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Study · In vitro (cells) · 2016

3 results

[Molecular aspects of vasoprotective peptide KED activity during atherosclerosis and restenosis].

Kozlov KL, Bolotov II, Linkova NS, Drobintseva AO, Khavinson VK, Dyakonov MM, Kozina LS

Advances in gerontology = Uspekhi gerontologii1 Jan 2016Cited by 4 (Europe PMC)

PMID28539025 (opens in a new tab)PepBankPUB-28539025
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured endothelium, KED normalized endothelin-1 expression elevated during atherosclerosis and restenosis.

    In plain wordsIn cells, KED normalized the high endothelin-1 expression associated with atherosclerosis and restenosis.

    Peptide
    Vesugen (KED)
    Outcome
    DecreaseEndothelin-1 expression
    Study

    n: not reported in source

    normal, atherosclerotic and restenotic endothelium in vitro
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was shown, that KED peptide has normalized endothelin-1 expression, which increased during atherosclerosis and restenosis.
    1 context sentence
    Summary · context
    The goal of investigation was to study the KED peptide effect on signal molecules expression in normal, atherosclerotic and restenotic endothelium in vitro.
  2. 02LabIn vitro (cells)Mechanism

    In cultured endothelium, KED restored cell interactions through connexin expression.

    In plain wordsIn cells, KED restored cell interactions through connexin expression.

    Peptide
    Vesugen (KED)
    Outcome
    Direction not reportedConnexin-mediated cell interactions
    Study

    n: not reported in source

    normal, atherosclerotic and restenotic endothelium in vitro
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KED peptide also restorates cells interactions by connexin expression.
    1 context sentence
    Summary · context
    The goal of investigation was to study the KED peptide effect on signal molecules expression in normal, atherosclerotic and restenotic endothelium in vitro.
  3. 03LabIn vitro (cells)Mechanism

    In cultured endothelium, KED increased sirtuin1 expression.

    In plain wordsIn cells, KED increased sirtuin1 expression.

    Peptide
    Vesugen (KED)
    Outcome
    IncreaseSirtuin1 expression
    Study

    n: not reported in source

    normal, atherosclerotic and restenotic endothelium in vitro
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Geroprotective effect of KED peptide is realized by increasing of sirtuin1 expression, which has took part in DNA reparation.
    1 context sentence
    Summary · context
    The goal of investigation was to study the KED peptide effect on signal molecules expression in normal, atherosclerotic and restenotic endothelium in vitro.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 17:05 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

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