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Study · Not a test of the peptide alone · 2017

2 results

Comparison of the induction of c-fos-eGFP and Fos protein in the rat spinal cord and hypothalamus resulting from subcutaneous capsaicin or formalin injection.

Motojima Y, Matsuura T, Yoshimura M, Hashimoto H, Saito R, Ueno H, Maruyama T, Sonoda S, Suzuki H, Kawasaki M, Ohnishi H, Sakai A, Ueta Y

Neuroscience18 May 2017Cited by 14 (Europe PMC)

PMID28527956 (opens in a new tab)DOI10.1016/j.neuroscience.2017.05.015 (opens in a new tab)PepBankPUB-28527956
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In c-fos-eGFP transgenic rats, capsaicin or formalin injection induced eGFP in the body's own oxytocin neurons of the paraventricular and supraoptic nuclei.

    In plain wordsIn rats, painful injections activated the body's own oxytocin-producing nerve cells, shown by a green fluorescent marker.

    Peptide
    Oxytocin
    Outcome
    IncreaseeGFP induction in oxytocin neurons
    Study

    ratn: not reported in source

    c-fos-eGFP transgenic and wild-type rats with subcutaneous capsaicin or formalin injection
    Comparator
    Ethanol or saline injection
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    Induction of eGFP in the OXT neurons was observed after capsaicin or formalin treatment, while Fos-LI in the OXT neurons was observed only after formalin treatment.
    2 context sentences
    Summary · context
    Capsaicin solution (15%) or formalin (5%) was subcutaneously injected bilaterally into the hind paws (100μL per each paw) of adult male c-fos-eGFP transgenic or wild-type rats.
    Summary · context
    Control rats were injected with ethanol or physiological saline respectively.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In wild-type rats, Fos immunoreactivity in the body's own oxytocin neurons was observed only after formalin treatment, not after capsaicin.

    In plain wordsIn rats, the body's own oxytocin nerve cells showed a Fos activity marker after formalin but not after capsaicin.

    Peptide
    Oxytocin
    Outcome
    MixedFos-LI in oxytocin neurons
    Study

    ratn: not reported in source

    c-fos-eGFP transgenic and wild-type rats with subcutaneous capsaicin or formalin injection
    Comparator
    Ethanol or saline injection
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    while Fos-LI in the OXT neurons was observed only after formalin treatment.
    2 context sentences
    Summary · context
    Capsaicin solution (15%) or formalin (5%) was subcutaneously injected bilaterally into the hind paws (100μL per each paw) of adult male c-fos-eGFP transgenic or wild-type rats.
    Summary · context
    Control rats were injected with ethanol or physiological saline respectively.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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