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Study · Systematic review · 2017

5 results

Meta-analysis of the effects of intranasal oxytocin on interpretation and expression of emotions.

Leppanen J, Ng KW, Tchanturia K, Treasure J

Neuroscience and biobehavioral reviews30 Apr 2017Cited by 141 (Europe PMC)

PMID28467893 (opens in a new tab)DOI10.1016/j.neubiorev.2017.04.010 (opens in a new tab)PepBankPUB-28467893
Source linkPubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In healthy individuals, a single dose of intranasal oxytocin significantly improved the recognition of basic emotions, particularly fear.

    In plain wordsIn healthy people, one dose of intranasal oxytocin improved recognition of basic emotions, especially fear.

    Peptide
    Oxytocin
    Outcome
    IncreaseRecognition of basic emotions
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    single dose · intranasalAs given in this study (human).

    Source sentences

    Summary
    A single dose of intranasal oxytocin significantly improved the recognition of basic emotions, particularly fear, and increased the expression of positive emotions among the healthy individuals.
    1 context sentence
    Summary · context
    This review consists of 33 studies.
  2. 02HumanSystematic reviewEfficacy outcome

    In healthy individuals, a single dose of intranasal oxytocin significantly increased the expression of positive emotions.

    In plain wordsIn healthy people, one dose of intranasal oxytocin increased the expression of positive emotions.

    Peptide
    Oxytocin
    Outcome
    IncreaseExpression of positive emotions
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    single dose · intranasalAs given in this study (human).

    Source sentences

    Summary
    A single dose of intranasal oxytocin significantly improved the recognition of basic emotions, particularly fear, and increased the expression of positive emotions among the healthy individuals.
    1 context sentence
    Summary · context
    This review consists of 33 studies.
  3. 03HumanSystematic reviewEfficacy outcome

    In healthy individuals, intranasal oxytocin did not significantly influence theory of mind.

    In plain wordsIn healthy people, intranasal oxytocin did not significantly change the ability to understand what others think or feel.

    Peptide
    Oxytocin
    Outcome
    No significant changeEmotional theory of mind
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    single dose · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin did not significantly influence theory of mind or the expression of negative emotions among the healthy individuals.
    1 context sentence
    Summary · context
    This review consists of 33 studies.
  4. 04HumanSystematic reviewEfficacy outcome

    In healthy individuals, intranasal oxytocin did not significantly influence the expression of negative emotions.

    In plain wordsIn healthy people, intranasal oxytocin did not significantly change the expression of negative emotions.

    Peptide
    Oxytocin
    Outcome
    No significant changeExpression of negative emotions
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    single dose · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin did not significantly influence theory of mind or the expression of negative emotions among the healthy individuals.
    1 context sentence
    Summary · context
    This review consists of 33 studies.
  5. 05HumanSystematic reviewEfficacy outcome

    In clinical populations, intranasal oxytocin did not significantly influence the interpretation or expression of emotions.

    In plain wordsIn people with mental health conditions, intranasal oxytocin did not significantly change how they interpreted or expressed emotions.

    Peptide
    Oxytocin
    Outcome
    No significant changeInterpretation and expression of emotions in clinical populations
    Study

    n: not reported in source

    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    single dose · intranasalAs given in this study (human).

    Source sentences

    Summary
    Finally, intranasal oxytocin did not significantly influence interpretation or expression of emotions among the clinical populations.
    1 context sentence
    Summary · context
    This review consists of 33 studies.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 2NCT06945926

The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery

Zhejiang Universityn = 2271 Jun 2025 to 2 Jun 2026

Cervical Spinal Stenosis · Thoracic Spinal Stenosis · Lumbar Spinal Stenosis · Rotator Cuff Injury · Femoral Head Necrosis · Spinal Trauma · Knee Joint Injury

Trial pageClinicalTrials.govUpdated 20 Aug 2026

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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