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Study · Animal study (in vivo) · rat · 2017

4 results

B7-33 replicates the vasoprotective functions of human relaxin-2 (serelaxin).

Marshall SA, O'Sullivan K, Ng HH, Bathgate RAD, Parry LJ, Hossain MA, Leo CH

European journal of pharmacology3 May 2017Cited by 29 (Europe PMC)

PMID28478069 (opens in a new tab)DOI10.1016/j.ejphar.2017.05.005 (opens in a new tab)PepBankPUB-28478069
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats, B7‑33 enhanced bradykinin-mediated mesenteric artery relaxation versus placebo by increasing endothelium-derived hyperpolarization.

    In plain wordsIn rats, B7‑33 increased bradykinin-mediated mesenteric artery relaxation compared with placebo through increased endothelium-derived hyperpolarization.

    Peptide
    B7-33 (single-chain relaxin-2 analog)
    Outcome
    IncreaseMesenteric artery bradykinin-mediated relaxation
    Study

    ratn: not reported in source

    Male Wistar rats
    Comparator
    Placebo (20mM sodium acetate)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    13.3μg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    B7-33 and serelaxin selectively enhanced bradykinin-mediated endothelium-dependent relaxation in the rat mesenteric artery by increasing endothelium-derived hyperpolarization, but had no overall effects on relaxation in the small renal artery or aorta.
    2 context sentences
    Summary · context
    Male Wistar rats received a tail vein injection of placebo (20mM sodium acetate), B7-33 (13.3μg/kg) or serelaxin (26.6μg/kg).
    Summary · context
    Three hours later vascular function in the mesenteric artery, small renal artery and abdominal aorta was assessed by wire myography.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats, B7‑33 had no overall effect on small renal artery relaxation versus placebo.

    In plain wordsIn rats, B7‑33 did not change overall small renal artery relaxation compared with placebo.

    Peptide
    B7-33 (single-chain relaxin-2 analog)
    Outcome
    No significant changeSmall renal artery relaxation
    Study

    ratn: not reported in source

    Male Wistar rats
    Comparator
    Placebo (20mM sodium acetate)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    13.3μg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    B7-33 and serelaxin selectively enhanced bradykinin-mediated endothelium-dependent relaxation in the rat mesenteric artery by increasing endothelium-derived hyperpolarization, but had no overall effects on relaxation in the small renal artery or aorta.
    2 context sentences
    Summary · context
    Male Wistar rats received a tail vein injection of placebo (20mM sodium acetate), B7-33 (13.3μg/kg) or serelaxin (26.6μg/kg).
    Summary · context
    Three hours later vascular function in the mesenteric artery, small renal artery and abdominal aorta was assessed by wire myography.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male Wistar rats, B7‑33 had no overall effect on aortic relaxation versus placebo.

    In plain wordsIn rats, B7‑33 did not change overall aortic relaxation compared with placebo.

    Peptide
    B7-33 (single-chain relaxin-2 analog)
    Outcome
    No significant changeAortic relaxation
    Study

    ratn: not reported in source

    Male Wistar rats
    Comparator
    Placebo (20mM sodium acetate)
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    13.3μg/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    B7-33 and serelaxin selectively enhanced bradykinin-mediated endothelium-dependent relaxation in the rat mesenteric artery by increasing endothelium-derived hyperpolarization, but had no overall effects on relaxation in the small renal artery or aorta.
    2 context sentences
    Summary · context
    Male Wistar rats received a tail vein injection of placebo (20mM sodium acetate), B7-33 (13.3μg/kg) or serelaxin (26.6μg/kg).
    Summary · context
    Three hours later vascular function in the mesenteric artery, small renal artery and abdominal aorta was assessed by wire myography.
  4. 04LabEx vivo tissueEfficacy outcome

    In isolated mouse mesenteric arteries, B7‑33 prevented endothelial dysfunction induced by trophoblast conditioned media.

    In plain wordsIn lab tests on mouse arteries, B7‑33 prevented endothelial dysfunction induced by trophoblast conditioned media.

    Peptide
    B7-33 (single-chain relaxin-2 analog)
    Outcome
    DecreaseEndothelial dysfunction
    Study

    mousen: not reported in source

    Virgin female mouse mesenteric arteries in placental trophoblast conditioned media
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    15, 30nMAs given in this study (mouse).

    Source sentences

    Summary
    Co-incubation of these arteries in trophoblast conditioned media with B7-33 or serelaxin (15, 30nM) prevented the development of endothelial dysfunction.
    1 context sentence
    Summary · context
    We then compared the actions of B7-33 and serelaxin in an ex vivo model of vascular disease using virgin female mouse mesenteric arteries pre-incubated in placental trophoblast conditioned media to induce endothelial dysfunction characteristic of preeclampsia.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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