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Study · Not a test of the peptide alone · 2017

3 results

Expression and Purification of Delta Sleep-Inducing Peptide Fused with Protein Transduction Domain and Human Serum Albumin in Pichia pastoris.

Zhang XG, Wang WN, Zhang CS, Li K, Ma GD, Li JY

Protein and peptide letters1 Jan 2017Cited by 1 (Europe PMC)

PMID28462721 (opens in a new tab)DOI10.2174/0929866524666170426113022 (opens in a new tab)PepBankPUB-28462721
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 01AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome

    In mice, the PHD fusion protein (TAT, albumin and DSIP) reduced pentobarbital-induced sleep latency as concentration increased.

    In plain wordsIn mice, a DSIP fusion protein shortened the time to fall asleep after pentobarbital, more at higher doses.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseSleep latency
    Study

    mousen: not reported in source

    Pentobarbital-induced sleep test
    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    the increase of pentobarbital-induced hypnotic effect characterized by reducing sleep latency and prolonged sleep duration was observed for increasing concentrations of PHD fusion protein (P<0.05)
    1 context sentence
    Summary · context
    Mice were administered single subcutaneous injections three concentrations of PHD fusion protein (0.5, 1, 2 mg/kg), and the pharmacological activity of PHD fusion protein was studied using classic pentobarbitalinduced sleep test.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  2. 02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome

    In mice, the PHD fusion protein (TAT, albumin and DSIP) prolonged pentobarbital-induced sleep duration as concentration increased.

    In plain wordsIn mice, a DSIP fusion protein lengthened sleep after pentobarbital, more at higher doses.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSleep duration
    Study

    mousen: not reported in source

    Pentobarbital-induced sleep test
    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    the increase of pentobarbital-induced hypnotic effect characterized by reducing sleep latency and prolonged sleep duration was observed for increasing concentrations of PHD fusion protein (P<0.05)
    1 context sentence
    Summary · context
    Mice were administered single subcutaneous injections three concentrations of PHD fusion protein (0.5, 1, 2 mg/kg), and the pharmacological activity of PHD fusion protein was studied using classic pentobarbitalinduced sleep test.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  3. 03AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Efficacy outcome

    In mice, the PHD fusion protein at 1.0 and 2.0 mg/kg significantly increased the rate of sleep re-onset compared with vehicle.

    In plain wordsIn mice, higher doses of a DSIP fusion protein made more animals fall asleep again than vehicle did.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSleep re-onset rate
    Study

    mousen: not reported in source

    Pentobarbital-induced sleep test
    Comparator
    Vehicle
    Outcome group
    Sleep · Sleep

    Source sentences

    Summary
    different dose of PHD fusion protein could induce the mice to re-sleep in a dose-dependent manner, whereas higher doses of PHD fusion protein (1.0, 2.0 mg/kg) significantly increased the rate of sleep re-onset compared with the vehicle group of mice (P<0.05).
    1 context sentence
    Summary · context
    Mice were administered single subcutaneous injections three concentrations of PHD fusion protein (0.5, 1, 2 mg/kg), and the pharmacological activity of PHD fusion protein was studied using classic pentobarbitalinduced sleep test.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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