2855162704
05LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism
MCF-7 cells engineered to overexpress hEc had enhanced ERK1/2 phosphorylation compared with mock and wild-type cells.
In plain wordsIn cells engineered to make more hEc, a growth signal called ERK1/2 was more active than in unmodified cells.
Peptide
MGF / PEG-MGF
Outcome
IncreaseERK1/2 phosphorylation in hEc-overexpressing MCF-7 cells
Study
humann: not reported in source
MCF-7 cells stably overexpressing hEc
Comparator
Mock and wild-type cells
Outcome group
Tumor growth · Cancer
Source sentences
Summary
as well as, enhanced ERK1/2 phosphorylation, compared to mock and wild-type cells.
2 context sentences(design, population, supporting numbers)
Summary · context
Synthetic hEc peptide was administrated to MCF-7 and MDA-MB-231 breast cancer cells.
Summary · context
In addition MCF-7 cells were engineered to overexpress hEc.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-2855162705

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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