GHK-Cu-liposomes accelerate scald wound healing in mice by promoting cell proliferation and angiogenesis.

In mice with scald wounds, angiogenesis in burned skin was better with GHK‑Cu-liposomes than with free GHK‑Cu.

In plain wordsIn mice with burns, GHK‑Cu-liposomes gave better new blood vessel growth in burned skin than free GHK‑Cu.

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In mice with scald wounds, immunofluorescence showed an enhanced CD31 signal after GHK‑Cu-liposome treatment.

In plain wordsIn mice with burns, GHK‑Cu-liposomes increased a marker of blood vessel cells (CD31) in skin.

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In mice with scald wounds, immunofluorescence showed an enhanced Ki67 signal after GHK‑Cu-liposome treatment.

In plain wordsIn mice with burns, GHK‑Cu-liposomes increased a marker of cell multiplication (Ki67) in skin.

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In mice with scald wounds, wound healing time was shortened to 14 days post injury with GHK‑Cu-liposomes.

In plain wordsIn mice with burns, wounds healed in 14 days after injury with GHK‑Cu-liposomes.

Measurements

Wound healing time

14 days

post injury

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In human umbilical vein endothelial cells, GHK‑Cu-liposomes promoted proliferation, with a 33.1% increased rate.

In plain wordsIn cells, GHK‑Cu-liposomes made blood vessel lining cells multiply faster.

Measurements

Increase in proliferation rate

33.1%

HUVECs, GHK-Cu-liposomes

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In HUVECs, GHK‑Cu-liposomes increased the number of cells at the G1 stage.

In plain wordsIn cells, GHK‑Cu-liposomes increased the number of cells in the G1 stage of the cell cycle.

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In HUVECs, GHK‑Cu-liposomes decreased the number of cells at the G2 stage.

In plain wordsIn cells, GHK‑Cu-liposomes decreased the number of cells in the G2 stage of the cell cycle.

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In HUVECs, GHK‑Cu-liposomes enhanced expression of vascular endothelial growth factor.

In plain wordsIn cells, GHK‑Cu-liposomes raised levels of vascular endothelial growth factor.

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In HUVECs, GHK‑Cu-liposomes enhanced expression of fibroblast growth factor-2.

In plain wordsIn cells, GHK‑Cu-liposomes raised levels of fibroblast growth factor-2.

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In HUVECs, GHK‑Cu-liposomes enhanced expression of the cell cycle-related protein CDK4.

In plain wordsIn cells, GHK‑Cu-liposomes raised levels of the cell cycle protein CDK4.

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In HUVECs, GHK‑Cu-liposomes enhanced expression of the cell cycle-related protein CyclinD1.

In plain wordsIn cells, GHK‑Cu-liposomes raised levels of the cell cycle protein CyclinD1.

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