Cerebrolysin alleviates cognitive deficits induced by chronic cerebral hypoperfusion by increasing the levels of plasticity-related proteins and decreasing the levels of apoptosis-related proteins in the rat hippocampus.

Liu Z, Hu M, Lu P, Wang H, Qi Q, Xu J, Xiao Y, Fan M, Jia Y, Zhang D

Neuroscience letters27 Apr 2017Cited by 33 (Europe PMC)

PMID28458021DOI10.1016/j.neulet.2017.04.022PepBankPUB-28458021

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats after carotid artery occlusion, Cerebrolysin significantly decreased Morris water maze escape latency.
In plain wordsIn rats, Cerebrolysin reduced the time needed to escape in a water maze.
Peptide
Cerebrolysin
Outcome
DecreaseEscape latency
Study
ratn: not reported in source
Adult male Sprague-Dawley rats after bilateral common carotid artery occlusion
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
2.5ml/kg or 5ml/kg · 28 daysAs given in this study (rat).
Source sentences
Summary
The CBL treatment significantly decreased the escape latency and increased the percentage of time the rat spent in the target quadrant of the Morris water maze (MWM) task.
3 context sentences(design, population, supporting numbers)
Summary · context
In our study, adult male Sprague-Dawley rats were subjected to bilateral common carotid artery occlusion (BCCAO) surgery.
Summary · context
The animals were randomly divided into four groups after the operation: Sham, Vehicle, L-CBL (2.5ml/kg), and H-CBL (5ml/kg).
Summary · context
CBL was administered after the operation daily for 28 days.
Report a problemFND-2845802101
02AnimalAnimal study (in vivo)Efficacy outcome
In rats after carotid artery occlusion, Cerebrolysin increased the percentage of time in the water maze target quadrant.
In plain wordsIn rats, Cerebrolysin increased time in the target area of a water maze.
Peptide
Cerebrolysin
Outcome
IncreaseTime in target quadrant
Study
ratn: not reported in source
Adult male Sprague-Dawley rats after bilateral common carotid artery occlusion
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
2.5ml/kg or 5ml/kg · 28 daysAs given in this study (rat).
Source sentences
Summary
The CBL treatment significantly decreased the escape latency and increased the percentage of time the rat spent in the target quadrant of the Morris water maze (MWM) task.
3 context sentences(design, population, supporting numbers)
Summary · context
In our study, adult male Sprague-Dawley rats were subjected to bilateral common carotid artery occlusion (BCCAO) surgery.
Summary · context
The animals were randomly divided into four groups after the operation: Sham, Vehicle, L-CBL (2.5ml/kg), and H-CBL (5ml/kg).
Summary · context
CBL was administered after the operation daily for 28 days.
Report a problemFND-2845802102
03AnimalAnimal study (in vivo)Mechanism
In rats after carotid artery occlusion, Cerebrolysin significantly increased hippocampal PSD-95 expression.
In plain wordsIn rats, Cerebrolysin increased a hippocampal protein involved in synaptic plasticity, PSD-95.
Peptide
Cerebrolysin
Outcome
IncreasePSD-95 expression
Study
ratn: not reported in source
Adult male Sprague-Dawley rats after bilateral common carotid artery occlusion
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
2.5ml/kg or 5ml/kg · 28 daysAs given in this study (rat).
Source sentences
Summary
Furthermore, CBL significantly increased the expression of plasticity-related synaptic proteins, such as postsynaptic density protein 95 (PSD-95), protein kinase C subunit gamma (PKCγ), phosphorylated cAMP response element binding protein (p-CREB), and decreased the expression of apoptosis-related p…
3 context sentences(design, population, supporting numbers)
Summary · context
In our study, adult male Sprague-Dawley rats were subjected to bilateral common carotid artery occlusion (BCCAO) surgery.
Summary · context
The animals were randomly divided into four groups after the operation: Sham, Vehicle, L-CBL (2.5ml/kg), and H-CBL (5ml/kg).
Summary · context
CBL was administered after the operation daily for 28 days.
Report a problemFND-2845802103
04AnimalAnimal study (in vivo)Mechanism
In rats after carotid artery occlusion, Cerebrolysin significantly increased hippocampal PKCγ expression.
