Skip to content

Study · Animal study (in vivo) · macaca mulatta · 2015

5 results

[Correction of impaired glucose tolerance using tetrapeptide (Pancragen) in old female rhesus monkeys].

Goncharova ND, Ivanova LG, Oganyan TE, Vengerin AA, Khavinson VK

Advances in gerontology = Uspekhi gerontologii1 Jan 2015

PMID28509500 (opens in a new tab)PepBankPUB-28509500
Publisher pageAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In old female rhesus monkeys, Pancragen lowered blood glucose less than glimepiride.

    In plain wordsIn rhesus monkeys, Pancragen lowered blood glucose less than glimepiride in old females.

    Peptide
    Pancragen (KEDW)
    Outcome
    IncreaseBlood glucose relative to glimepiride
    Study

    Macaca mulattan = 9

    old clinically healthy female rhesus monkeys
    Comparator
    glimepiride
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0,05 mg/animal per day · intramuscularly · 10 daysAs given in this study (Macaca mulatta).

    Source sentences

    Summary
    At the same time, glimepiride administration led to a more expressed and delayed hypoglycemic effect
    3 context sentences
    Summary · context
    Pancragen and glimepiride administration induced the decrease of blood glucose basal levels in both groups of old monkeys.
    Summary · context
    The investigation involved 9 old (20-25 years) clinically healthy rhesus monkey females (Macaca mulatta).
    Summary · context
    Five of them were injected with Pancragen (0,05 mg/animal per day during 10 days, intramuscularly) for 10 days
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In old female rhesus monkeys, glimepiride produced a more delayed hypoglycemic effect than Pancragen.

    In plain wordsIn rhesus monkeys, Pancragen's blood glucose effect occurred earlier than glimepiride's in old females.

    Peptide
    Pancragen (KEDW)
    Outcome
    Not applicableTiming of hypoglycemic effect relative to glimepiride
    Study

    Macaca mulattan = 9

    old clinically healthy female rhesus monkeys
    Comparator
    glimepiride
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0,05 mg/animal per day · intramuscularly · 10 daysAs given in this study (Macaca mulatta).

    Source sentences

    Summary
    At the same time, glimepiride administration led to a more expressed and delayed hypoglycemic effect
    3 context sentences
    Summary · context
    Pancragen and glimepiride administration induced the decrease of blood glucose basal levels in both groups of old monkeys.
    Summary · context
    The investigation involved 9 old (20-25 years) clinically healthy rhesus monkey females (Macaca mulatta).
    Summary · context
    Five of them were injected with Pancragen (0,05 mg/animal per day during 10 days, intramuscularly) for 10 days
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In old female rhesus monkeys, Pancragen decreased basal blood glucose from pretreatment levels.

    In plain wordsIn rhesus monkeys, Pancragen lowered basal blood glucose from pretreatment levels in old females.

    Peptide
    Pancragen (KEDW)
    Outcome
    DecreaseBasal blood glucose
    Study

    Macaca mulattan = 5

    old clinically healthy female rhesus monkeys
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0,05 mg/animal per day · intramuscularly · 10 daysAs given in this study (Macaca mulatta).

    Source sentences

    Summary
    Pancragen and glimepiride administration induced the decrease of blood glucose basal levels in both groups of old monkeys.
    2 context sentences
    Summary · context
    The investigation involved 9 old (20-25 years) clinically healthy rhesus monkey females (Macaca mulatta).
    Summary · context
    Five of them were injected with Pancragen (0,05 mg/animal per day during 10 days, intramuscularly) for 10 days
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In old female rhesus monkeys, Pancragen normalized insulin levels.

    In plain wordsIn rhesus monkeys, Pancragen normalized insulin levels in old females.

    Peptide
    Pancragen (KEDW)
    Outcome
    Direction not reportedInsulin levels
    Study

    Macaca mulattan = 5

    old clinically healthy female rhesus monkeys
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0,05 mg/animal per day · intramuscularly · 10 daysAs given in this study (Macaca mulatta).

    Source sentences

    Summary
    Pancragen also normalized insulin and C peptide levels suggesting its recovering effect on the disturbed tolerance to glucose in old animals.
    2 context sentences
    Summary · context
    The investigation involved 9 old (20-25 years) clinically healthy rhesus monkey females (Macaca mulatta).
    Summary · context
    Five of them were injected with Pancragen (0,05 mg/animal per day during 10 days, intramuscularly) for 10 days
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In old female rhesus monkeys, Pancragen normalized C peptide levels.

    In plain wordsIn rhesus monkeys, Pancragen normalized C peptide levels in old females.

    Peptide
    Pancragen (KEDW)
    Outcome
    Direction not reportedC peptide levels
    Study

    Macaca mulattan = 5

    old clinically healthy female rhesus monkeys
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0,05 mg/animal per day · intramuscularly · 10 daysAs given in this study (Macaca mulatta).

    Source sentences

    Summary
    Pancragen also normalized insulin and C peptide levels suggesting its recovering effect on the disturbed tolerance to glucose in old animals.
    2 context sentences
    Summary · context
    The investigation involved 9 old (20-25 years) clinically healthy rhesus monkey females (Macaca mulatta).
    Summary · context
    Five of them were injected with Pancragen (0,05 mg/animal per day during 10 days, intramuscularly) for 10 days

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 17:05 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.