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Study · In vitro (cells) · escherichia coli · 2017

4 results

Action of Antimicrobial Peptides on Bacterial and Lipid Membranes: A Direct Comparison.

Faust JE, Yang PY, Huang HW

Biophysical journal1 Apr 2017Cited by 49 (Europe PMC)

PMID28445757 (opens in a new tab)PMCIDPMC5406281 (opens in a new tab)DOI10.1016/j.bpj.2017.03.003 (opens in a new tab)PepBankPUB-28445757
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In E. coli spheroplasts, LL37 reproduced the sigmoidal rise to a steady state in intracellular fluorescence intensity that shows membrane permeabilization, as melittin and alamethicin did.

    In plain wordsIn lab tests on bacterial cells, LL37 made the bacterial membrane leaky in the same pattern as melittin and alamethicin.

    Peptide
    LL-37
    Outcome
    IncreaseMembrane permeabilization pattern in E. coli spheroplasts
    Study

    Escherichia colin: not reported in source

    E. coli spheroplasts
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This regular pattern is reproducible by melittin, LL37, and alamethicin but not by CCCP or daptomycin, agents known to cause ion leakage.
    1 context sentence
    Summary · context
    AMPs induce membrane permeability in E. coli spheroplasts or giant unilamellar vesicles (GUVs) under well-defined concentrations of AMPs and fluorescent molecules.

Studies that did not test the peptide alone3

In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking LL-37.

  1. 02LabNot a test of LL-37 aloneIn vitro (cells)Activity measurement

    In E. coli spheroplasts and giant unilamellar vesicles, pooled antimicrobial peptides induced quantitatively the same steady-state membrane permeability.

    In plain wordsIn lab tests, a group of antimicrobial peptides made bacterial cells and artificial vesicles equally leaky at steady state.

    Peptide
    LL-37
    Outcome
    No significant changeSteady-state membrane permeability in spheroplasts versus GUVs (pooled AMPs)
    Study

    Escherichia colin: not reported in source

    E. coli spheroplasts and giant unilamellar vesicles
    Outcome group
    Infection and antimicrobial activity · Infection

    Source sentences

    Summary
    Indeed the steady-state membrane permeability induced by AMPs is quantitatively the same in spheroplasts and GUVs.
    1 context sentence
    Summary · context
    AMPs induce membrane permeability in E. coli spheroplasts or giant unilamellar vesicles (GUVs) under well-defined concentrations of AMPs and fluorescent molecules.

    In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.

  2. 03LabNot a test of LL-37 aloneIn vitro (cells)Activity measurement

    In E. coli spheroplasts, pooled antimicrobial peptides permeabilized membranes to the same steady-state permeability over a wide range of concentrations.

    In plain wordsIn lab tests, a group of antimicrobial peptides made bacterial cell membranes equally leaky across a wide range of doses.

    Peptide
    LL-37
    Outcome
    Not applicableAMP concentration range giving steady-state permeability in spheroplasts (pooled AMPs)
    Study

    Escherichia colin: not reported in source

    E. coli spheroplasts
    Outcome group
    Infection and antimicrobial activity · Infection

    Source sentences

    Summary
    Spheroplast membranes are permeabilized by a wide range of AMP concentrations to the same steady-state membrane permeability.
    1 context sentence
    Summary · context
    AMPs induce membrane permeability in E. coli spheroplasts or giant unilamellar vesicles (GUVs) under well-defined concentrations of AMPs and fluorescent molecules.

    In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.

  3. 04LabNot a test of LL-37 aloneIn vitro (cell-free)Activity measurement

    In giant unilamellar vesicles, only a narrow range of pooled antimicrobial peptide concentrations permeabilized membranes to a steady state.

    In plain wordsIn lab tests, a group of antimicrobial peptides made artificial vesicles leaky at steady state only within a narrow dose range.

    Peptide
    LL-37
    Outcome
    Not applicableAMP concentration range giving steady-state permeability in GUVs (pooled AMPs)
    Study

    n: not reported in source

    Giant unilamellar vesicles
    Outcome group
    Infection and antimicrobial activity · Infection

    Source sentences

    Summary
    In contrast, only a narrow range of AMP concentrations permeabilized GUVs to a steady state.
    1 context sentence
    Summary · context
    AMPs induce membrane permeability in E. coli spheroplasts or giant unilamellar vesicles (GUVs) under well-defined concentrations of AMPs and fluorescent molecules.

    In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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