In plain wordsIn rats, Cerebrolysin increased a hippocampal protein involved in synaptic plasticity, PKCγ.
Peptide
Cerebrolysin
Outcome
IncreasePKCγ expression
Study
ratn: not reported in source
Adult male Sprague-Dawley rats after bilateral common carotid artery occlusion
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
2.5ml/kg or 5ml/kg · 28 daysAs given in this study (rat).
Source sentences
Summary
Furthermore, CBL significantly increased the expression of plasticity-related synaptic proteins, such as postsynaptic density protein 95 (PSD-95), protein kinase C subunit gamma (PKCγ), phosphorylated cAMP response element binding protein (p-CREB), and decreased the expression of apoptosis-related p…
3 context sentences(design, population, supporting numbers)
Summary · context
In our study, adult male Sprague-Dawley rats were subjected to bilateral common carotid artery occlusion (BCCAO) surgery.
Summary · context
The animals were randomly divided into four groups after the operation: Sham, Vehicle, L-CBL (2.5ml/kg), and H-CBL (5ml/kg).
Summary · context
CBL was administered after the operation daily for 28 days.
Report a problemFND-2845802104
05AnimalAnimal study (in vivo)Mechanism
In rats after carotid artery occlusion, Cerebrolysin significantly increased hippocampal p-CREB expression.
In plain wordsIn rats, Cerebrolysin increased a hippocampal protein involved in synaptic plasticity, p-CREB.
Peptide
Cerebrolysin
Outcome
Increasep-CREB expression
Study
ratn: not reported in source
Adult male Sprague-Dawley rats after bilateral common carotid artery occlusion
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
2.5ml/kg or 5ml/kg · 28 daysAs given in this study (rat).
Source sentences
Summary
Furthermore, CBL significantly increased the expression of plasticity-related synaptic proteins, such as postsynaptic density protein 95 (PSD-95), protein kinase C subunit gamma (PKCγ), phosphorylated cAMP response element binding protein (p-CREB), and decreased the expression of apoptosis-related p…
3 context sentences(design, population, supporting numbers)
Summary · context
In our study, adult male Sprague-Dawley rats were subjected to bilateral common carotid artery occlusion (BCCAO) surgery.
Summary · context
The animals were randomly divided into four groups after the operation: Sham, Vehicle, L-CBL (2.5ml/kg), and H-CBL (5ml/kg).
Summary · context
CBL was administered after the operation daily for 28 days.
Report a problemFND-2845802105
06AnimalAnimal study (in vivo)Mechanism
In rats after carotid artery occlusion, Cerebrolysin decreased hippocampal expression of apoptosis-related proteins.
In plain wordsIn rats, Cerebrolysin reduced hippocampal proteins associated with cell death.
Peptide
Cerebrolysin
Outcome
DecreaseApoptosis-related protein expression
Study
ratn: not reported in source
Adult male Sprague-Dawley rats after bilateral common carotid artery occlusion
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
2.5ml/kg or 5ml/kg · 28 daysAs given in this study (rat).
Source sentences
Summary
Furthermore, CBL significantly increased the expression of plasticity-related synaptic proteins, such as postsynaptic density protein 95 (PSD-95), protein kinase C subunit gamma (PKCγ), phosphorylated cAMP response element binding protein (p-CREB), and decreased the expression of apoptosis-related p…
3 context sentences(design, population, supporting numbers)
Summary · context
In our study, adult male Sprague-Dawley rats were subjected to bilateral common carotid artery occlusion (BCCAO) surgery.
Summary · context
The animals were randomly divided into four groups after the operation: Sham, Vehicle, L-CBL (2.5ml/kg), and H-CBL (5ml/kg).
Summary · context
CBL was administered after the operation daily for 28 days.
Report a problemFND-2845802106

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 ongoing · source ClinicalTrials.gov (opens in a new tab)

Enrolling by invitationNot applicableNCT06677502

Cerebrolysin in Critically Ill Patients With Delirium

Medical University of Lublinn = 5001 Jan 2024 to est. 31 Dec 2025

Cognitive Impairment

Trial page ClinicalTrials.govUpdated 31 Dec 2024

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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