Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacum.

Fedoreyeva LI, Dilovarova TA, Ashapkin VV, Martirosyan YT, Khavinson VK, Kharchenko PN, Vanyushin BF

Biochemistry. Biokhimiia1 Apr 2017Cited by 8 (Europe PMC)

PMID28371610DOI10.1134/s0006297917040149PepBankPUB-28371610

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In tobacco (Nicotiana tabacum) callus cultures, epitalon increased callus growth.
In plain wordsIn tobacco plant cell cultures, epitalon increased the growth of callus tissue.
Peptide
Epitalon
Outcome
IncreaseCallus growth
Study
Nicotiana tabacumn: not reported in source
tobacco callus cultures
Outcome group
Non-clinical applications · Whole body
Studied dose
10-7-10-9 MAs given in this study (Nicotiana tabacum).
Source sentences
Summary
Epitalon and bronchogen, in particular, both increase growth of calluses
1 context sentence(design, population, supporting numbers)
Summary · context
Exogenous short biologically active peptides epitalon (Ala-Glu-Asp-Gly), bronchogen (Ala-Glu-Asp-Leu), and vilon (Lys-Glu) at concentrations 10^-7-10^-9 M significantly influence growth, development, and differentiation of tobacco (Nicotiana tabacum) callus cultures.
Report a problemFND-2837161001
02LabIn vitro (cells)Efficacy outcome
In tobacco plant regenerants, epitalon stimulated the formation and growth of leaves.
In plain wordsIn tobacco plants grown from callus, epitalon stimulated leaf formation and growth.
Peptide
Epitalon
Outcome
IncreaseLeaf formation and growth in regenerants
Study
Nicotiana tabacumn: not reported in source
tobacco callus cultures
Outcome group
Non-clinical applications · Whole body
Studied dose
10-7-10-9 MAs given in this study (Nicotiana tabacum).
Source sentences
Summary
stimulate formation and growth of leaves in plant regenerants.
1 context sentence(design, population, supporting numbers)
Summary · context
Exogenous short biologically active peptides epitalon (Ala-Glu-Asp-Gly), bronchogen (Ala-Glu-Asp-Leu), and vilon (Lys-Glu) at concentrations 10^-7-10^-9 M significantly influence growth, development, and differentiation of tobacco (Nicotiana tabacum) callus cultures.
Report a problemFND-2837161002
03LabIn vitro (cells)Efficacy outcome
In tobacco cultures, bronchogen increased callus growth.
In plain wordsIn lab tests, bronchogen increased tobacco callus growth.
Peptide
Bronchogen (AEDL)
Outcome
IncreaseCallus growth
Study
Nicotiana tabacumn: not reported in source
Tobacco callus cultures and plant regenerants
Outcome group
Non-clinical applications · Whole body
Studied dose
10^-7–10^-9 MAs given in this study (Nicotiana tabacum).
Source sentences
Summary
Epitalon and bronchogen, in particular, both increase growth of calluses and stimulate formation and growth of leaves in plant regenerants.
1 context sentence(design, population, supporting numbers)
Summary · context
Exogenous short biologically active peptides epitalon (Ala-Glu-Asp-Gly), bronchogen (Ala-Glu-Asp-Leu), and vilon (Lys-Glu) at concentrations 10^-7-10^-9 M significantly influence growth, development, and differentiation of tobacco (Nicotiana tabacum) callus cultures.
Report a problemFND-2837161005
04LabIn vitro (cells)Efficacy outcome
In tobacco regenerants, bronchogen stimulated leaf formation.
In plain wordsIn lab tests, bronchogen stimulated leaf formation in tobacco regenerants.
Peptide
Bronchogen (AEDL)
Outcome
IncreaseLeaf formation
Study
Nicotiana tabacumn: not reported in source
Tobacco callus cultures and plant regenerants
Outcome group
Non-clinical applications · Whole body
Studied dose
10^-7–10^-9 MAs given in this study (Nicotiana tabacum).
Source sentences
Summary
Epitalon and bronchogen, in particular, both increase growth of calluses and stimulate formation and growth of leaves in plant regenerants.
1 context sentence(design, population, supporting numbers)
Summary · context
Exogenous short biologically active peptides epitalon (Ala-Glu-Asp-Gly), bronchogen (Ala-Glu-Asp-Leu), and vilon (Lys-Glu) at concentrations 10^-7-10^-9 M significantly influence growth, development, and differentiation of tobacco (Nicotiana tabacum) callus cultures.
Report a problemFND-2837161006
05LabIn vitro (cells)Efficacy outcome
In tobacco regenerants, bronchogen stimulated leaf growth.
In plain wordsIn lab tests, bronchogen stimulated leaf growth in tobacco regenerants.
Peptide
Bronchogen (AEDL)
Outcome
IncreaseLeaf growth
Study
Nicotiana tabacumn: not reported in source
Tobacco callus cultures and plant regenerants
Outcome group
Non-clinical applications · Whole body
Studied dose
10^-7–10^-9 MAs given in this study (Nicotiana tabacum).
Source sentences
Summary
Epitalon and bronchogen, in particular, both increase growth of calluses and stimulate formation and growth of leaves in plant regenerants.
1 context sentence(design, population, supporting numbers)
Summary · context
Exogenous short biologically active peptides epitalon (Ala-Glu-Asp-Gly), bronchogen (Ala-Glu-Asp-Leu), and vilon (Lys-Glu) at concentrations 10^-7-10^-9 M significantly influence growth, development, and differentiation of tobacco (Nicotiana tabacum) callus cultures.
Report a problemFND-2837161007

