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Study · Not a test of the peptide alone · 2017

4 results

A new adenovector system for implementing thymulin gene therapy for inflammatory disorders.

Zappa-Villar MF, López-León M, Pardo J, Costa M, Crespo R, Dardenne M, Goya RG, Reggiani PC

Molecular immunology11 May 2017

PMID28501652 (opens in a new tab)DOI10.1016/j.molimm.2017.04.014 (opens in a new tab)PepBankPUB-28501652
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 01AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Activity measurement

    In rats, intracerebroventricular ETV injection significantly increased cerebrospinal fluid thymulin levels.

    In plain wordsIn rats, thymulin gene therapy increased thymulin levels in cerebrospinal fluid.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseCerebrospinal fluid thymulin levels
    Study

    ratn: not reported in source

    Thymulin adenovector gene transfer
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    After intracerebroventricular injection of ETV in rats, thymulin levels increased significantly in the cerebrospinal fluid and there was high hGFP expression in the ependymal cell layer.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 02AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Activity measurement

    In the animal gene-transfer study, intramuscular ETV injection progressively increased serum thymulin levels.

    In plain wordsIn animals, intramuscular thymulin gene therapy progressively increased blood thymulin levels.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseSerum thymulin levels after ETV
    Study

    n: not reported in source

    Thymulin adenovector gene transfer
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    When injected intramuscularly the ETV system induced a progressive increase in serum thymulin levels, which were inhibited when DOX was added to the drinking water.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  3. 03AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Mechanism

    In the animal gene-transfer study, doxycycline in drinking water inhibited the ETV-induced increase in serum thymulin levels.

    In plain wordsIn animals, doxycycline in drinking water inhibited the increase in blood thymulin after gene therapy.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseDoxycycline inhibition of serum thymulin increase
    Study

    n: not reported in source

    Thymulin adenovector gene transfer
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    When injected intramuscularly the ETV system induced a progressive increase in serum thymulin levels, which were inhibited when DOX was added to the drinking water.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  4. 04LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Mechanism

    In CHO-K1 cells, doxycycline at 1mg/ml almost completely inhibited transgene expression from the vector system.

    In plain wordsIn cells, doxycycline almost completely inhibited expression from the gene therapy vector.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseDoxycycline inhibition of transgene expression
    Study

    n: not reported in source

    CHO-K1 cells
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    In CHO-K1 cells, transgene expression was almost completely inhibited by DOX (1mg/ml).
    1 context sentence
    Summary · context
    The experimental two-vector system, ETV, consists of a recombinant adenovector (RAd) harboring an expression cassette centered on a Tet-Off bidirectional promoter flanked by a synthetic gene for thymulin and the gene for humanized Green Fluorescent Protein (hGFP).

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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