Impact of high-dose vitamin D₃ on plasma free 25-hydroxyvitamin D concentrations and antimicrobial peptides in critically ill mechanically ventilated adults.

Han JE, Alvarez JA, Jones JL, Tangpricha V, Brown MA, Hao L, Brown LAS, Martin GS, Ziegler TR

Nutrition (Burbank, Los Angeles County, Calif.)27 Feb 2017Cited by 23 (Europe PMC)

PMID28526374PMCIDPMC5439302DOI10.1016/j.nut.2017.02.002PepBankPUB-28526374

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelRandomized controlled trialOther
In critically ill ventilated adults, plasma levels of the body's own LL‑37 correlated with the percentage of alveolar macrophages that showed phagocytosis.
In plain wordsIn critically ill adults, higher natural LL‑37 levels in blood were linked to more active lung immune cells.
Peptide
LL-37
Outcome
Not applicablePlasma LL-37 versus alveolar macrophage phagocytosis
Study
n: not reported in source
Outcome group
Immune response · Immune and inflammation
Measurements
Spearman correlation
0.51 rho
plasma LL-37 vs macrophage phagocytosis
Source sentences
Summary
Additionally, plasma LL-37 levels correlated with the percentage of alveolar macrophages exhibiting phagocytosis (ρ = 0.51; P = 0.04).
1 context sentence(design, population, supporting numbers)
Summary · context
In a double blind, randomized controlled trial, critically ill ventilator-dependent adults (N = 30) received enteral vitamin D₃ (250,000 or 500,000 IU total over 5 d) or placebo.
This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2852637401
02HumanEndogenous levelRandomized controlled trialOther
In critically ill ventilated adults given high-dose vitamin D3, changes in total and free 25(OH)D did not correlate with plasma levels of the body's own LL‑37.
In plain wordsIn critically ill adults given vitamin D, vitamin D level changes were not linked to changes in the body's own LL‑37.
Peptide
LL-37
Outcome
No significant changeChange in free and total 25(OH)D versus plasma LL-37
Study
n: not reported in source
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
There were no correlations between changes in total and free 25(OH)D against plasma LL-37 and hBD-2 concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
In a double blind, randomized controlled trial, critically ill ventilator-dependent adults (N = 30) received enteral vitamin D₃ (250,000 or 500,000 IU total over 5 d) or placebo.
This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2852637402
03HumanEndogenous levelRandomized controlled trialOther
In critically ill ventilated adults given high-dose vitamin D3, the percent change in blood cell mRNA of hCAP18, the precursor of LL‑37, was positively associated with the percent change in free 25(OH)D at days 7 and 14.
In plain wordsIn critically ill adults given vitamin D, free vitamin D rises were linked to rises in the body's own LL‑37 precursor gene signal.
Peptide
LL-37
Outcome
Not applicablehCAP18 mRNA expression versus free 25(OH)D change
Study
n: not reported in source
Outcome group
Immune response · Immune and inflammation
Measurements
Spearman correlation
0.48 rho
day 7
Spearman correlation
0.59 rho
day 14
Source sentences
Summary
The percent change in mRNA expression of hCAP18 was positively associated with percent change in free 25(OH)D at days 7 and 14 (ρ = 0.48; P = 0.04 and ρ = 0.59; P = 0.03, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
In a double blind, randomized controlled trial, critically ill ventilator-dependent adults (N = 30) received enteral vitamin D₃ (250,000 or 500,000 IU total over 5 d) or placebo.
This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2852637403

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:57 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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