Studies that did not test the peptide alone2

In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Epitalon.

06LabNot a test of Epitalon aloneIn vitro (cells)Mechanism
In tobacco cells, the investigated peptides (epitalon, bronchogen and vilon) as a group modulated expression of genes for tissue formation and cell differentiation; the abstract gives no result for epitalon alone.
In plain wordsIn tobacco plant cells, the tested short peptides as a group changed activity of genes for tissue formation and specialization.
Peptide
Epitalon
Outcome
MixedExpression of tissue formation and differentiation genes
Study
Nicotiana tabacumn: not reported in source
tobacco callus cultures
Outcome group
Non-clinical applications · Whole body
Source sentences
Summary
The investigated peptides modulate in tobacco cells the expression of genes including genes responsible for tissue formation and cell differentiation.
1 context sentence(design, population, supporting numbers)
Summary · context
Exogenous short biologically active peptides epitalon (Ala-Glu-Asp-Gly), bronchogen (Ala-Glu-Asp-Leu), and vilon (Lys-Glu) at concentrations 10^-7-10^-9 M significantly influence growth, development, and differentiation of tobacco (Nicotiana tabacum) callus cultures.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-2837161003
07LabNot a test of Epitalon aloneIn vitro (cells)Mechanism
In tobacco cells, the investigated peptides (epitalon, bronchogen and vilon) as a group differently modulated expression of CLE, KNOX1 and GRF family genes; the abstract gives no result for epitalon alone.
In plain wordsIn tobacco plant cells, the tested short peptides as a group changed three gene families in different ways.
Peptide
Epitalon
Outcome
MixedExpression of CLE, KNOX1 and GRF family genes
Study
Nicotiana tabacumn: not reported in source
tobacco callus cultures
Outcome group
Non-clinical applications · Whole body
Source sentences
Summary
These peptides differently modulate expression of CLE family genes coding for known endogenous regulatory peptides, the KNOX1 genes (transcription factor genes) and GRF (growth regulatory factor) genes coding for respective DNA-binding proteins such as topoisomerases, nucleases, and others.
1 context sentence(design, population, supporting numbers)
Summary · context
Exogenous short biologically active peptides epitalon (Ala-Glu-Asp-Gly), bronchogen (Ala-Glu-Asp-Leu), and vilon (Lys-Glu) at concentrations 10^-7-10^-9 M significantly influence growth, development, and differentiation of tobacco (Nicotiana tabacum) callus cultures.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-2837161004

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 6 to 12Current
28 Oct 2026, 02:02 UTC
The same notice was added 7 times, first on 21 Oct 2026, 17:05 UTC. The status did not change between them.
Study results updated
Versions 3 to 5
21 Oct 2026, 16:35 UTC
The same notice was added 3 times, first on 21 Oct 2026, 16:35 UTC. The status did not change between them.
Study data updated · source update from Europe PMC
Version 2
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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