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Study · Systematic review · 2017

5 results

The correlation between central and peripheral oxytocin concentrations: A systematic review and meta-analysis.

Valstad M, Alvares GA, Egknud M, Matziorinis AM, Andreassen OA, Westlye LT, Quintana DS

Neuroscience and biobehavioral reviews23 Apr 2017Cited by 212 (Europe PMC)

PMID28442403 (opens in a new tab)DOI10.1016/j.neubiorev.2017.04.017 (opens in a new tab)PepBankPUB-28442403
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanSystematic reviewPharmacokinetics

    In a meta-analysis, central and peripheral oxytocin concentrations were significantly and positively correlated after intranasal oxytocin administration.

    In plain wordsAfter people were given oxytocin by nose spray, oxytocin levels in blood and in the brain fluid rose and fell together.

    Peptide
    Oxytocin
    Outcome
    IncreaseCorrelation between central and peripheral oxytocin after intranasal administration
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intranasalAs given in this study.

    Measurements

    correlation r
    0.66 r
    central vs peripheral oxytocin, after intranasal oxytocin

    Source sentences

    Summary
    significant associations were observed after intranasal oxytocin administration (r=0.66, p<0.0001)
    1 context sentence
    Summary · context
    A search of databases yielded 17 eligible studies, resulting in a total sample size of 516 participants and subjects.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02HumanEndogenous levelSystematic reviewOther

    In a meta-analysis of 17 studies, the body's own central and peripheral oxytocin concentrations were positively correlated overall.

    In plain wordsAcross 17 studies, the body's own oxytocin levels in blood and in the brain fluid were positively linked overall.

    Peptide
    Oxytocin
    Outcome
    IncreaseCorrelation between central and peripheral oxytocin concentrations (overall)
    Study

    n = 516

    Outcome group
    Hormone levels · Endocrine and hormones

    Measurements

    correlation r
    0.29 r
    central vs peripheral oxytocin, overall

    Source sentences

    Summary
    Overall, a positive association between central and peripheral oxytocin concentrations was revealed [r=0.29, 95% CI (0.14, 0.42), p<0.0001].
    1 context sentence
    Summary · context
    A search of databases yielded 17 eligible studies, resulting in a total sample size of 516 participants and subjects.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 03HumanEndogenous levelSystematic reviewOther

    In a meta-analysis, the body's own central and peripheral oxytocin concentrations were not significantly correlated under basal conditions.

    In plain wordsAt rest, the body's own oxytocin levels in blood did not track its levels in the brain fluid.

    Peptide
    Oxytocin
    Outcome
    No significant changeCorrelation between central and peripheral oxytocin under basal conditions
    Study

    n: not reported in source

    Outcome group
    Hormone levels · Endocrine and hormones

    Measurements

    correlation r
    0.08 r
    central vs peripheral oxytocin, basal conditions

    Source sentences

    Summary
    While no association was observed under basal conditions (r=0.08, p=0.31
    1 context sentence
    Summary · context
    A search of databases yielded 17 eligible studies, resulting in a total sample size of 516 participants and subjects.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 04HumanEndogenous levelSystematic reviewOther

    In a meta-analysis, the body's own central and peripheral oxytocin concentrations were significantly and positively correlated after experimentally induced stress.

    In plain wordsAfter induced stress, the body's own oxytocin levels in blood and in the brain fluid rose and fell together.

    Peptide
    Oxytocin
    Outcome
    IncreaseCorrelation between central and peripheral oxytocin after experimentally induced stress
    Study

    n: not reported in source

    Outcome group
    Hormone levels · Endocrine and hormones

    Measurements

    correlation r
    0.49 r
    central vs peripheral oxytocin, after induced stress

    Source sentences

    Summary
    after experimentally induced stress (r=0.49, p=0.001
    1 context sentence
    Summary · context
    A search of databases yielded 17 eligible studies, resulting in a total sample size of 516 participants and subjects.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 05HumanEndogenous levelSystematic reviewOther

    In a meta-analysis, the correlation between central and peripheral oxytocin concentrations differed by experimental context.

    In plain wordsHow closely the body's own oxytocin levels in blood and brain fluid matched depended on the situation in which they were measured.

    Peptide
    Oxytocin
    Outcome
    MixedModeration of the central-peripheral correlation by experimental context
    Study

    n: not reported in source

    Outcome group
    Hormone levels · Endocrine and hormones

    Source sentences

    Summary
    This association was moderated by experimental context [Qb(4), p=0.003].
    1 context sentence
    Summary · context
    A search of databases yielded 17 eligible studies, resulting in a total sample size of 516 participants and subjects.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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